MK 6096
- CAS No.
- 1088991-73-4
- Chemical Name:
- MK 6096
- Synonyms
- Filorexant;MK6096;MK-6096;MK 6096;CS-1825;MK 6096;MK6096;MK-6096(Filorexant);Filorexant(MK-6096);Filorexant, 10 mM in DMSO;filorexant / MK-6096, CID25128145
- CBNumber:
- CB32666757
- Molecular Formula:
- C24H25FN4O2
- Molecular Weight:
- 420.48
- MDL Number:
- MFCD28100674
- MOL File:
- 1088991-73-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 540.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.203±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 2mg/mL; Ethanol: 5mg/mL |
| form | A solid |
| pka | 1.54±0.22(Predicted) |
| color | Off-white to brown |
| FDA UNII | E6BTT8VA5Z |
MK 6096 price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29490 | Filorexant ≥98% | 1088991-73-4 | 5mg | $156 | 2026-04-30 | Buy |
| Cayman Chemical | 29490 | Filorexant ≥98% | 1088991-73-4 | 10mg | $279 | 2026-04-30 | Buy |
| Cayman Chemical | 29490 | Filorexant ≥98% | 1088991-73-4 | 25mg | $464 | 2026-04-30 | Buy |
| Cayman Chemical | 29490 | Filorexant ≥98% | 1088991-73-4 | 50mg | $692 | 2026-04-30 | Buy |
| Usbiological | 450067 | Filorexant | 1088991-73-4 | 1mg | $319 | 2026-06-03 | Buy |
MK 6096 Chemical Properties, Uses, Production
Description
Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 2.5 and 0.31 nM, respectively, for the recombinant human receptors). It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (Kb = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.
Uses
Filorexant is a selective dual orexin receptor antagonist with potent sleep-promoting properties. It has advanced into phase II clinical trials for the treatment of insomnia.
in vivo
Filorexant (MK-6096) dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
References
[1] CHRISTOPHER J. WINROW . Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia[J]. Neuropharmacology, 2012, 62 2: Pages 978-987. DOI: 10.1016/j.neuropharm.2011.10.003
MK 6096 Preparation Products And Raw materials
Raw materials
Preparation Products
MK 6096 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from MK 6096 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Filorexant
1088991-73-4
|
$30.00-118.00 | 99.33% | 10g | TargetMol Chemicals Inc. |
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- Filorexant
1088991-73-4
- $30.00-118.00
- 99.33%
- TargetMol Chemicals Inc.
