1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- CAS No.
- 97075-46-2
- Chemical Name:
- 1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- Synonyms
- N,N'-dibenzhydrylethane-1,2-diamine;AMN082 dihydrochloride, mGlu7 agonist;N1,N2-Dibenzhydrylethane-1,2-diamine dihydrochloride;1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride
- CBNumber:
- CB32609376
- Molecular Formula:
- C28H29ClN2
- Molecular Weight:
- 429
- MDL Number:
- MFCD08702723
- MOL File:
- 97075-46-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | <46.55mg/ml in DMSO;insoluble in H2O |
| form | solid |
| color | White |
| InChI | 1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H |
| InChIKey | YRQCDCNQANSUPB-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P273-P391-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04745 | AMN082 Dihydrochloride - CAS 97075-46-2 - Calbiochem | 97075-46-2 | 10MG | $115 | 2022-05-15 | Buy |
| Cayman Chemical | 28779 | AMN082 ≥98% | 97075-46-2 | 5mg | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 28779 | AMN082 ≥98% | 97075-46-2 | 10mg | $141 | 2026-04-30 | Buy |
| Cayman Chemical | 28779 | AMN082 ≥98% | 97075-46-2 | 25mg | $313 | 2026-04-30 | Buy |
| Usbiological | 254625 | AMN 082 dihydrochloride Asreported | 97075-46-2 | 10mg | $366 | 2026-06-03 | Buy |
1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride Chemical Properties, Uses, Production
Description
AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson''s disease induced by 6-hydroxy dopamine (6-OHDA; ).
Uses
AMN082 dihydrochloride is a selective agonist at mGluR-7.
Definition
ChEBI: AMN082 dihydrochloride is a hydrochloride obtained by combining N,N'-bis(diphenylmethyl)ethane-1,2-diamine with two molar equivalent of hydrochloric acid. It has a role as a metabotropic glutamate receptor agonist, a geroprotector and a neuroprotective agent. It contains a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).
in vivo
treatment with amn082 was shown to penetrate into the brain and hence it modulated the level of stress hormones (acth and cortisol) in wild type animal. but these effects were not found in the mglur7 ko mouse [2].
storage
+4°C (desiccate)
References
[1]. pelkey ka, yuan x, lavezzari g, et al. mglur7 undergoes rapid internalization in response to activation by the allosteric agonist amn082. neuropharmacology, 2007, 52(1): 108-117.
[2]. gasparini f, spooren w. allosteric modulators for mglu receptors. current neuropharmacology, 2007, 5(3): 187-194.
1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-EthanediaMine, N,N'-bis(diphenylMethyl)-, dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9783 | 55 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9384 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
