RI-1
- CAS No.
- 415713-60-9
- Chemical Name:
- RI-1
- Synonyms
- CS-909;RI-1, >=98%;Seebio RI-1;RAD51 inhibitor;RI-1 >=98% (HPLC);RAD51 inhibitor 1;RI-1, 10 mM in DMSO;RAD51 inhibitor RI-1;RI 1, RAD51 inhibitor;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit
- CBNumber:
- CB32628355
- Molecular Formula:
- C14H11Cl3N2O3
- Molecular Weight:
- 361.61
- MDL Number:
- MFCD00814248
- MOL File:
- 415713-60-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 483.0±45.0 °C(Predicted) |
|---|---|
| Density | 1.61 |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | -3.45±0.20(Predicted) |
| form | powder |
| color | yellow to orange |
| biological source | human blood |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChI | 1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2 |
| InChIKey | MWSUIZKGNWELRF-UHFFFAOYSA-N |
| SMILES | ClC1=C(Cl)C=CC(N2C(C(N3CCOCC3)=C(Cl)C2=O)=O)=C1 |
| FDA UNII | S8WG8ZRQ99 |
| UNSPSC Code | 41106514 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
RI-1 price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1274 | RI-1 ≥98% (HPLC) | 415713-60-9 | 5mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1274 | RI-1 ≥98% (HPLC) | 415713-60-9 | 25mg | $433 | 2026-04-30 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 5mg | $77 | 2026-04-30 | Buy |
| Cayman Chemical | 24182 | RI-1 ≥98% | 415713-60-9 | 10mg | $135 | 2026-04-30 | Buy |
RI-1 Chemical Properties, Uses, Production
Description
RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
Uses
RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.
Biochem/physiol Actions
RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.
in vivo
RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice[2].
| Animal Model: | Female BALB/c nude mice (6 weeks) bearing TNBC tumor[2] |
| Dosage: | 50 mg/kg |
| Administration: | I.p. every 3 days for 30 days |
| Result: | Resulted in significant inhibition of tumor growth. Did not cause body weight loss significantly. |
target
RAD51
References
[1] RANJITH ANAND. Rad51-mediated double-strand break repair and mismatch correction of divergent substrates[J]. Nature, 2017, 544 7650: 377-380. DOI:10.1038/nature22046
[2] BRIAN BUDKE. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.[J]. Nucleic Acids Research, 2012, 40 15: 7347-7357. DOI:10.1093/nar/gks353
[3] ANAÏS BALBOUS. A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells.[J]. BMC Cancer, 2016: 604. DOI:10.1186/s12885-016-2647-9
[4] NANCY BERTE. Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.[J]. Molecular Cancer Therapeutics, 2016, 15 11: 2665-2678. DOI:10.1158/1535-7163.mct-16-0176
RI-1 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 |
View Latest Price from RI-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | RI-1
415713-60-9
|
$37.00-105.00 | 99.49% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
415713-60-9
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- RI-1
415713-60-9
- $37.00-105.00
- 99.49%
- TargetMol Chemicals Inc.
-
- 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
415713-60-9
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
