LY2409881
- CAS No.
- 946518-61-2
- Chemical Name:
- LY2409881
- Synonyms
- 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide;2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide;Benzo[b]thiophene-4-carboxamide, 2-[5-chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropyl-;2-{5-chloro-2-[3-(4-methyl-piperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide
- CBNumber:
- CB32744877
- Molecular Formula:
- C24H29ClN6OS
- Molecular Weight:
- 485.04
- MDL Number:
- MOL File:
- 946518-61-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| LY2409881 95+% | CS-3956 | 5mg | $143 |
| LY2409881 95+% | CS-3956 | 10mg | $234 |
| LY2409881 95+% | CS-3956 | 50mg | $845 |
| LY2409881 95+% | CS-3956 | 100mg | $1183 |
| LY2409881 >98.5% | AA01EO7J | 2mg | $160 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
LY2409881 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-3956 | LY2409881 95+% | 946518-61-2 | 5mg | $143 | 2026-06-04 | Buy |
| ChemScene | CS-3956 | LY2409881 95+% | 946518-61-2 | 10mg | $234 | 2026-06-04 | Buy |
| ChemScene | CS-3956 | LY2409881 95+% | 946518-61-2 | 50mg | $845 | 2026-06-04 | Buy |
| ChemScene | CS-3956 | LY2409881 95+% | 946518-61-2 | 100mg | $1183 | 2026-06-04 | Buy |
| aablocks | AA01EO7J | LY2409881 >98.5% | 946518-61-2 | 2mg | $160 | 2026-05-30 | Buy |
LY2409881 Chemical Properties,Uses,Production
Uses
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
in vivo
A well-established xenograft model of DLBCL is used to confirm the activity of LY2409881 in vivo. SCID-beige mice implanted with LY10 cell-derived tumors are given intraperitoneal injections of LY2409881 twice weekly at three different doses: 50, 100, and 200 mg/kg. The treatments are well tolerated, resulting in no death or severe morbidity of the mice. The average tumor volume is graphed as a function of time for each treatment group. The rates of tumor volume growth of the treatment groups are all significantly slower than the untreated control group (P≤0.01)[1].
IC 50
IKK2: 30 nM (IC50)
References
[1] Deng C, et al. The novel IKK2 inhibitor LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45. DOI:10.1158/1078-0432.CCR-14-0384
LY2409881 Preparation Products And Raw materials
Raw materials
Preparation Products
LY2409881 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Moltt Biocem Co., Ltd. | +86-21-38682181 15900741819 | China | 282 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1785 | 58 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
