- RI-1
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- $37.00
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2026-07-14
- CAS:415713-60-9
- Purity: 99.49%
- Supply Ability: 10g
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| Product Name: | RI-1 | | Synonyms: | 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;RI-1, >=98%;RAD51 inhibitor RI-1;RAD51 inhibitor 1;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-; 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione;CS-909 | | CAS: | 415713-60-9 | | MF: | C14H11Cl3N2O3 | | MW: | 361.61 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 415713-60-9.mol |  |
| Boiling point | 483.0±45.0 °C(Predicted) | | density | 1.61 | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | -3.45±0.20(Predicted) | | form | powder | | color | yellow to orange | | biological source | human blood | | Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. | | InChI | 1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2 | | InChIKey | MWSUIZKGNWELRF-UHFFFAOYSA-N | | SMILES | ClC1=C(Cl)C=CC(N2C(C(N3CCOCC3)=C(Cl)C2=O)=O)=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Description | RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4. | | Uses | RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells. | | Biochem/physiol Actions | RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells. | | in vivo | RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice[2]. | Animal Model: | Female BALB/c nude mice (6 weeks) bearing TNBC tumor[2] | | Dosage: | 50 mg/kg | | Administration: | I.p. every 3 days for 30 days | | Result: | Resulted in significant inhibition of tumor growth.
Did not cause body weight loss significantly.
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| | target | RAD51 | | References | [1] RANJITH ANAND. Rad51-mediated double-strand break repair and mismatch correction of divergent substrates[J]. Nature, 2017, 544 7650: 377-380. DOI:10.1038/nature22046
[2] BRIAN BUDKE. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.[J]. Nucleic Acids Research, 2012, 40 15: 7347-7357. DOI:10.1093/nar/gks353
[3] ANAÏS BALBOUS. A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells.[J]. BMC Cancer, 2016: 604. DOI:10.1186/s12885-016-2647-9
[4] NANCY BERTE. Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.[J]. Molecular Cancer Therapeutics, 2016, 15 11: 2665-2678. DOI:10.1158/1535-7163.mct-16-0176 |
| | RI-1 Preparation Products And Raw materials |
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