5-Bromothiophenesulfonyl chloride
- CAS No.
- 55854-46-1
- Chemical Name:
- 5-Bromothiophenesulfonyl chloride
- Synonyms
- 5-BROMOTHIOPHENE-2-SULFONYL CHLORIDE;SBB003086;AKOS B019399;636223_ALDRICH;AKOS BBS-00004606;BUTTPARK 21\07-09;5-bromothiophene-2;TIMTEC-BB SBB003086;ART-CHEM-BB B019399;5-Bromothiophenesulf
- CBNumber:
- CB3266418
- Molecular Formula:
- C4H2BrClO2S2
- Molecular Weight:
- 261.54
- MDL Number:
- MFCD00084909
- MOL File:
- 55854-46-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 40-44 °C (lit.) |
|---|---|
| Boiling point | 100-102 °C/0.5 mmHg (lit.) |
| Density | 1.985±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | crystalline powder |
| color | Off-white/ faint lemon |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C4H2BrClO2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H |
| InChIKey | WGYBIEOLAFYDEC-UHFFFAOYSA-N |
| SMILES | ClS(=O)(=O)c1ccc(Br)s1 |
| CAS DataBase Reference | 55854-46-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317 | |||||||||
| Precautionary statements | P260-P272-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,Xi,Xn | |||||||||
| Risk Statements | 34-43-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-28A-25-36 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful/Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B Skin Sens. 1 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
5-Bromothiophenesulfonyl chloride price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 636223 | 5-Bromothiophene-2-sulfonyl chloride 97% | 55854-46-1 | 5g | $134 | 2026-04-30 | Buy |
| Sigma-Aldrich | 636223 | 5-Bromothiophene-2-sulfonyl chloride 97% | 55854-46-1 | 25g | $676 | 2023-06-20 | Buy |
| TCI Chemical | B2878 | 5-Bromo-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | 55854-46-1 | 1g | $39 | 2021-12-16 | Buy |
| TCI Chemical | B2878 | 5-Bromo-2-thiophenesulfonyl Chloride >98.0%(GC)(T) | 55854-46-1 | 5g | $77 | 2021-12-16 | Buy |
| AstaTech | 56142 | 5-BROMO-THIOPHENE-2-SULFONYL CHLORIDE 95% | 55854-46-1 | 25G | $45 | 2026-04-30 | Buy |
5-Bromothiophenesulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
light yellow crystalline low melting solid
Uses
5-Bromothiophene-2-sulfonyl chloride serves as a starting material for the synthesis of sulfonamide compounds[1]. The reagent reacts with 4-chloroanisole to yield the corresponding sulfone product, and couples with 2-aminobenzoic acid in acetone at room temperature using DMAP[1][3]. It functionalizes m-THPP via sulfonate linkers in dry THF with K2CO3, where base selection and temperature control the distribution of mono- and tetrasubstituted derivatives[2]. The compound acts as a sulfonylating agent in dichloromethane with triethylamine, and reacts with glycine tert-butyl ester hydrochloride in a dioxane/water mixture containing Et3N[4][5].
References
[1]
Liu, J.-P., Zheng, Y.-B. (2007). 5-Bromothiophene-2-sulfonic acid. Acta Crystallographica Section E Structure Reports Online, 63(9), o3697–o3697. https://doi.org/10.1107/s1600536807037208
[2]
Shaker, Y. M., Omar, M. A., Grover, N., Senge, M. O. (2022). Facile synthesis of porphyrin-conjugates as amphiphilic modified photosensitizer structures of m-THPP bearing carbamate, carboxylate and sulfonate linkers. Journal of Porphyrins and Phthalocyanines, 26(10), 638–647. https://doi.org/10.1142/s1088424622500468
[3]
Garzya, V., Forbes, I. T., Lauru, S., Maragni, P. (2004). Indium(III)-catalysed aryl sulfonylation reactions. Tetrahedron Letters, 45(7), 1499–1501. https://doi.org/10.1016/j.tetlet.2003.12.028
[4]
Dai, Z., Yang, X., Li, Y., Bai, C., Wang, K., Huang, J., Wen, X., Wu, X., Ding, J., Peng, T., He, Y. (2026). Discovery and synthesis of phenylthiophene sulfonamide derivatives with promising anti-inflammatory activity. RSC Advances, 16(37), 40019–40034. https://doi.org/10.1039/d6ra03406c
[5]
Nuti, E., Casalini, F., Santamaria, S., Gabelloni, P., Bendinelli, S., Pozzo, E. D., Costa, B., Marinelli, L., Pietra, V. L., Novellino, E., Bernardo, M. M., Fridman, R., Settimo, F. D., Martini, C., Rossello, A. (2011). Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. European Journal of Medicinal Chemistry, 46(7), 2617–2629. https://doi.org/10.1016/j.ejmech.2011.03.033
5-Bromothiophenesulfonyl chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Lastest Price from 5-Bromothiophenesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Bromothiophenesulfonyl chloride
55854-46-1
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 5-Bromothiophenesulfonyl chloride
55854-46-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-02-19 | 5-Bromo-thiophene-2-sulfonyl chloride
55854-46-1
|
$890.00 | 1g | 96 | 500 Kg | R&D Scientific Inc. |
-
- 5-Bromothiophenesulfonyl chloride
55854-46-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromothiophenesulfonyl chloride
55854-46-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Bromo-thiophene-2-sulfonyl chloride
55854-46-1
- $890.00
- 96
- R&D Scientific Inc.
