XL019
- CAS No.
- 945755-56-6
- Chemical Name:
- XL019
- Synonyms
- XL019;XL019, >95%;XL019/XL-019;XL019, >=98%;XL019 USP/EP/BP;XL019, 10 mM in DMSO;XL019; XL-019; XL 019.;XL019 XL-019 JAK2 Inhibitor;(S)-N-(4-(2-(4-MORPHOLINOPHENYLAMINO)PYRIMIDIN-4-YL)PHENYL)PYRROLIDINE-2-CARBOXAMIDE;(2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide
- CBNumber:
- CB32664379
- Molecular Formula:
- C25H28N6O2
- Molecular Weight:
- 444.53
- MDL Number:
- MFCD24386874
- MOL File:
- 945755-56-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| XL019 ≥98% (HPLC) | SML2393 | 5mg | $68.93 |
| XL019 ≥98% (HPLC) | SML2393 | 25mg | $277.95 |
| XL019 ≥90% | 16298 | 1mg | $28 |
| XL019 ≥90% | 16298 | 5mg | $83 |
| XL019 ≥90% | 16298 | 10mg | $152 |
| More product size | |||
| Density | 1.291±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥11.125 mg/mL in DMSO |
| form | solid |
| pka | 13.804±0.70(predicted) |
| color | Green to yellow |
| InChIKey | ISOCDPQFIXDIMS-QHCPKHFHSA-N |
| SMILES | O=C(NC1=CC=C(C=C1)C2=NC(NC3=CC=C(C=C3)N4CCOCC4)=NC=C2)[C@H]5NCCC5 |
| FDA UNII | 4L1AM42NVA |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372 |
| Precautionary statements | P260-P264-P270-P314-P501 |
| target organs | Central nervous system |
| WGK Germany | WGK 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | STOT RE 1 Oral |
XL019 price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2393 | XL019 ≥98% (HPLC) | 945755-56-6 | 5mg | $68.93 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2393 | XL019 ≥98% (HPLC) | 945755-56-6 | 25mg | $277.95 | 2026-04-30 | Buy |
| Cayman Chemical | 16298 | XL019 ≥90% | 945755-56-6 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 16298 | XL019 ≥90% | 945755-56-6 | 5mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 16298 | XL019 ≥90% | 945755-56-6 | 10mg | $152 | 2026-04-30 | Buy |
XL019 Chemical Properties,Uses,Production
Uses
XL019 is used in the synthesis of JAK-2 modulators for the treatment of related diseases.
Biological Activity
XL019 is an ATP-binding site-targeting, orally active JAK2 subtype-selective Janus kinase inhibitor (IC50 in nM = 2.2/JAK2 vs. 134.3/JAK1, 214.2/JAK3, 348.3/TYK2) with much reduced or little activity against 116 other kinases (IC50 in nM = 125.4/PDGFRB, 139.7/FLT3, 225.8/c-KIT, 313.8/p70S6K, 370/MLK1, 375.4/IKKbeta, 483.6/KDR, 546.7/PDGFRA, 554.5/FLT4, 910.5/FLT; IC50 >1 μM toward remaining 106 kinases), CYP (1A2, 2C9, 2D6, 3A4 IC50 ≥20 μM), hERG (IC50 = 16 μM), and P-glycoprotein (IC50 >20 μM). XL019 effectively inhibits cellular STAT1/STAT3 phosphorylation both in HEL92.1.7 cultures (IC50 in nM = 386.4/pStat1 and 695/pStat3) and in HEL92.1.7 xenograft-derived tumor in mice in vivo (oral ED50 in mg/kg = 42/pStat1 and 210/pStat3) with significant HEL92.1.7 tumor suppression efficacy in mice (by 60% and 70% on day 14, respectively, with 200 and 300 mg/kg bid p.o. dosage).
target
JAK2
XL019 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9976 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11674 | 58 |
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