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8-M-PDOT

8-M-PDOT Structure
8-M-PDOT structure
CAS No.
134865-70-6
Chemical Name:
8-M-PDOT
Synonyms
AH 002;8-M-PDOT;8 M PDOT,8MPDOT;8-M-PDOT, 10 mM in DMSO;8-METHOXY-2-PROPIONAMIDOTETRALIN;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-
CBNumber:
CB9487996
Molecular Formula:
C14H19NO2
Molecular Weight:
233.31
MDL Number:
MFCD00901636
MOL File:
134865-70-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-11 16:31:51
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8-M-PDOT Properties

Boiling point 447.8±45.0 °C(Predicted)
Density 1.09±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 50 mM in ethanol and to 100 mM in DMSO
form Powder
pka 15.87±0.20(Predicted)
color White to off-white

8-M-PDOT price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29521 8-M-PDOT ≥98% 134865-70-6 5mg $91 2026-04-30 Buy
Cayman Chemical 29521 8-M-PDOT ≥98% 134865-70-6 10mg $152 2026-04-30 Buy
Cayman Chemical 29521 8-M-PDOT ≥98% 134865-70-6 25mg $357 2026-04-30 Buy
Cayman Chemical 29521 8-M-PDOT ≥98% 134865-70-6 50mg $667 2026-04-30 Buy
Biosynth JFA86570 AH 002 134865-70-6 25mg $853.75 2026-06-04 Buy
Product number Packaging Price Buy
29521 5mg $91 Buy
29521 10mg $152 Buy
29521 25mg $357 Buy
29521 50mg $667 Buy
JFA86570 25mg $853.75 Buy

8-M-PDOT Chemical Properties, Uses, Production

Description

8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.

Uses

AH 002 is a selective melatonin receptor agonist.

Biological Activity

Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.

in vivo

8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].

Animal Model:Male Wistar rats (280-320 g) with Rotenone[2]
Dosage:10 μg/μL
Administration:Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result:Increased percentage of time spent in the open arms and in the number of open arms entries.

IC 50

MT2

References

[1] CHRISTOPHER BROWNING. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors[J]. British Journal of Pharmacology, 2009, 129 5: 877-886. DOI: 10.1038/sj.bjp.0703130
[2] ANA CAROLINA D. NOSEDA. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects[J]. Sleep Science, 2016, 9 1: Pages 47-54. DOI: 10.1016/j.slsci.2015.10.002

8-M-PDOT Preparation Products And Raw materials

Raw materials

Preparation Products

8-M-PDOT Suppliers

Global Suppliers ( 40)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25030 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2377 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Shanghai Universal Biotech Co.,Ltd 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
TargetMol Chemicals Inc. 58

View Latest Price from 8-M-PDOT manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
8-M-PDOT pictures 2026-05-11 8-M-PDOT
134865-70-6
 $30.00-118.00 99.54% 10g TargetMol Chemicals Inc.
8-M-PDOT pictures 2026-05-11 8-M-PDOT
134865-70-6
 $30.00-118.00 99.54% 10g TargetMol Chemicals Inc.
8-M-PDOT pictures 2025-07-18 8-M-PDOT
134865-70-6
 $30.00-118.00 99.54% 10g TargetMol Chemicals Inc.
  • 8-M-PDOT pictures
  • 8-M-PDOT
    134865-70-6
  • $30.00-118.00
  • 99.54%
  • TargetMol Chemicals Inc.
  • 8-M-PDOT pictures
  • 8-M-PDOT
    134865-70-6
  • $30.00-118.00
  • 99.54%
  • TargetMol Chemicals Inc.
  • 8-M-PDOT pictures
  • 8-M-PDOT
    134865-70-6
  • $30.00-118.00
  • 99.54%
  • TargetMol Chemicals Inc.

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8-METHOXY-2-PROPIONAMIDOTETRALIN 8-M-PDOT AH 002 8 M PDOT,8MPDOT Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)- 8-M-PDOT, 10 mM in DMSO 134865-70-6