3-Aminopyrazine-2-carboxylic acid
- CAS No.
- 5424-01-1
- Chemical Name:
- 3-Aminopyrazine-2-carboxylic acid
- Synonyms
- 3-AMINO-2-PYRAZINECARBOXYLIC ACID;NSC 13148;Deacetylhypnosin;TIMTEC-BB SBB004179;3-Aminopyrazine-2-ca;3-Aminopyrazinoic acid;2-Amino-3-pyrazinecarboxyL;3-AMINOPYRAZINE-2-CARBOXYLIC ACID;3-Aminophrazine-2-carboxylic acid;2-Aminopyrazine-3-carboxylic acid
- CBNumber:
- CB7103665
- Molecular Formula:
- C5H5N3O2
- Molecular Weight:
- 139.11
- MDL Number:
- MFCD00006141
- MOL File:
- 5424-01-1.mol
- MSDS File:
- SDS
| Melting point | 205-210 °C (dec.) (lit.) |
|---|---|
| Boiling point | 255.04°C (rough estimate) |
| Density | 1.4551 (rough estimate) |
| refractive index | 1.5900 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Sparingly) , Methanol (Slightly) |
| pka | 3.65±0.10(Predicted) |
| form | Crystalline Powder |
| color | Yellow-greenish |
| BRN | 124835 |
| InChI | InChI=1S/C5H5N3O2/c6-4-3(5(9)10)7-1-2-8-4/h1-2H,(H2,6,8)(H,9,10) |
| InChIKey | ZAGZIOYVEIDDJA-UHFFFAOYSA-N |
| SMILES | C1(C(O)=O)=NC=CN=C1N |
| LogP | -3.1 at 20℃ and pH7 |
| Surface tension | 73.6mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 5424-01-1(CAS DataBase Reference) |
| FDA UNII | X78B5D12FN |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Aminopyrazine-2-carboxylic acid price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A76982 | 3-Amino-2-pyrazinecarboxylic acid ≥99% | 5424-01-1 | 5g | $23.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | A76982 | 3-Amino-2-pyrazinecarboxylic acid ≥99% | 5424-01-1 | 25g | $42.8 | 2026-04-30 | Buy |
| TCI Chemical | A0848 | 3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T) | 5424-01-1 | 5g | $55 | 2026-04-30 | Buy |
| TCI Chemical | A0848 | 3-Aminopyrazine-2-carboxylic Acid >98.0%(HPLC)(T) | 5424-01-1 | 25g | $163 | 2026-04-30 | Buy |
| Usbiological | A1380-15 | 3-Amino-2-pyrazinecarboxylic Acid (3-Amino-pyrazine-2-carboxylic Acid) | 5424-01-1 | 10g | $340 | 2026-06-03 | Buy |
3-Aminopyrazine-2-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
Pale Brown Crystalline Solid
Uses
Antidiabetic
Synthesis
16298-03-6
5424-01-1
General procedure for the synthesis of 3-aminopyrazine-2-carboxylic acid from methyl 3-aminopyrazine-2-carboxylate: Methyl 3-aminopyrazine-2-carboxylate (2.08 g, 13.6 mmol) was suspended in methanol (40 mL) under nitrogen protection, and treated with 1N aqueous sodium hydroxide (30 mL). The reaction mixture was warmed up to room temperature and stirred for 50 min. Subsequently, methanol (about 45 mL) was partially evaporated under reduced pressure. The resulting mixture was cooled in an ice water bath and 1N aqueous hydrochloric acid solution (70 mL) was slowly added. Initially the mixture appeared as a solution and gradually a precipitate was generated with further addition of acid. The solid product was collected by filtration, washed with water (3 x 10 mL) and finally dried under vacuum to give 1.48 g of the target product 3-aminopyrazine-2-carboxylic acid.
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2320 - 2330
[2] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44
3-Aminopyrazine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YouPeng Chemical Co. Ltd. | 021-69005955 13701776567; | youpengchem@163.com | China | 4153 | 56 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 3-Aminopyrazine-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 3-Aminopyrazine-2-carboxylic acid
5424-01-1
|
1KG | 98%min | 500KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-30 | 3-Aminopyrazine-2-carboxylic acid
5424-01-1
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 3-Aminopyrazine-2-Carboxylic Acid
5424-01-1
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 3-Aminopyrazine-2-carboxylic acid
5424-01-1
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Aminopyrazine-2-carboxylic acid
5424-01-1
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Aminopyrazine-2-Carboxylic Acid
5424-01-1
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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