2,6-Dichloro-3,5-dimethoxyaniline
- CAS No.
- 872509-56-3
- Chemical Name:
- 2,6-Dichloro-3,5-dimethoxyaniline
- Synonyms
- 157427;oro-3,5-dimethoxyaniL;2,6-Dichloro-3,5-dimethoxyaniline;2,6-Dichloro-3,5-dimethoxybenzenamine;2,6-Dichloro-3,5-dimethoxy-phenylamine;Benzenamine, 2,6-dichloro-3,5-dimethoxy-
- CBNumber:
- CB32651401
- Molecular Formula:
- C8H9Cl2NO2
- Molecular Weight:
- 222.07
- MDL Number:
- MFCD21648506
- MOL File:
- 872509-56-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 320℃ |
|---|---|
| Density | 1.357 |
| Flash point | 147℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | -0.13±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C8H9Cl2NO2/c1-12-4-3-5(13-2)7(10)8(11)6(4)9/h3H,11H2,1-2H3 |
| InChIKey | LCQFHEIDCMPNAN-UHFFFAOYSA-N |
| SMILES | C1(N)=C(Cl)C(OC)=CC(OC)=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2922299090 |
2,6-Dichloro-3,5-dimethoxyaniline price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR71144 | 2,6-Dichloro-3,5-dimethoxyaniline >98% | 872509-56-3 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR71144 | 2,6-Dichloro-3,5-dimethoxyaniline >98% | 872509-56-3 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR71144 | 2,6-Dichloro-3,5-dimethoxyaniline >98% | 872509-56-3 | 5g | $90 | 2026-06-04 | Buy |
| Apolloscientific | OR71144 | 2,6-Dichloro-3,5-dimethoxyaniline >98% | 872509-56-3 | 25g | $430 | 2026-06-04 | Buy |
| Activate Scientific | AS47132 | 2,6-Dichloro-3,5-dimethoxyaniline 95% | 872509-56-3 | 1g | $30 | 2026-06-04 | Buy |
2,6-Dichloro-3,5-dimethoxyaniline Chemical Properties, Uses, Production
Chemical Properties
White to off-white powder
Uses
2,6-Dichloro-3,5-dimethoxyaniline is primarily used as an intermediate in the synthesis of pharmaceuticals.
Synthesis
943189-21-7
872509-56-3
N-(2,6-dichloro-3,5-dimethoxyphenyl)acetamide (34.5 g, 131 mmol) was used as a raw material and dissolved in ethanol (600 mL). Subsequently, 2N aqueous potassium hydroxide solution (400 mL) was added to this solution to obtain the reaction mixture. The reaction mixture was heated to 90°C and stirred, and the reaction was kept at reflux for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature, then cooled to 0 °C in an ice water bath and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed with cold ethanol/water (1:1, v/v) mixed solvent and dried to give 2,6-dichloro-3,5-dimethoxyaniline (22.1 g, 76% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d5): δ 6.21 (s, 1H), 5.40 (s, 2H), 3.83 (s, 6H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] Patent: US2016/145240, 2016, A1. Location in patent: Paragraph 0098; 0099
[3] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 36
[4] Patent: WO2016/164754, 2016, A1. Location in patent: Page/Page column 33
[5] Patent: WO2006/420, 2006, A1. Location in patent: Page/Page column 157
2,6-Dichloro-3,5-dimethoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| YouCoChem (Beijing) Chemical Technology Co., Ltd. | 18800159827 | youcochem@163.com | China | 163 | 50 |
| Anqing YanZhi Pharma Discovery Co.,Ltd. | 18055651951 | 2272561977@qq.com | China | 442 | 58 |
| Shanghai PharmOrgsyn Technology Co., LTD. | 021-+86-021-38228826 | sales@pharmorgsyn.cn | China | 250 | 58 |
| Shanghai Famo Biotechnology Co., Ltd. | 021-36680037 19375184386 | sunshiqi@famobiotech.com | China | 473 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2,6-Dichloro-3,5-dimethoxyaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Benzenamine, 2,?6-?dichloro-?3,?5-?dimethoxy-
872509-56-3
|
$1.00 | 300g | 99.8% | 20 TONS | .GZ HONESTCHEM CO.,LTD | |
 |
2026-09-02 | 2,6-dichloro-3,5-dimethoxyaniline
872509-56-3
|
20kg | 99% | 20 tons | Qingdao RENAS Polymer Material Co., Ltd. | ||
 |
2025-12-24 | 2,6-Dichloro-3,5-dimethoxyaniline
872509-56-3
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Benzenamine, 2,?6-?dichloro-?3,?5-?dimethoxy-
872509-56-3
- $1.00
- 99.8%
- .GZ HONESTCHEM CO.,LTD
-
- 2,6-dichloro-3,5-dimethoxyaniline
872509-56-3
- $0.00
- 99%
- Qingdao RENAS Polymer Material Co., Ltd.
-
- 2,6-Dichloro-3,5-dimethoxyaniline
872509-56-3
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
