PHA 408
- CAS No.
- 503555-55-3
- Chemical Name:
- PHA 408
- Synonyms
- 8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide;PHA 408;PHA-408【PZ0266】;PHA408 (PHA-408);PHA-408 >=98% (HPLC);8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide;1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
- CBNumber:
- CB32628254
- Molecular Formula:
- C29H27ClFN7O2
- Molecular Weight:
- 560.02
- MDL Number:
- MFCD17166977
- MOL File:
- 503555-55-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PHA-408 ≥98% (HPLC) | PZ0266 | 5mg | $115 |
| PHA-408 ≥98% (HPLC) | PZ0266 | 25mg | $462 |
| PHA-408 ≥98% | 41279 | 1mg | $31 |
| PHA-408 ≥98% | 41279 | 5mg | $124 |
| PHA-408 ≥98% | 41279 | 10mg | $231 |
| Boiling point | 727.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 5mg/mL, clear (warmed) |
| form | powder |
| pka | 10.18±0.20(Predicted) |
| color | white to beige |
| InChIKey | ZLEZHGHFWIHCGU-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)[n]2nc(c3c2c4c(ccc(c4)NC(=O)c5c(cnc(c5)N6CCN(CC6)C)Cl)CC3)C(=O)N |
| FDA UNII | 8K8XT2KBG3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
| target organs | Respiratory system |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
PHA 408 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0266 | PHA-408 ≥98% (HPLC) | 503555-55-3 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0266 | PHA-408 ≥98% (HPLC) | 503555-55-3 | 25mg | $462 | 2024-03-01 | Buy |
| Cayman Chemical | 41279 | PHA-408 ≥98% | 503555-55-3 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 41279 | PHA-408 ≥98% | 503555-55-3 | 5mg | $124 | 2026-04-30 | Buy |
| Cayman Chemical | 41279 | PHA-408 ≥98% | 503555-55-3 | 10mg | $231 | 2026-04-30 | Buy |
PHA 408 Chemical Properties,Uses,Production
Uses
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1].
Biological Activity
PHA-408 is a potent, selective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight binding, ATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular events, and to reduce inflammation in animal models of arthritis.
IC 50
IKK-2
References
[1] Rajendrasozhan S, et al. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther. 2010 Jun;23(3):172-81. DOI:10.1016/j.pupt.2010.01.002
PHA 408 Preparation Products And Raw materials
Raw materials
Preparation Products
PHA 408 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 3000 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9647 | 58 |
