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2-Amino-5-methyl-3-thiophenecarbonitrile

2-Amino-5-methyl-3-thiophenecarbonitrile structure

CAS No.: 138564-58-6

Chemical Name:: 2-Amino-5-methyl-3-thiophenecarbonitrile

Synonyms: 2-Amino-5-m;AKOS MSC-0403;TIMTEC-BB SBB000075;2-Amino-5-methyl-3-t;Olanzapine Impurity 7;Olanzapine Impurity 1;Olanzapine Impurity 13;Olanzapine impurity SA;Olanzapine impurity BNB;2-Amino-3-cyano-5-methyl

CBNumber:: CB3254936

Molecular Formula:: C6H6N2S

Molecular Weight:: 138.19

MDL Number:: MFCD01626055

MOL File:: 138564-58-6.mol

MSDS File:: SDS

Last updated:2025-09-20 20:09:13

Product description	Number	Pack Size	Price
2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC)	A2351	5g	$30
2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC)	A2351	25g	$98
2-Amino-5-methyl-3-thiophenecarbonitrile	A618260	1g	$110
2-Amino-5-methyl-3-thiophenecarbonitrile	259370	1g	$446
2-Amino-5-methyl-3-thiophenecarbonitrile	49520	2.5g	$640
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2-Amino-5-methyl-3-thiophenecarbonitrile Properties

Melting point	101-103°C
Boiling point	318.5±42.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	soluble in Methanol
form	powder to crystal
pka	0.16±0.10(Predicted)
color	Light yellow to Brown
InChI	InChI=1S/C6H6N2S/c1-4-2-5(3-7)6(8)9-4/h2H,8H2,1H3
InChIKey	YGXADLPRHBRTPG-UHFFFAOYSA-N
SMILES	C1(N)SC(C)=CC=1C#N
CAS DataBase Reference	138564-58-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319

Precautionary statements

P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501

Hazard Codes

Xi,Xn

Risk Statements

20/21/22-22

Safety Statements

22-36/37/39

RIDADR

3276

HazardClass

IRRITANT

HS Code

29349990

NFPA 704

	1
2		0

2-Amino-5-methyl-3-thiophenecarbonitrile price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2351	2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC)	138564-58-6	5g	$30	2025-07-31	Buy
TCI Chemical	A2351	2-Amino-5-methyl-3-thiophenecarbonitrile >98.0%(GC)	138564-58-6	25g	$98	2025-07-31	Buy
TRC	A618260	2-Amino-5-methyl-3-thiophenecarbonitrile	138564-58-6	1g	$110	2021-12-16	Buy
Usbiological	259370	2-Amino-5-methyl-3-thiophenecarbonitrile	138564-58-6	1g	$446	2021-12-16	Buy
Medical Isotopes, Inc.	49520	2-Amino-5-methyl-3-thiophenecarbonitrile	138564-58-6	2.5g	$640	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2351	5g	$30	Buy
A2351	25g	$98	Buy
A618260	1g	$110	Buy
259370	1g	$446	Buy
49520	2.5g	$640	Buy

2-Amino-5-methyl-3-thiophenecarbonitrile Chemical Properties,Uses,Production

Uses

An Impurity generated in the preparation of Olanzapine (O253750).

Synthesis

123-38-6

109-77-3

2-Amino-5-methyl-3-thiophenecarbonitrile

138564-58-6

General procedure for the synthesis of 2-amino-3-cyano-5-methylthiophene from propionaldehyde and malononitrile: 0.070 g of 4-propylcyclohexanone (0.5 mmol), 0.030 g of malononitrile (0.5 mmol), 0.019 g of powdered sulphur (0.6 mmol), and 0.1 cm3 of NaOH (4 mol/dm3 aqueous solution) in a 1 cm3 choline chloride The mixture/urea was stirred at 60°C for 2-3 hours. The progress of the reaction was monitored by TLC and when the reaction was complete, 5 cm3 of water was added. The solid product was separated by filtration and recrystallized with ethanol if necessary to obtain the pure target compound.

References

[1] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 711 - 716
[2] Research on Chemical Intermediates, 2018, vol. 44, # 3, p. 2195 - 2213
[3] Patent: WO2008/50341, 2008, A2. Location in patent: Page/Page column 32; 33
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 1953 - 1956
[5] Journal of Pharmaceutical Sciences, 2001, vol. 90, # 3, p. 371 - 388

2-Amino-5-methyl-3-thiophenecarbonitrile Preparation Products And Raw materials

Raw materials

Propionaldehyde Malononitrile Sulfur Urea Choline chloride

Preparation Products

5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile 2-AMINO-5-METHYL-3-THIOPHENECARBOXAMIDE

2-Amino-5-methyl-3-thiophenecarbonitrile Suppliers

Global( 375)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Richest Group Ltd	18017061086	oled@richest-group.com	CHINA	5600	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Richest Group Ltd	58

View Lastest Price from 2-Amino-5-methyl-3-thiophenecarbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-19	2-Amino-5-methyl-3-thiophenecarbonitrile 138564-58-6	US $29.00 / mg		99.33%	10g	TargetMol Chemicals Inc.
2025-09-19	2-Amino-5-methyl-3-thiophenecarbonitrile 138564-58-6	US $29.00 / mg		99.33%	10g	TargetMol Chemicals Inc.
2024-02-19	2-Amino-5-methylthiophene-3-carbonitrile 138564-58-6	US $790.00 / g	1g	97	500 Kg	R&D Scientific Inc.

2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
US $29.00 / mg
99.33%
TargetMol Chemicals Inc.

2-Amino-5-methyl-3-thiophenecarbonitrile
138564-58-6
US $29.00 / mg
99.33%
TargetMol Chemicals Inc.

2-Amino-5-methylthiophene-3-carbonitrile
138564-58-6
US $790.00 / g
97
R&D Scientific Inc.

2-Amino-5-methyl-3-thiophenecarbonitrile Spectrum

2-Amino-5-methyl-3-thiophenecarbonitrile(138564-58-6)¹HNMR

138564-58-6(2-Amino-5-methyl-3-thiophenecarbonitrile)Related Search:

Olanzapine Impurity K Olanzapine dimer 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Olanzapine ThioacetoxyMethylidene IMpurity Discontinued Olanzapine Impurity(ADP-2b)

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride IMp. A (EP): 5-Methyl-2-[(2-nitrophenyl)-aMino]thiophene-3-carbonitrile HydroxyMethylidene thione Olanzapine Benzoate Olanzapine Impurity(ADP-2c)

1-Fluoro-2-nitrobenzene 2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile Olanzapine iMpurity (1-(5'-Methylthiophen-2'-yl)-1,3-dihydrobenzoiMidazol-2-one) 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE

2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE Methyl 5-amino-4-cyano-3-methylthiophene-2-carboxylate 6-(DIMETHOXYMETHYL)-2-MERCAPTONICOTINONITRILE

1of4

2-Amino-5-Methyl-3-Nitrothiophene 2-Amino-5-methylthiopene-3-carbonitrile 3-Thiophenecarbonitrile, 2-amino-5-methyl- 2-Amino-5-methyl-3-t 2-Amino-3-cyano-5-methyl 3-Thiophenecarbonitrile,2-amino-5-methyl-(9CI) TIMTEC-BB SBB000075 2-AMINO-5-METHYL-3-CYANOTHIOPHENE 2-AMINO-5-METHYL-3-THIOPHENECARBONITRILE 2-AMINO-5-METHYLTHIOPEHNE-3-CARBONITRILE 2-AMINO-5-METHYLTHIOPHENE-3-CARBONITRILE 2-AMINO-3-CYANO-5-METHYLTHIOPHENE Olanzapine Impurity 7 AKOS MSC-0403 Olanzapine Impurity 1 2-Amino-5-m Olanzapine Impurity 13 2-Amino-5-methyl-3-thiophenecarbonitrile > Olanzapine impurity BNB Olanzapine impurity SA 2-Amino-5-methyl-3-thiophenecarbonitrile ISO 9001：2015 REACH Olanzapine ImpurityQ: What is Olanzapine Impurity Q: What is the CAS Number of Olanzapine Impurity Q: What is the storage condition of Olanzapine Impurity Q: What are the applications of Olanzapine Impurity Olanzapine intermediates 2-Amino -5methythiopene-3-carbonitrile 138564-58-6 2‐Amino‐5‐methylthiophene‐3‐ carbonitrile?(DN1) 2-Amino-5-methyl-3-thiophenecarbonitrile, 10 mM in DMSO 138564-58-6 138654-58-6 1632539-06-1 C6H6N2S Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Olanzapine Heterocycle-oher series Thiophene&Benzothiophene Amines (intermediate of olanzapine) NITRILE 138564-58-6 OLED