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N-NITROSODIETHANOLAMINE

N-NITROSODIETHANOLAMINE Structure
N-NITROSODIETHANOLAMINE structure
CAS No.
1116-54-7
Chemical Name:
N-NITROSODIETHANOLAMINE
Synonyms
ndela;nitrosodiethanolamine;Nitrosobis(2-hydroxyethyl)amine;N,N-bis(2-hydroxyethyl)nitrous amide;nci-c55583;rcrawastenumberu173;diaethanolnitrosamin;DIETHANOLNITROSAMINE;Trolamine Impurity C;nitrosoiminodiethanol
CBNumber:
CB8401443
Molecular Formula:
C4H10N2O3
Molecular Weight:
134.13
MDL Number:
MFCD00015522
MOL File:
1116-54-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:57:12
Product description Number Pack Size Price
N-Nitrosodiethanolamine N7632 500mg $128
N-Nitrosodiethanolamine N7632 1g $238
N-Nitrosodiethanolamine analytical standard 68137 100 mg $163
N-Nitrosodiethanolamine >97.0%(GC) N0438 5g $288
N-Nitrosodiethanolamine >97.0%(GC) N0438 25g $716
More product size
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N-NITROSODIETHANOLAMINE Properties

Melting point 200 °C (decomp)
Boiling point bp0.01 125°
Density 1,26 g/cm3
refractive index nD20 1.4849
Flash point 11℃
storage temp. 2-8°C
Water Solubility Completely miscible in water
solubility DMSO (Soluble), Ethyl Acetate (Sparingly), Methanol (Soluble), Water (Sparingly)
form clear liquid to slightly cloudy liquid
pka 13.76±0.10(Predicted)
color Light yellow to Brown
Merck 14,6634
BRN 1762620
Henry's Law Constant 2.0×106 mol/(m3Pa) at 25℃, HSDB (2015)
CAS DataBase Reference 1116-54-7(CAS DataBase Reference)
FDA UNII 30YI1289VY
Proposition 65 List n-Nitrosodiethanolamine
IARC 2B (Vol. 17, Sup 7, 77) 2000
EPA Substance Registry System N-Nitrosodiethanolamine (1116-54-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H350
Precautionary statements  P201-P210-P305+P351+P338-P308+P313
Hazard Codes  T,F
Risk Statements  45-11
Safety Statements  53-45-16
RIDADR  UN 1993 3/PG 2
WGK Germany  1
RTECS  KL9550000
TSCA  TSCA listed
HS Code  2922.19.9690
HazardClass  3.1
PackingGroup  II
Hazardous Substances Data 1116-54-7(Hazardous Substances Data)
Toxicity LD50 orl-rat: 7500 mg/kg GISAAA 40(1),81,75
NFPA 704
3
2 0

N-NITROSODIETHANOLAMINE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N7632 N-Nitrosodiethanolamine 1116-54-7 500mg $128 2026-04-30 Buy
Sigma-Aldrich N7632 N-Nitrosodiethanolamine 1116-54-7 1g $238 2026-04-30 Buy
Sigma-Aldrich 68137 N-Nitrosodiethanolamine analytical standard 1116-54-7 100 mg $163 2026-04-30 Buy
TCI Chemical N0438 N-Nitrosodiethanolamine >97.0%(GC) 1116-54-7 5g $288 2026-04-30 Buy
TCI Chemical N0438 N-Nitrosodiethanolamine >97.0%(GC) 1116-54-7 25g $716 2026-04-30 Buy
Product number Packaging Price Buy
N7632 500mg $128 Buy
N7632 1g $238 Buy
68137 100 mg $163 Buy
N0438 5g $288 Buy
N0438 25g $716 Buy

N-NITROSODIETHANOLAMINE Chemical Properties,Uses,Production

Chemical Properties

Reddish Yellow Oil

Uses

A potent liver carcinogen in several species of animals, is one of the most widespread N-nitroso compounds in the human environment.

Definition

ChEBI: N-Nitrosodiethanolamine is a nitroso compound.

General Description

Yellow to dark brown very viscous liquid with no distinct odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

N-NITROSODIETHANOLAMINE can react with alkoxides. N-NITROSODIETHANOLAMINE reacts with sulfuric acid at temperatures above 311° F.

Health Hazard

ACUTE/CHRONIC HAZARDS: N-NITROSODIETHANOLAMINE may be harmful by eye or skin contact, inhalation or ingestion. It is an irritant and, when heated to decomposition, it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for N-NITROSODIETHANOLAMINE are not available; however, N-NITROSODIETHANOLAMINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data.Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and ALCOHOLS.

Carcinogenicity

N-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

Purify NDELA by dissolving the amine (0.5g) in 1-propanol (10mL) and 5g of anhydrous Na2SO4 added with stirring. After standing for 1-2hours, it is filtered and passed through a chromatographic column packed with 10mL of AG 50W x 8 (H+form 50-100mesh, a strongly acidic cation exchanger). The eluent and washings (50 mL EtOH) are combined and evaporated to dryness at 35o. It has also been extracted with EtOH from the nitrosation mixture of ethanolamine, filtered and distilled under high vacuum. [Fukuda et al. Anal Chem 53 2000 1981, Jones & Wilson J Chem Soc 550, 1949, Beilstein 1 III 721, see Spiegelhalder et al. N-Nitroso Compounds: Occurrence Biological Effects and Relevance in Human Cancer (eds. O’Neill et al. IARC Scientific Publications No 57; IARC Lyon p943 1984.] Possible

Toxics Screening Level

The Initial Risk Screening Level (IRSL) for n-nitrosodiethanolamine is 0.0012 μg/m3 based on an annual averaging time.

N-NITROSODIETHANOLAMINE synthesis

111-42-2
1116-54-7
Synthesis of N-NITROSODIETHANOLAMINE from Diethanolamine

N-NITROSODIETHANOLAMINE Preparation Products And Raw materials

Raw materials

Ethanol, 2-[(3,7-dimethyloctyl)nitrosoamino]- Ethanol, 2,2'-[(3,7-dimethyl-2,6-octadienyl)imino]bis-, (E)- (9CI) (E)-2-((3,7-Dimethyl-2,6-octadienyl)nitrosoamino)ethanol S-nitroso-N-acetylcysteine S-NITROSOGLUTATHIONE
Triethanolamine Diethanolamine

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Preparation Products

Formaldehyde

N-NITROSODIETHANOLAMINE Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-17392712779 1097@dideu.com China 3989 58
Chemsigma International Co., Ltd. 		+86-2558742998 +86-19951791336 info@chemsigma.com China 1824 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49859 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501 product@acmec-e.com China 33301 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		+86-18603013401 jack.lin@sincopharmachem.com China 9999 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32288 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44849 61
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Chemsigma International Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
Sinco Pharmachem (ShenZhen) R&D Co., Ltd. 		58
Mainchem Co., Ltd. 55
Energy Chemical 61

View Lastest Price from N-NITROSODIETHANOLAMINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-NITROSODIETHANOLAMINE pictures 2025-12-24 N-NITROSODIETHANOLAMINE
1116-54-7
 1KG 98.0% 10 Shaanxi Dideu Medichem Co. Ltd

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2,2’-nitrosiminodi-ethano bis-(2-hydroxy-ethyl)-nitroso-amine bis(beta-hydroxyaethyl)nitrosamin bis(beta-hydroxyethyl)nitrosamine bis-2-hydroxy-ethyl-nitroso-amine di-(2-hydroxyethyl)-nitrosamine diaethanolnitrosamin diethanolnitrosoamine n,n-diethanolnitrosamine nci-c55583 nitrosoiminodiethanol n-nitrosoaminodiethanol n-nitrosobis(2-hydroxyethyl)amine n-Nitroso-bis(2-hydroxymethyl)-amine n-nitrosodiaethanolamin n-nitrosoiminodi-ethano 2,2'-dihydroxy-N-nitrosodiethylamine 2,2'-nitrosiminodiethanol N-Nitrosodiethanolamine? N-nitrosoiminodiethanol Ethanol, 2,2-(nitrosoimino)bis- N-DIETHANOLNITROSAMINE ETHANOL,N-NITROSOIMINODI- bis(beta-hydroxyaethyl)nitrosamin (german) diaethanolnitrosamin (german) rcrawastenumberu173 N-NITROSODIETHANOLAMINE DIETHANOLNITROSAMINE 2,2'-(Nitrosoimino)diethanol Bis(2-hydroxyethyl)nitrosamine N-Nitrosodiethanolamine 2,2’-(nitrosoimino)bis-ethano 2,2’-dihydroxy-n-nitroso-diethylamin 2,2’-iminodi-n-nitrosoethanol 2,2’-(nitrosoimino)bisethanol 2,2’-(nitrosoimino)bis-Ethanol N-Nitrosodiethanolamine> N-Nitroso-diethanolamine Solution in Methanol, 1000μg/mL N-Nitrosoamindiethanol 2-[(2-hydroxyethyl)(nitroso)amino]ethan-1-ol Trolamine Impurity C Trolamine EP Impurity C 2,2′-(nitrosoimino)diethanol (N-nitrosodiethanolamine) N-nitroso-diethanolamine NDELA 3,7 2,2'-(Nitrosoimino)diethanol (N-Nitrosodiethanolamine) N-Nitroso Trazodone Impurity 12 N-Nitroso-diethanolamine 100 μg/mL in Methanol N-Nitrosodiethanolamine(NDELA) Morinidazole Impurity 34 N,N-bis(2-hydroxyethyl)nitrous amide ndela nitrosodiethanolamine Nitrosobis(2-hydroxyethyl)amine 1116-54-7 HOCD2CD2NNO Amines Nitric Oxide Reagents Nitrosamine pharmacetical