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RDEA-594 sodiuM

RDEA-594 sodiuM Structure
RDEA-594 sodiuM structure
CAS No.
1151516-14-1
Chemical Name:
RDEA-594 sodiuM
Synonyms
CS-651;RDEA-594 sodiuM;Lesinurad sodiuM;Pentanedioicacid,5-oxo-,diethylester;sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate;Sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3- yl)sulfanyl)acetate;Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt;Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1)
CBNumber:
CB22729369
Molecular Formula:
C17H13BrN3O2S.Na
Molecular Weight:
426.26279
MDL Number:
MFCD24444603
MOL File:
1151516-14-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 09:01:00
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RDEA-594 sodiuM Properties

storage temp. Store at -20°C
solubility DMSO:55.5(Max Conc. mg/mL);137.97(Max Conc. mM)
Ethanol:85.0(Max Conc. mg/mL);199.41(Max Conc. mM)
Water:8.0(Max Conc. mg/mL);18.77(Max Conc. mM)
form Solid
color White to off-white
FDA UNII 25UH266CV3

RDEA-594 sodiuM price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth BWB51614 Lesinurad sodium 1151516-14-1 10mg $250 2026-06-04 Buy
Biosynth BWB51614 Lesinurad sodium 1151516-14-1 25mg $281.5 2026-06-04 Buy
Biosynth BWB51614 Lesinurad sodium 1151516-14-1 50mg $449.5 2026-06-04 Buy
Biosynth BWB51614 Lesinurad sodium 1151516-14-1 100mg $719 2026-06-04 Buy
Biosynth BWB51614 Lesinurad sodium 1151516-14-1 250mg $1350 2026-06-04 Buy
Product number Packaging Price Buy
BWB51614 10mg $250 Buy
BWB51614 25mg $281.5 Buy
BWB51614 50mg $449.5 Buy
BWB51614 100mg $719 Buy
BWB51614 250mg $1350 Buy

RDEA-594 sodiuM Chemical Properties, Uses, Production

Uses

Lesinurad sodium is a URAT1 and OAT inhibitor, is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2 μM, respectively.

in vivo

Lesinurad (RDEA594) shows better pharmacokinetics than its pro-drug RDEA806. The 100 mg dose of Lesinurad exhibits a phamacological effect in the range of that produced by 300 mg to 800 mg single doses of RDEA806[3].

References

[1] Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52 DOI:10.1037//0882-7974.4.4.471
[2] Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59. DOI:10.1177/1759720X16646703
[3] L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake ,shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.

RDEA-594 sodiuM synthesis

1533519-92-4
1151516-14-1
Synthesis of RDEA-594 sodiuM from 4-cyclopropylnaphthalen-1-aMine hydrochloride

RDEA-594 sodiuM Preparation Products And Raw materials

Raw materials

4-(4-cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione 1-Cyclopropyl-4-nitronaphthalene 1-aMino-4-cyclopropylnaphthalene oxalate N-(4-Cyclopropyl-1-naphthalenyl)-2-formylhydrazinecarbothioamide tert-Butyl 4-cyclopropylnaphthalen-1-ylcarbamate
1-Naphthalenamine, 4-cyclopropyl- lesinurad int Naphthalene, 1-cyclopropyl-4-isothiocyanato- 1-cyclopropylnaphthalene 4-cyclopropylnaphthalen-1-aMine hydrochloride
1-Bromonaphthalene

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Preparation Products

RDEA-594 sodiuM Suppliers

Global Suppliers ( 79)
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
BEIJING EAGLE SKY PHARMATECH CO., LTD 010-88755821 13911359480;18612220856 sophia_818@126.com China 299 55
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Nanjing Chempioneer Pharmaceutical Co., Ltd. 18068075658 sales@chempioneer.com China 1803 58
Supplier Advantage
Shanghai Hanhong Scientific Co.,Ltd. 64
BOC Sciences 65
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Bide Pharmatech Ltd. 60
BEIJING EAGLE SKY PHARMATECH CO., LTD 55
LETOPHARM LIMITED 58
Nanjing Chempioneer Pharmaceutical Co., Ltd. 58

View Latest Price from RDEA-594 sodiuM manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lesinurad Sodium pictures 2026-09-18 Lesinurad Sodium
1151516-14-1
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Lesinurad Sodium. pictures 2026-09-18 Lesinurad Sodium.
1151516-14-1
 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Lesinurad sodium pictures 2026-07-27 Lesinurad sodium
1151516-14-1
 $31.00-47.00 99.97% 10g TargetMol Chemicals Inc.
  • Lesinurad Sodium pictures
  • Lesinurad Sodium
    1151516-14-1
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Lesinurad Sodium. pictures
  • Lesinurad Sodium.
    1151516-14-1
  • $0.00
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

RDEA-594 sodiuM Spectrum

RDEA-594 sodiuM(1151516-14-1)1HNMR

1151516-14-1 (RDEA-594 sodiuM) Related Search:

Lesinurad Impurity 4 Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, ethyl ester RDEA-594 sodiuM Lesinurad Impurity J RDEA 594
lesinurad int

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Lesinurad sodiuM RDEA-594 sodiuM Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, sodium salt (1:1) sodium 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetate Acetic acid, 2-((5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl)thio)-, sodium salt Sodium 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3- yl)sulfanyl)acetate CS-651 Pentanedioicacid,5-oxo-,diethylester 1151516-14-1 C17H13BrN3NaO2S C17H13BrN3O2SNa