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JNJ-42847922

JNJ-42847922 Structure
JNJ-42847922 structure
CAS No.
1293281-49-8
Chemical Name:
JNJ-42847922
Synonyms
Seltorexant (JNJ-42847922);JNJ-42847922;JNJ-42847922,Cid 67116280;Seltorexant, 10 mM in DMSO;[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;(5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone;[5-(4,6-Dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]methanone;(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydro-2-(4,6-dimethylpyrimidin-2-yl)pyrrolo[3,4-c]pyrrol-5(1H)-yl)methanone;Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-;[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE
CBNumber:
CB53369745
Molecular Formula:
C21H22FN7O
Molecular Weight:
407.44
MDL Number:
MFCD31700700
MOL File:
1293281-49-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 18:53:57
Request For Quotation

JNJ-42847922 Properties

Boiling point 667.7±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (613.59 mM)
pka 6.50±0.50(Predicted)
form Solid
color White to yellow
FDA UNII AIS8N3O50B

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Skull and Crossbones (GHS06)
GHS07,GHS06
Signal word  Danger
Hazard statements  H312-H319-H301-H335-H332-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P363-P501

JNJ-42847922 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 41854 JNJ-42847922 ≥98% 1293281-49-8 5mg $83 2026-04-30 Buy
Cayman Chemical 41854 JNJ-42847922 ≥98% 1293281-49-8 10mg $132 2026-04-30 Buy
Cayman Chemical 41854 JNJ-42847922 ≥98% 1293281-49-8 25mg $207 2026-04-30 Buy
Cayman Chemical 41854 JNJ-42847922 ≥98% 1293281-49-8 50mg $372 2026-04-30 Buy
ChemScene CS-0030510 Seltorexant 99.83% 1293281-49-8 5mg $97 2026-06-04 Buy
Product number Packaging Price Buy
41854 5mg $83 Buy
41854 10mg $132 Buy
41854 25mg $207 Buy
41854 50mg $372 Buy
CS-0030510 5mg $97 Buy

JNJ-42847922 Chemical Properties, Uses, Production

Description

Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.

Uses

Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].

in vivo

Seltorexant (JNJ-42847922) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats[1].
The sleep-promoting effects of Seltorexant (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats[1].

Animal Model:Male Sprague-Dawley rats (350-450 g)[1]
Dosage:30 mg/kg
Administration:p.o.; per day for 7 days
Result:The reduced sleep onset (non–rapid eye movement (NREM) latency) and the increased NREM sleep duration were maintained upon 7-day repeated dosing with JNJ-42847922. The prolongation of NREM sleep time was due to a significant increase in NREM bout duration throughout the treatment period assessed on D1 and D7. Rapid eye movement (REM) sleep was only marginally affected on D4 of treatment, resulting in a small but significant reduction in REM sleep latency and an increase in REM sleep duration.

IC 50

human OX2R: 8.0 (pKi); rat OX2R: 8.1 (pKi)

References

[1] Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82. DOI:10.1124/jpet.115.225466

JNJ-42847922 synthesis

1186050-58-7
1293284-71-5
1293281-49-8
Synthesis of JNJ-42847922 from 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid and Pyrrolo[3,4-c]pyrrole, 2-(4,6-dimethyl-2-pyrimidinyl)octahydro-

JNJ-42847922 Preparation Products And Raw materials

Raw materials

Benzoyl chloride, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)- Pyrrolo[3,4-c]pyrrole, 2-(4,6-dimethyl-2-pyrimidinyl)octahydro- 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid 3-Benzyl-3,7-diazabicyclo[3.3.0]octane
2-Boc-hexahydro-pyrrolo[3,4-c]pyrrole 2-Fluoro-6-iodobenzoic acid

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Preparation Products

JNJ-42847922 Suppliers

Global Suppliers ( 78)
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9259 58
HangZhou YuHao Chemical Technology Co., Ltd. 0571-82693216 info@yuhaochemical.com China 1999 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4864 55
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 989 55
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457; 18954159893 demi@pharmachemm.com China 205 58
Shanghai YuanYe Biotechnology Co., Ltd. 18916372613 yanzihan@shyuanye.com China 87240 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Bide Pharmatech Ltd. 60
Finetech Industry Limited 58
HangZhou YuHao Chemical Technology Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghaizehan biopharma technology co., Ltd. 55
Jinan Jianfeng Chemical Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62

View Latest Price from JNJ-42847922 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Seltorexant pictures 2026-10-20 Seltorexant
1293281-49-8
 99% 6000 KG Jinan Jianfeng Chemical Co., Ltd
Seltorexant pictures 2026-08-25 Seltorexant
1293281-49-8
 1g 98% 100 g Xi an Biohorlden Industry Trade Co Ltd
Seltorexant pictures 2026-06-02 Seltorexant
1293281-49-8
 $31.00-72.00 99.90% 10g TargetMol Chemicals Inc.
  • Seltorexant pictures
  • Seltorexant
    1293281-49-8
  • $0.00
  • 99%
  • Jinan Jianfeng Chemical Co., Ltd
  • Seltorexant pictures
  • Seltorexant
    1293281-49-8
  • 98%
  • Xi an Biohorlden Industry Trade Co Ltd
  • Seltorexant pictures
  • Seltorexant
    1293281-49-8
  • $31.00-72.00
  • 99.90%
  • TargetMol Chemicals Inc.

JNJ-42847922 Spectrum

JNJ-42847922(1293281-49-8)1HNMR

1293281-49-8 (JNJ-42847922) Related Search:

JNJ-40411813 JNJ-38431055 JNJ-64619178 JNJ-42847922 Methanone,[5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][4-methoxy-2-(2H-1,2,3-triazol-2-yl)phenyl]-
Seltorexant hydrochloride

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[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE JNJ-42847922 JNJ-42847922,Cid 67116280 [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]- Hypocretin Receptor,JNJ42847922,HCRT Receptor,Orexin Receptor (OX Receptor),Seltorexant,movement,barrier,insomnia,somnolence,eye,blood-brain,inhibit,rapid,selective,sleep,JNJ 42847922,Inhibitor (5-(4,6-Dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone Seltorexant, 10 mM in DMSO (2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)(hexahydro-2-(4,6-dimethylpyrimidin-2-yl)pyrrolo[3,4-c]pyrrol-5(1H)-yl)methanone [5-(4,6-Dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]methanone Seltorexant (JNJ-42847922) 1293281-49-8 API