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1,2,3-1H-Triazole

1,2,3-1H-Triazole Structure
1,2,3-1H-Triazole structure
CAS No.
288-36-8
Chemical Name:
1,2,3-1H-Triazole
Synonyms
1H-1,2,3-TRIAZOLE;1,2,3-TRIAZOLE;2H-1,2,3-Triazole;1h-1,2,3-Trizole;Osotriazole;2H-Triazole;Triazacyclopentadiene;V-triazole;3-Triazole;vic-triazole
CBNumber:
CB3290804
Molecular Formula:
C2H3N3
Molecular Weight:
69.07
MDL Number:
MFCD00014490
MOL File:
288-36-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:12:37
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1,2,3-1H-Triazole Properties

Melting point 23-25 °C(lit.)
Boiling point 203 °C752 mm Hg(lit.)
Density 1.192 g/mL at 25 °C(lit.)
refractive index n20/D 1.498(lit.)
Flash point 225 °F
storage temp. Sealed in dry,Room Temperature
solubility Acetone, Chloroform, Methanol (Slightly)
form Liquid
pka 1.17(at 20℃)
color Clear colorless to yellow
Specific Gravity 1.192
Water Solubility soluble
FreezingPoint 21.0 to 24.0 ℃
BRN 104766
InChI 1S/C2H3N3/c1-2-4-5-3-1/h1-2H,(H,3,4,5)
InChIKey QWENRTYMTSOGBR-UHFFFAOYSA-N
SMILES c1c[nH]nn1
CAS DataBase Reference 288-36-8(CAS DataBase Reference)
FDA UNII EM7554254W
NIST Chemistry Reference 1H-1,2,3-Triazole(288-36-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-63-36-22
Safety Statements  37/39-26-36/37
WGK Germany  3
Hazard Note  Irritant
HS Code  29339900
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Active
NFPA 704
1
2 0

1,2,3-1H-Triazole price More Price(85)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 333662 1H-1,2,3-Triazole 97% 288-36-8 1g $60.1 2026-04-30 Buy
Sigma-Aldrich 333662 1H-1,2,3-Triazole 97% 288-36-8 5g $164 2026-04-30 Buy
TCI Chemical T1880 1H-1,2,3-Triazole >98.0%(T) 288-36-8 5g $115 2026-04-30 Buy
TCI Chemical T1880 1H-1,2,3-Triazole >98.0%(T) 288-36-8 25g $403 2026-04-30 Buy
Usbiological 289639 1H-1,2,3-Triazole Asreported 288-36-8 50g $433 2026-06-03 Buy
Product number Packaging Price Buy
333662 1g $60.1 Buy
333662 5g $164 Buy
T1880 5g $115 Buy
T1880 25g $403 Buy
289639 50g $433 Buy

1,2,3-1H-Triazole Chemical Properties,Uses,Production

Description

1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research1. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam2. It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property3.

Chemical Properties

clear colorless liquid

Uses

A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga l, antibacterial and antiviral activities in bioactive triazoles.

Uses

It effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research

Definition

ChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole.

Synthesis Reference(s)

The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o

General Description

2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.

Synthesis

1,2,3-TRIAZOLE-4,5-DICARBOXYLIC ACID

4546-95-6

1,2,3-1H-Triazole

288-36-8

General procedure for the synthesis of 1,2,3-triazole from 1H-1,2,3-triazole-4,5-dicarboxylic acid: to a 2000 mL four-neck flask was added 1250 mL of pure water and 157.08 g (1.0 mol) of 1H-1,2,3-triazole-4,5-dicarboxylic acid, followed by the addition of 4.71 g (equivalent to 1H-1,2,3-triazole-4,5-dicarboxylic acid 3% by mass) of N,N-diisopropylethylamine. The reaction mixture was heated to 100~110°C under atmospheric pressure and refluxed until the reaction solution was clarified. Refluxing was continued for 1 h. The reaction was monitored by HPLC and terminated when the residue of 1H-1,2,3-triazole-4,5-dicarboxylic acid was less than 1%. After completion of the reaction, filtration was performed. A vacuum pump was used to remove most of the water from the filtrate, which was then replaced with a mechanical pump for high vacuum dehydration. The four-necked flask was mounted on a distillation apparatus and vacuum distillation was carried out, resulting in 66.48 g of 1H-1,2,3-triazole with a molar yield of 96.25% and a GC purity of 99.56%.

References

[1] Patent: CN106946803, 2017, A. Location in patent: Paragraph 0035; 0040; 0041; 0045; 0046; 0050; 0051
[2] Patent: CN105330607, 2016, A. Location in patent: Paragraph 0033; 0034
[3] Chemische Berichte, 1893, vol. 26, p. 2737

1,2,3-1H-Triazole Preparation Products And Raw materials

Raw materials

1,2,3-Triazole-4-carboxylic acid 1,2,3-TRIAZOLE-4,5-DICARBOXYLIC ACID N,N-Diisopropylethylamine

Preparation Products

3H-Azirine 3-(1H-1,2,4-TRIAZOL-1-YL)PROPANOIC ACID 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid FLUCONAZOLE IMPURITY C
4,5-Dibromo-1H-1,2,3-triazole 1H-Isoindole-1,3(2H)-dione, 2-[2-(1H-1,2,3-triazol-1-yl)ethyl]-

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1,2,3-1H-Triazole Suppliers

Global( 571)Suppliers
Supplier Tel Email Country ProdList Advantage
SHANXI XINTIANYUAN PHARMACEUTICAL CO.,LTD. 0358-3521713 Xty001@tychemical.com China 3 58
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd 13970866816; 13732973797 fa@zybiopharma.com China 46 58
Shanghai Song Yuan Chemical Technology Co., Ltd. 010-1234567 18521000990 sonyuanchemical@163.com China 6467 50
Hangzhou Baiji Biotechnology Co., LTD 13615701454 616495203@qq.com China 24 58
Rugao City Yi Fan Pharmaceutical Co., Ltd. 0513-81735836 18862916366 157784193@qq.com China 48 58
nanjingsijiayuanyiyaoyouxiangongsi 13851445453 251077031@qq.com China 58 58
Ningxia Yiming Biomedical Technology Co., Ltd 18754046789 yiming@163.cn China 65 58
Zhengzhou KeYulong chemical products Co., Ltd 17319789407 17319789407 Keyulongchem@163.com China 1996 55
Shanghai Bosi Electronic Materials Co., Ltd. 13916923354 13501880914 13585846964@139.com China 24 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
SHANXI XINTIANYUAN PHARMACEUTICAL CO.,LTD. 58
Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd 58
Shanghai Song Yuan Chemical Technology Co., Ltd. 50
Hangzhou Baiji Biotechnology Co., LTD 58
Rugao City Yi Fan Pharmaceutical Co., Ltd. 58
nanjingsijiayuanyiyaoyouxiangongsi 58
Ningxia Yiming Biomedical Technology Co., Ltd 58
Zhengzhou KeYulong chemical products Co., Ltd 55
Shanghai Bosi Electronic Materials Co., Ltd. 58
J & K SCIENTIFIC LTD. 76

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View Lastest Price from 1,2,3-1H-Triazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3-1H-Triazole pictures 2026-09-02 1,2,3-1H-Triazole
288-36-8
 $1.00-50.00 1KG 99% Henan Fengda Chemical Co., Ltd
1,2,3-1H-Triazole pictures 2026-05-28 1,2,3-1H-Triazole
288-36-8
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
1,2,3-1H-Triazole pictures 2026-03-20 1,2,3-1H-Triazole
288-36-8
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

1,2,3-1H-Triazole Spectrum

1,2,3-1H-Triazole(288-36-8)MS1,2,3-1H-Triazole(288-36-8)1HNMR1,2,3-1H-Triazole(288-36-8)IR11,2,3-1H-Triazole(288-36-8)Raman

288-36-8(1,2,3-1H-Triazole)Related Search:

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LABOTEST-BB LT02056574 1,2,3-1H-TRIAZOLE TRIAZOLE(1,2,3-) 1,2,3-Triazol 1H-1,2,3-Triazol Osotriazole Triazacyclopentadiene V-triazole RIBAVIRIN USP24 1H-1,2,3-Triazole,98% vic-triazole 2H-Triazole 1,2,3-1H-Triazole,97% 3-Triazole 2,3-Diazapyrrole v-Triazole (7CI,8CI) 1H,2H-<1,2,3>TriazoliuMyl-(5)-Zwitterion 1,2,3-Triazole, 97+% 1H-1,2,3-Triazole H-1,2,3-Triazole Fluconazole Impurity 21 1, 2, 3-triazoles JACS-288-36-8 triazole fiona Tazobactam Acid Impurity 23 (1,2,3-1H-Triazole) Tazobactam Impurity 42 1,2,3-1H-Triazole USP/EP/BP 1H-1,2,3-Triazole (9CI, ACI) 1,2,3-1H-TRIAZOLE 99% 1,2,3-TRIAZOLE 1h-1,2,3-Trizole 1H-1,2,3-TRIAZOLE 2H-1,2,3-Triazole 288-36-8 C2H3N3 C2H3N3liquid Heterocyclic Building Blocks Triazoles Building Blocks Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Building Blocks Heterocyclic Building Blocks Triazoles bc0001