2-Hydroxy-3-pyrazinecarboxylic acid
- CAS No.
- 20737-42-2
- Chemical Name:
- 2-Hydroxy-3-pyrazinecarboxylic acid
- Synonyms
- 3-HYDROXYPYRAZINE-2-CARBOXYLIC ACID;2-Carboxy-3-hydroxypyrazine;3-Hydroxypyrazine-2-carbo...;3-Hydroxypyrazinecarboxylic acid;2-oxo-1H-pyrazine-3-carboxylicaci;3-Hydroxy-2-pyrazinecarboxylic acid;2-oxo-1H-pyrazine-3-carboxylic acid;2-Hydroxy-3-pyrazinecarboxylic acid;3-hydroxy-2-piperazinecarboxylic acid;3-HYDROXY-PIPERAZINE-2-CARBOXYLIC ACID
- CBNumber:
- CB3276916
- Molecular Formula:
- C5H4N2O3
- Molecular Weight:
- 140.1
- MDL Number:
- MFCD00235136
- MOL File:
- 20737-42-2.mol
| Melting point | 218-220 °C |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 12.72±0.20(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C5H4N2O3/c8-4-3(5(9)10)6-1-2-7-4/h1-2H,(H,7,8)(H,9,10) |
| InChIKey | FJZRUSFQHBBTCC-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=CNC1=O |
| CAS DataBase Reference | 20737-42-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P305+P351+P338 |
| HS Code | 2933998090 |
2-Hydroxy-3-pyrazinecarboxylic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR40047 | 3-Hydroxypyrazine-2-carboxylic acid >98% | 20737-42-2 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR40047 | 3-Hydroxypyrazine-2-carboxylic acid >98% | 20737-42-2 | 25g | $43 | 2026-06-04 | Buy |
| Apolloscientific | OR40047 | 3-Hydroxypyrazine-2-carboxylic acid >98% | 20737-42-2 | 100g | $166 | 2026-06-04 | Buy |
| Apolloscientific | OR40047 | 3-Hydroxypyrazine-2-carboxylic acid >98% | 20737-42-2 | 500g | $802 | 2026-06-04 | Buy |
| Activate Scientific | AS31976 | 3-Hydroxypyrazine-2-carboxylic acid 97% | 20737-42-2 | 25g | $24 | 2026-06-04 | Buy |
2-Hydroxy-3-pyrazinecarboxylic acid Chemical Properties, Uses, Production
Synthesis
5424-01-1
20737-42-2
Example 4: Synthesis of 3-[3-(5-chloro-1H-benzimidazol-2-yl)-azetidin-1-yl]-pyrazine-2-carboxylic acid Step 1. Preparation of 3-hydroxypyrazine-2-carboxylic acid: 3-aminopyrazine-2-carboxylic acid (6.95 g, 0.05 mol) was dissolved in a mixed solution of water (55 mL) and sulfuric acid (55 mL, 3.75 M) and heated to 50 °C. Sodium nitrite solution (18.5 mL, 0.06 mol) was slowly added to this solution and the reaction mixture was subsequently cooled to 12 °C. During the addition, the reaction temperature was maintained in the range of 10-16 °C for 30 minutes. Afterwards, the mixture was heated to boiling over 30 minutes. After completion of the reaction, it was cooled to room temperature and filtered to collect the yellow solid. The resulting solid was dissolved in dilute sodium bicarbonate solution, acidified with 10% hydrochloric acid to precipitate the carboxylic acid product and collected by filtration. The crude product was purified by recrystallization from water to give a yellow-orange crystalline solid (4.1 g, 58% yield).
References
[1] Synthetic Communications, 2010, vol. 40, # 20, p. 2988 - 2999
[2] Patent: WO2011/143129, 2011, A1. Location in patent: Page/Page column 62
[3] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 27 - 32
[4] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44; 45
[5] MedChemComm, 2015, vol. 6, # 7, p. 1311 - 1317
2-Hydroxy-3-pyrazinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 2-Hydroxy-3-pyrazinecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
20737-42-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-29 | 3-hydroxypyrazine-2-carboxylic acid
20737-42-2
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
20737-42-2
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
20737-42-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3-hydroxypyrazine-2-carboxylic acid
20737-42-2
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
20737-42-2
- $1.00
- 98%
- Career Henan Chemical Co
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