TCPOBOP
- CAS No.
- 76150-91-9
- Chemical Name:
- TCPOBOP
- Synonyms
- TCPOBOP;TCPOBOP, 10 mM in DMSO;3,3',5,5'-TETRACHLORIDE-BPB;TCPOBOP - CAS 76150-91-9 - Calbiochem;inhibit,Bcl-2 Family,TCPOBOP,Inhibitor;1,4-Bis(3,5-dichloro-2-pyridyloxy)benzene;1,4-BIS[2-(3,5-DICHLOROPYRIDYLOXY)]BENZENE;1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene;TCPOBOP, Androstane receptor (mCAR) agonist;3,3',5,5'-TETRACHLORIDE-BISPYRIDYLOXYBENZENE
- CBNumber:
- CB8155924
- Molecular Formula:
- C16H8Cl4N2O2
- Molecular Weight:
- 402.06
- MDL Number:
- MFCD00057368
- MOL File:
- 76150-91-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| TCPOBOP ≥98% (HPLC), solid | T1443 | 5mg | $89 |
| TCPOBOP | 580563 | 25mg | $195 |
| TCPOBOP | T4221 | 50MG | $246 |
| TCPOBOP ≥95% | 14140 | 5mg | $44 |
| TCPOBOP ≥95% | 14140 | 10mg | $78 |
| Boiling point | 444.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.518±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10 mg/mL |
| pka | -0.52±0.10(Predicted) |
| form | solid |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week. |
| InChI | 1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H |
| InChIKey | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| SMILES | Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1 |
| FDA UNII | P4R368GDD7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | UT7145000 |
| Storage Class | 11 - Combustible Solids |
TCPOBOP price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T1443 | TCPOBOP ≥98% (HPLC), solid | 76150-91-9 | 5mg | $89 | 2026-03-19 | Buy |
| Sigma-Aldrich | 580563 | TCPOBOP | 76150-91-9 | 25mg | $195 | 2026-03-19 | Buy |
| TCI Chemical | T4221 | TCPOBOP | 76150-91-9 | 50MG | $246 | 2026-03-19 | Buy |
| Cayman Chemical | 14140 | TCPOBOP ≥95% | 76150-91-9 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 14140 | TCPOBOP ≥95% | 76150-91-9 | 10mg | $78 | 2024-03-01 | Buy |
TCPOBOP Chemical Properties,Uses,Production
Description
TCPOBOP (76150-91-9) is an activator of the mouse constitutive androstane receptor (mCAR) and human Preganane X receptor.1 Tumor promoter of mouse hepatocarcinogenesis.
Uses
TCPOBOP is an agonist for mCAR, inducing cytochrome P450 monooxygenases and multidrug resistance and cenobiotic efflux proteins.
General Description
A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Biochem/physiol Actions
TCPOBOP enhances the nuclear receptor CAR transactivation of cytochrome P450 (CYP), as dose-dependent direct agonist of CAR. The most potent known member of the phenobarbital-like class of CYP-inducing agents.
in vivo
TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].
| Animal Model: | METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] |
| Dosage: | 3 mg/kg |
| Administration: | Oral; 1, 2, 5 days |
| Result: | Increased Liver weight to body weight. |
IC 50
Bcl-2
References
[1] I TZAMELI. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR.[J]. Molecular and Cellular Biology, 2000, 20 9: 2951-2958. DOI:10.1128/mcb.20.9.2951-2958.2000
[2] B A DIWAN. Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine.[J]. Carcinogenesis, 1992, 13 10: 1893-1901. DOI:10.1093/carcin/13.10.1893
TCPOBOP Preparation Products And Raw materials
Raw materials
Preparation Products
TCPOBOP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 26707 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
