ChemicalBook >> CAS DataBase List >>lesinurad int

lesinurad int

lesinurad int structure

CAS No.: 1533519-85-5

Chemical Name:: lesinurad int

Synonyms: lesinurad int;LSEINURAD INT;Lesinurad INT4;Lesinurad internate 4;Intermediate of lesinurad;4-triazol-3-yl]thio]acetate;Pentanedioicacid,5-oxo-,dimethylester;Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1;Acetic acid, 2-((4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-t...;2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl]

CBNumber:: CB32725616

Molecular Formula:: C18H17N3O2S

Molecular Weight:: 339.41

MDL Number:: MFCD28404620

MOL File:: 1533519-85-5.mol

MSDS File:: SDS

Last updated:2026-05-28 01:10:32

Request For Quotation

lesinurad int Properties

Boiling point	546.4±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
pka	0.56±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
REACH Registrations	Inactive

lesinurad int price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	M59197	Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 97%	1533519-85-5	250mg	$90	2026-05-06	Buy
Synthonix	M59197	Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 97%	1533519-85-5	1g	$160	2026-05-06	Buy
Synthonix	M59197	Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 97%	1533519-85-5	5g	$380	2026-05-06	Buy
Synthonix	M59197	Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate 97%	1533519-85-5	10g	$760	2026-05-06	Buy
aablocks	AA00ABLM	Methyl 2-((4-(4-Cyclopropylnaphthalen-1-Yl)-4H-1,2,4-Triazol-3-Yl)Thio)Acetate 98%	1533519-85-5	1g	$52	2026-05-28	Buy

Product number	Packaging	Price	Buy
M59197	250mg	$90	Buy
M59197	1g	$160	Buy
M59197	5g	$380	Buy
M59197	10g	$760	Buy
AA00ABLM	1g	$52	Buy

lesinurad int Chemical Properties, Uses, Production

Synthesis

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione

1533519-84-4

96-32-2

1533519-85-5

In a 100 mL three-necked round-bottomed flask equipped with a magnetic stirrer and thermometer, 25 mL of N,N-dimethylformamide (DMF) and intermediate (III) (2.67 g, 1-cyclopropyl-4-isothiocyanonaphthalene) were added. After stirring at room temperature until complete dissolution, potassium carbonate (1.45 g) and methyl bromoacetate (1.61 g) were added sequentially. The reaction temperature was controlled at 25°C. After the slow addition, the reaction was continued with stirring for 3 hours. Upon completion of the reaction, 50 mL of water was added to the reaction mixture for dilution, followed by extraction with ethyl acetate (50 mL × 3). The organic phases were combined and the ethyl acetate was removed by concentration using a rotary evaporator. To the concentrated residue, 50 mL of methanol was added and heated to reflux to dissolve the crystals, followed by slow cooling to room temperature for recrystallization. The crystals were collected by filtration and washed with a small amount of cold methanol and dried under vacuum to give 3.22 g of Intermediate (IV) (methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate) in 99.5% yield.

References

[1] Patent: CN105906576, 2016, A. Location in patent: Paragraph 0070; 0071; 0083; 0084
[2] Patent: WO2014/8295, 2014, A1. Location in patent: Paragraph 0254-0262
[3] Patent: CN105399694, 2016, A. Location in patent: Paragraph 0085; 0086; 0087; 0088
[4] Patent: CN107098866, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082; 0083

lesinurad int Preparation Products And Raw materials

Raw materials

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1-broMo-4-cyclopropylnaphthalene (4H-[1,2,4]triazol-3-ylsulfanyl)-acetic acid Methyl ester Methyl bromoacetate N,N-Dimethylformamide

Potassium carbonate

1of2

Preparation Products

RDEA-594 sodiuM

lesinurad int Suppliers

Global Suppliers ( 111)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	281	61
Shanghai Feibo Chemical Technology Co., Ltd	021-58955608,2250286 15921236618	blinkzeng@gmail.com	China	522	62
Synches Co., Ltd.	021-53292253	biz@synches.com	China	199	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Changzhou Joyous Chemical Co., Ltd.	0519-85607258	sales@joyouschem.com	China	292	60
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9509	58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	21-33585366 13311639313	sales@shyrchem.com	China	807	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	+86-28-85122536 85324413	market@astatech.cn	China	8016	55

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
Adamas Reagent, Ltd.	59
Jiangsu Vcare PharmaTech Co., Ltd.	61
Shanghai Feibo Chemical Technology Co., Ltd	62
Synches Co., Ltd.	64
BOC Sciences	65
Changzhou Joyous Chemical Co., Ltd.	60
Shanghai Topbiochem Technology Co., Ltd	58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.	55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.	55

View Latest Price from lesinurad int manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	lesinurad int 1533519-85-5	1KG	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-06-20	lesinurad int 1533519-85-5	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2025-04-04	lesinurad int 1533519-85-5	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

lesinurad int
1533519-85-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

lesinurad int
1533519-85-5
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

lesinurad int
1533519-85-5
98%
Henan Aochuang Chemical Co.,Ltd.

1533519-85-5 (lesinurad int) Related Search:

Lesinurad Impurity 10 Lesinurad Impurity 4 1-cyclopropylnaphthalene Lesinurad Impurity J Lesinurad Impurity 29

Lesinurad Impurity 23 Lesinurad Impurity 5 Sodium Salt 3-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide Lesinurad Impurity 38

Lesinurad Impurity 32 (Mixture of Isomers) Lesinurad Impurity H Lesinurad Impurity 24 Lesinurad Impurity N Lesinurad Impurity 27

RDEA 594 4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione Naphthalene, 1-cyclopropyl-4-isothiocyanato-

1of4

lesinurad int Lesinurad INT4 2-[[4- (4-cyclopropylnaphthalen-1-yl) -4H-1,2,4-triazol-3-yl] thio] methyl acetate Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate Acetic acid, 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetate(for Lesinurad) 2-[[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, methyl ester 4-triazol-3-yl]thio]acetate Methyl 2-[[4-(4-cyclopropylnaphthalen-1-yl)-4H-1 Intermediate of lesinurad 2-[[[4- (4-cyclopropyl-1-naphthalyl) -4H-1,2, 4-triazol-3-yl] thio] -methyl ester LSEINURAD INT Lesinurad internate 4 Acetic acid, 2-((4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-t... 2-1[4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-.methyl ester Pentanedioicacid,5-oxo-,dimethylester 2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl] 2 - [[4- (4-cyclopropyl-naphthalen-1-yl) -4H-1,2,4- triazol-3-yl]thiol] acetate 1533519-85-5