ChemicalBook >> CAS DataBase List >>2-Amino-5-methyl-3-thiophenecarbonitrile
2-Amino-5-methyl-3-thiophenecarbonitrile
- CAS No.
- 138564-58-6
- Chemical Name:
- 2-Amino-5-methyl-3-thiophenecarbonitrile
- Synonyms
- 2-AMINO-5-METHYLTHIOPHENE-3-CARBONITRILE;2-Amino-5-m;AKOS MSC-0403;TIMTEC-BB SBB000075;2-Amino-5-methyl-3-t;Olanzapine Impurity 7;Olanzapine Impurity 1;Olanzapine Impurity 13;Olanzapine impurity SA;Olanzapine impurity BNB
- CBNumber:
- CB3254936
- Molecular Formula:
- C6H6N2S
- Molecular Weight:
- 138.19
- MDL Number:
- MFCD01626055
- MOL File:
- 138564-58-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-16 07:06:08
| Melting point | 101-103°C |
|---|---|
| Boiling point | 318.5±42.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 0.16±0.10(Predicted) |
| color | Light yellow to Brown |
| InChI | InChI=1S/C6H6N2S/c1-4-2-5(3-7)6(8)9-4/h2H,8H2,1H3 |
| InChIKey | YGXADLPRHBRTPG-UHFFFAOYSA-N |
| SMILES | C1(N)SC(C)=CC=1C#N |
| CAS DataBase Reference | 138564-58-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-22 | |||||||||
| Safety Statements | 22-36/37/39 | |||||||||
| RIDADR | 3276 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2-Amino-5-methyl-3-thiophenecarbonitrile price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2351 | 2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC) | 138564-58-6 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | A2351 | 2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC) | 138564-58-6 | 25g | $91 | 2026-04-30 | Buy |
| Usbiological | 259370 | 2-Amino-5-methyl-3-thiophenecarbonitrile | 138564-58-6 | 1g | $446 | 2026-06-03 | Buy |
| Usbiological | 259370 | 2-Amino-5-methyl-3-thiophenecarbonitrile | 138564-58-6 | 2g | $679 | 2026-06-03 | Buy |
| Usbiological | 259370 | 2-Amino-5-methyl-3-thiophenecarbonitrile | 138564-58-6 | 5g | $1044 | 2026-06-03 | Buy |
2-Amino-5-methyl-3-thiophenecarbonitrile Chemical Properties, Uses, Production
Uses
An Impurity generated in the preparation of Olanzapine (O253750).
Synthesis
123-38-6
109-77-3
138564-58-6
General procedure for the synthesis of 2-amino-3-cyano-5-methylthiophene from propionaldehyde and malononitrile: 0.070 g of 4-propylcyclohexanone (0.5 mmol), 0.030 g of malononitrile (0.5 mmol), 0.019 g of powdered sulphur (0.6 mmol), and 0.1 cm3 of NaOH (4 mol/dm3 aqueous solution) in a 1 cm3 choline chloride The mixture/urea was stirred at 60°C for 2-3 hours. The progress of the reaction was monitored by TLC and when the reaction was complete, 5 cm3 of water was added. The solid product was separated by filtration and recrystallized with ethanol if necessary to obtain the pure target compound.
References
[1] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 711 - 716
[2] Research on Chemical Intermediates, 2018, vol. 44, # 3, p. 2195 - 2213
[3] Patent: WO2008/50341, 2008, A2. Location in patent: Page/Page column 32; 33
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 1953 - 1956
[5] Journal of Pharmaceutical Sciences, 2001, vol. 90, # 3, p. 371 - 388
2-Amino-5-methyl-3-thiophenecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 391)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Taizhou Changyuan Chemical Technology Co., Ltd. | 15005869072 | tzcyhxkj@163.com | China | 527 | 58 |
| Jiangxi Fanlai Biomedical Technology Co., Ltd. | 17080805366 | 17080805366@126.com | China | 42 | 58 |
| Henan Aosman Biotechnology Co., LTD | 13761588971 17719817155 | 2366079749@qq.com | China | 3007 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 2-Amino-5-methyl-3-thiophenecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-07-15 | 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
|
$29.00 | 99.33% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
|
$29.00 | 99.33% | 10g | TargetMol Chemicals Inc. |
-
- 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
- $29.00
- 99.33%
- TargetMol Chemicals Inc.
-
- 2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
- $29.00
- 99.33%
- TargetMol Chemicals Inc.
138564-58-6 (2-Amino-5-methyl-3-thiophenecarbonitrile) Related Search:
IMp. A (EP): 5-Methyl-2-[(2-nitrophenyl)-aMino]thiophene-3-carbonitrile
4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride
Olanzapine Impurity(ADP-2b)
Olanzapine ThioacetoxyMethylidene IMpurity
Discontinued
5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
Olanzapine dimer
Olanzapine Impurity K
Olanzapine Benzoate
Olanzapine Impurity(ADP-2c)
2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile
1of4
2-Amino-5-Methyl-3-Nitrothiophene
2-Amino-5-methylthiopene-3-carbonitrile
3-Thiophenecarbonitrile, 2-amino-5-methyl-
2-Amino-5-methyl-3-t
2-Amino-3-cyano-5-methyl
3-Thiophenecarbonitrile,2-amino-5-methyl-(9CI)
TIMTEC-BB SBB000075
2-AMINO-5-METHYL-3-CYANOTHIOPHENE
2-AMINO-5-METHYL-3-THIOPHENECARBONITRILE
2-AMINO-5-METHYLTHIOPEHNE-3-CARBONITRILE
2-AMINO-3-CYANO-5-METHYLTHIOPHENE
Olanzapine Impurity 7
AKOS MSC-0403
Olanzapine Impurity 1
2-Amino-5-m
Olanzapine Impurity 13
2-Amino-5-methyl-3-thiophenecarbonitrile >
Olanzapine impurity BNB
Olanzapine impurity SA
2-Amino-5-methyl-3-thiophenecarbonitrile ISO 9001：2015 REACH
Olanzapine ImpurityQ: What is
Olanzapine Impurity Q: What is the CAS Number of
Olanzapine Impurity Q: What is the storage condition of
Olanzapine Impurity Q: What are the applications of
Olanzapine Impurity
Olanzapine intermediates
2-Amino -5methythiopene-3-carbonitrile
138564-58-6
2‐Amino‐5‐methylthiophene‐3‐
carbonitrile?(DN1)
2-Amino-5-methyl-3-thiophenecarbonitrile, 10 mM in DMSO
2-AMINO-5-METHYLTHIOPHENE-3-CARBONITRILE
138564-58-6
138654-58-6
1632539-06-1
C6H6N2S
Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Olanzapine
Heterocycle-oher series
Thiophene&Benzothiophene
Amines
(intermediate of olanzapine)
NITRILE
138564-58-6
OLED
