4-Bromo-2-fluoro-5-methylpyridine
- CAS No.
- 1227577-02-7
- Chemical Name:
- 4-Bromo-2-fluoro-5-methylpyridine
- Synonyms
- 4-Bromo-2-fluoro-5-methylpyridine;Pyridine, 4-bromo-2-fluoro-5-methyl-
- CBNumber:
- CB32658460
- Molecular Formula:
- C6H5BrFN
- Molecular Weight:
- 190.01
- MDL Number:
- MFCD16609965
- MOL File:
- 1227577-02-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-Bromo-2-fluoro-5-methylpyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CZB57702 | 4-Bromo-2-fluoro-5-methyl-pyridine | 1227577-02-7 | 2.5g | $501.5 | 2026-06-04 | Buy |
| Activate Scientific | AS146963 | 4-Bromo-2-fluoro-5-methylpyridine 95% | 1227577-02-7 | 1g | $169 | 2026-06-04 | Buy |
| Activate Scientific | AS146963 | 4-Bromo-2-fluoro-5-methylpyridine 95% | 1227577-02-7 | 5g | $548 | 2026-06-04 | Buy |
| Matrix Scientific | 201649 | 4-Bromo-2-fluoro-5-methyl-pyridine | 1227577-02-7 | 1.00g | $99 | 2026-05-18 | Buy |
| Matrix Scientific | 201649 | 4-Bromo-2-fluoro-5-methyl-pyridine | 1227577-02-7 | 5.00g | $481 | 2026-05-18 | Buy |
4-Bromo-2-fluoro-5-methylpyridine Chemical Properties, Uses, Production
Uses
4-Bromo-2-fluoro-5-methylpyridine has properties and potential for diabetes treatment.
Synthesis
17282-01-8
1227577-02-7
General procedure for the synthesis of 4-bromo-2-fluoro-5-methylpyridine from 2-fluoro-3-bromo-5-methylpyridine: To a solution of 2-fluoro-3-bromo-5-methylpyridine (300 mg, 1.596 mmol) in tetrahydrofuran (THF, 10 mL) was added lithium diisopropylammonium (LDA, 2M, 0.8 mL) at -78°C and the reaction mixture was stirred at - 78 °C for 2 hours with stirring. Upon completion of the reaction, the reaction was quenched with 10 mL of water and extracted with ethyl acetate (EtOAc, 10 mL x 3). The organic phases were combined and concentrated to give the crude product. The crude product was purified by fast chromatography (normal phase, silica gel, petroleum ether: ethyl acetate = 0-100%, UV 254 and UV 280 detection) to afford 4-bromo-2-fluoro-5-methylpyridine (130 mg, 43% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δppm: 2.37 (s, 3H), 7.19 (d 1H), 8.05 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 19, p. 6691 - 6703
[2] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00181
4-Bromo-2-fluoro-5-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluoro-5-methylpyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3827 | 58 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14905 | 59 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
