3-Hydroxyphthalic anhydride
- CAS No.
- 37418-88-5
- Chemical Name:
- 3-Hydroxyphthalic anhydride
- Synonyms
- 4-HYDROXY-ISOBENZOFURAN-1,3-DIONE;Nsc 80858;Brn 0135783;3-HydroxyphthaL;3-hydroxy-phthalicanhydrid;3-hydroxyphtalic anhydride;3-HYDROXYPHTHALIC ANHYDRIDE;Phthalic anhydride, 3-hydroxy-;4-hydroxy-3-isobenzofurandione;3-HYDROXYPHTHALIC ACID ANHYDRIDE
- CBNumber:
- CB3253702
- Molecular Formula:
- C8H4O4
- Molecular Weight:
- 164.12
- MDL Number:
- MFCD00011557
- MOL File:
- 37418-88-5.mol
- MSDS File:
- SDS
| Melting point | 199-202 °C (lit.) |
|---|---|
| Boiling point | 365.4±25.0 °C(Predicted) |
| Density | 1.624±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Acetonitrile (Slightly), DMSO (Slightly) |
| pka | 6.25±0.20(Predicted) |
| form | Powder |
| color | White to beige |
| BRN | 135783 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H |
| InChIKey | CCTOEAMRIIXGDJ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C(O)=CC=C2)C(=O)O1 |
| CAS DataBase Reference | 37418-88-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | RT7FSX9YBD |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | TI3300000 |
| F | 21 |
| HS Code | 29182900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
| Toxicity | mouse,LD50,intravenous,75mg/kg (75mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#08845, |
3-Hydroxyphthalic anhydride price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 308021 | 3-Hydroxyphthalic anhydride 98% | 37418-88-5 | 1g | $333 | 2026-04-30 | Buy |
| TCI Chemical | H1799 | 4-Hydroxyisobenzofuran-1,3-dione min. 98.0 % | 37418-88-5 | 1G | $76 | 2026-04-30 | Buy |
| TCI Chemical | H1799 | 4-Hydroxyisobenzofuran-1,3-dione min. 98.0 % | 37418-88-5 | 5G | $227 | 2026-04-30 | Buy |
| TRC | TRC-H951270-5G | 3-Hydroxyphthalic Anhydride | 37418-88-5 | 5g | $147 | 2026-06-03 | Buy |
| TRC | TRC-H951270-2.5G | 3-Hydroxyphthalic Anhydride | 37418-88-5 | 2.5g | $82 | 2026-06-03 | Buy |
3-Hydroxyphthalic anhydride Chemical Properties, Uses, Production
Description
3-Hydroxyphthalic anhydride: a valuable raw material for chemical industry and pharmaceutical research.
Phthalic anhydride derivatives have been applied as plasticizers and heat-resistant polymers in the chemical industry. One of its derivatives is the 3-hydroxyphthalic anhydride (3-HPA), which exhibits a hydroxyl group substituent in position 3. 3-Hydroxyphthalic anhydride can be used as raw material for heat-resistant resins such as epoxy resins, polyesters, polyimides, etc., or as raw material for physiologically active substances such as medicines and pesticides. It has been shown that 3-HPA can serve as a raw material to obtain drugs with potential applications, such as anticancer, antimicrobial and in treating diabetes, herpes, and HIV[1].
Chemical Properties
Beige powder
Uses
3-Hydroxyphthalic Anhydride is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 5092, 1955 DOI: 10.1021/ja01624a042
Synthesis, p. 788, 1985 DOI: 10.1055/s-1985-31350
Synthesis
In the presence of triethylamine, the 2-oxo-2, 5-dihydrofuran, and pivaloyl chloride reactions generate 2-valeryl oxo furans. The affixture with 2-valeryl oxo furans and maleic anhydride uses vitriolization, which thereby generates the method of 3-hydroxyl phthalic anhydride.
References
[1] M. López-Ortega. “Standard enthalpies of formation of 3-hydroxyphthalic anhydride.” Revista Mexicana De Fisica (2022).
3-Hydroxyphthalic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong XuanHong Pharmaceutical Technology Co.,Ltd | +86-0531-88801869 15090917080 | 2955128025@qq.com | China | 294 | 55 |
| Chongqing TianyiHenghua Technology Co., Ltd. | 15086758486; 15086758486 | chemtyhh@163.com | China | 93 | 58 |
| Wuhan kemike Biomedical Technology Co., Ltd | 027-87747081 18186681184 | 1344475572@qq.com | China | 6944 | 58 |
| Guangdong Baike Reagent Co., Ltd. | 13532366769 13686183698 | 1003878212@qq.com | China | 2951 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
View Latest Price from 3-Hydroxyphthalic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | 3-hydroxy-phthalicanhydrid
37418-88-5
|
$29.00 | 99.53% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 3-HYDROXYPHTHALIC ANHYDRIDE
37418-88-5
|
$10.00 | 1KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-07 | 3-Hydroxyphthalic anhydride
37418-88-5
|
0.98 | 2 tons | Suzhou Nordica Biopharma CO.,LTD |
-
- 3-hydroxy-phthalicanhydrid
37418-88-5
- $29.00
- 99.53%
- TargetMol Chemicals Inc.
-
- 3-HYDROXYPHTHALIC ANHYDRIDE
37418-88-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Hydroxyphthalic anhydride
37418-88-5
- 0.98
- Suzhou Nordica Biopharma CO.,LTD
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