4-Amino-2-chloro-5-nitrobenzotrifluoride
- CAS No.
- 35375-74-7
- Chemical Name:
- 4-Amino-2-chloro-5-nitrobenzotrifluoride
- Synonyms
- 4-Amino-2-chloro-5-nitrobenzotrifluoride;5-chloro-2-nitro-5-trifluoromethylaniline;5-CHLORO-2-NITRO-4-(TRIFLUOROMETHYL)ANILINE;3-Chloro-6-nitro-4-(trifluoromethyl)Aniline;4-Amino-2-chloro-5-nitrobenzotrifluoride 97%;5-chloro-2-nitro-4-trifluoroMethyl-phenylaMine;5-chloro-4-(trifluoromethyl)-2-nitrobenzenamine;5-Chloro-2-nitro-4-(trifluoromethyl)benzenamine;Benzenamine, 5-chloro-2-nitro-4-(trifluoromethyl)-;5-Chloro-2-nitro-4-(trifluoromethyl)aniline, 2-Amino-4-chloro-5-(trifluoromethyl)nitrobenzene
- CBNumber:
- CB3268331
- Molecular Formula:
- C7H4ClF3N2O2
- Molecular Weight:
- 240.57
- MDL Number:
- MFCD01312277
- MOL File:
- 35375-74-7.mol
- MSDS File:
- SDS
| Melting point | 113 °C |
|---|---|
| Boiling point | 310.7±42.0 °C(Predicted) |
| Density | 1.614±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | -3.78±0.25(Predicted) |
| Appearance | Light brown to yellow Solid |
| Comptox DTXSID | DTXSID30378729 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2826199090 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
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4-Amino-2-chloro-5-nitrobenzotrifluoride price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC0912 | 4-Amino-2-chloro-5-nitrobenzotrifluoride >98% | 35375-74-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC0912 | 4-Amino-2-chloro-5-nitrobenzotrifluoride >98% | 35375-74-7 | 5g | $58 | 2026-06-04 | Buy |
| Apolloscientific | PC0912 | 4-Amino-2-chloro-5-nitrobenzotrifluoride >98% | 35375-74-7 | 25g | $279 | 2026-06-04 | Buy |
| Apolloscientific | PC0912 | 4-Amino-2-chloro-5-nitrobenzotrifluoride >98% | 35375-74-7 | 100g | $908 | 2026-06-04 | Buy |
| Synthonix | C44356 | 5-Chloro-2-nitro-4-(trifluoromethyl)aniline 98% | 35375-74-7 | 250mg | $16 | 2026-05-06 | Buy |
4-Amino-2-chloro-5-nitrobenzotrifluoride Chemical Properties, Uses, Production
Synthesis
We used 5-chloro-2-nitroaniline as a starting material and obtained the intermediate 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE in a relatively high yield through a four-step reaction involving iodination, acetylation protection, trifluoromethylation, and deacetylation. Through continuous experimentation, the yield of the trifluoromethylation step was found to be as high as 78%. The synthesis of 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE mainly involves four steps: iodination, acetylation protection, trifluoromethylation, and deacetylation. The synthetic route is shown in Figure 1.
Synthetic Route of 5-Chloro-2-nitro-4-(trifluoromethyl)aniline
Using 5-chloro-2-nitroaniline and elemental iodine as raw materials, the pesticide intermediate 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE is synthesized through a four-step reaction involving iodination, acetylation protection, trifluoromethylation, and deacetylation. This method has the following outstanding features: ① The raw materials are inexpensive and readily available; ② The reaction conditions are mild and easy to control; ③ The reaction system is simple, and the intermediate is easy to separate and purify; ④ The single-step yield is high, and the overall yield is moderate, showing potential development and application value.
Uses
5-Chloro-2-nitro-4-(trifluoromethyl)aniline is a reagent used in the preparation of fused imidazole biocides.
4-Amino-2-chloro-5-nitrobenzotrifluoride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from 4-Amino-2-chloro-5-nitrobenzotrifluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-02-17 | 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE
35375-74-7
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co | |
|
|
2020-02-17 | 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE
35375-74-7
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE
35375-74-7
- $7.00
- 99%
- Career Henan Chemical Co
-
- 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE
35375-74-7
- $7.00
- 99%
- Career Henan Chemical Co
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