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2-Fluoro-4-Bromo-3-Picoline

2-Fluoro-4-Bromo-3-Picoline Structure
2-Fluoro-4-Bromo-3-Picoline structure
CAS No.
128071-79-4
Chemical Name:
2-Fluoro-4-Bromo-3-Picoline
Synonyms
4-Bromo-2-fluoro-3-methylpyridine;2-Fluoro-4-Bromo-3-Picoline;4-BROMO-2-FLUORO-3-METHYLPYRIDIN;2-Fluoro-4-bromo-3-methylpyridine;bromo-4 fluoro-2 methyl-3 pyridine;Pyridine, 4-bromo-2-fluoro-3-methyl-;2-Fluoro-4-Bromo-3-Picoline ISO 9001：2015 REACH
CBNumber:
CB61032949
Molecular Formula:
C6H5BrFN
Molecular Weight:
190.01
MDL Number:
MFCD09839278
MOL File:
128071-79-4.mol
MSDS File:
SDS
Last updated:2026-05-28 04:22:12
Request For Quotation

2-Fluoro-4-Bromo-3-Picoline Properties

Boiling point 220℃
Density 1.592
Flash point 87℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 1.05±0.10(Predicted)
form Oil
color Colourless

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
RIDADR  UN1993
HS Code  2933399990

2-Fluoro-4-Bromo-3-Picoline price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC445018 4-Bromo-2-fluoro-3-methylpyridine 98% 128071-79-4 250mg $25 2026-06-04 Buy
Apolloscientific PC445018 4-Bromo-2-fluoro-3-methylpyridine 98% 128071-79-4 1g $30 2026-06-04 Buy
Apolloscientific PC445018 4-Bromo-2-fluoro-3-methylpyridine 98% 128071-79-4 5g $134 2026-06-04 Buy
Apolloscientific PC445018 4-Bromo-2-fluoro-3-methylpyridine 98% 128071-79-4 10g $256 2026-06-04 Buy
Apolloscientific PC445018 4-Bromo-2-fluoro-3-methylpyridine 98% 128071-79-4 25g $583 2026-06-04 Buy
Product number Packaging Price Buy
PC445018 250mg $25 Buy
PC445018 1g $30 Buy
PC445018 5g $134 Buy
PC445018 10g $256 Buy
PC445018 25g $583 Buy

2-Fluoro-4-Bromo-3-Picoline Chemical Properties, Uses, Production

Uses

2-Fluoro-4-bromo-3-pyridine is an organic compound that is often used as an intermediate in chemical synthesis, especially in the synthesis of drugs and pesticides.

Synthesis

4-Bromo-2-fluoropyridine

128071-98-7

Iodomethane

74-88-4

2-Fluoro-4-Bromo-3-Picoline

128071-79-4

A solution of lithium diisopropylammonium (LDA, 2M, 8.5 mL) was added slowly and dropwise to a solution of 4-bromo-2-fluoropyridine (2 g, 11.3 mmol) in tetrahydrofuran (THF, 40 mL) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 1 h, followed by dropwise addition of iodomethane (4.8 g, 34 mmol). After continued stirring at -78 °C for 1 h, the reaction mixture was allowed to slowly warm up to room temperature over a period of 1 h. The reaction was completed with the addition of iodomethane (4.8 g, 34 mmol). Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution, followed by the addition of an aqueous solution of ammonium chloride (NH4Cl, 50 mL) at 0 °C and extraction with ethyl acetate (EA, 60 mL x 3). The organic layers were combined, washed with brine (60 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, PE/EtOAc) to afford 2-fluoro-3-methyl-4-bromopyridine (1 g, 47% yield) as a yellow solid.1H-NMR (400 MHz, CDCl3) δppm: 2.35 (s, 3H), 7.36 (d, 1H), 7.86 (d, 1H).

References

[1] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00188

2-Fluoro-4-Bromo-3-Picoline Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluoropyridine Iodomethane Lithium diisopropylamide Tetrahydrofuran

Preparation Products

2-Fluoro-4-Bromo-3-Picoline Suppliers

Global Suppliers ( 115)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9335 55
SynAsst Chemical. 021-60343070 China 12731 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Tianjin Jinyuda Chemical Co., Ltd. 55
T&W GROUP 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Jian Chao Chemical Technology Co., Ltd. 55
SynAsst Chemical. 55
Bide Pharmatech Ltd. 60

View Latest Price from 2-Fluoro-4-Bromo-3-Picoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-4-Bromo-3-Picoline pictures 2026-08-20 2-Fluoro-4-Bromo-3-Picoline
128071-79-4
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited

2-Fluoro-4-Bromo-3-Picoline Spectrum

2-Fluoro-4-Bromo-3-Picoline(128071-79-4)1HNMR

128071-79-4 (2-Fluoro-4-Bromo-3-Picoline) Related Search:

4-broMo-2-fluoropyridine-3-carboxylic acid 3-(2-bromophenoxy)propanoic acid 4-BroMo-2-fluoro-3-iodopyridine 4-Bromo-2-fluoropyridine-3-carboxaldehyde 4-Bromo-2-fluoro-5-nitrophenol
3-Bromo-2-fluoro-5-methylpyridine 2-Fluoro-4-Bromo-3-Picoline 2-FLUORO-5-BROMO-3-PICOLINE 4-Bromo-2-fluoropyridine

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2-Fluoro-4-bromo-3-methylpyridine 2-Fluoro-4-Bromo-3-Picoline 4-BROMO-2-FLUORO-3-METHYLPYRIDIN Pyridine, 4-bromo-2-fluoro-3-methyl- 2-Fluoro-4-Bromo-3-Picoline ISO 9001：2015 REACH bromo-4 fluoro-2 methyl-3 pyridine 4-Bromo-2-fluoro-3-methylpyridine 128071-79-4 Pyridine