4-Chloro-2-fluorobenzenesulfonyl chloride
- CAS No.
- 141337-26-0
- Chemical Name:
- 4-Chloro-2-fluorobenzenesulfonyl chloride
- Synonyms
- 4-chloro benzene sulfonul chloride;2-fluoro-4-Chlorobenzenesulfonyl chloride;4-Chlor0-2-Fluorobenzen sulfonyl chloride;4-Chloro-2-fluorobenzenesulfonyl chloride;4-CHLORO-2-FLUOROBENZENESULPHONYL CHLORIDE;2-Fluoro,4-chloro benzene sulfonul chloride;4-Choro-2-fluorobenzene-1-sulfonyl chloride;Benzenesulfonyl chloride, 4-chloro-2-fluoro-;4-chloro-2-fluorobenzene-1-sulfonyl chloride;4-Chloro-2-fluorobenzenesulphonylchloride97%
- CBNumber:
- CB3293603
- Molecular Formula:
- C6H3Cl2FO2S
- Molecular Weight:
- 229.06
- MDL Number:
- MFCD03094560
- MOL File:
- 141337-26-0.mol
- MSDS File:
- SDS
| Melting point | 34-38 °C(lit.) |
|---|---|
| Boiling point | 257.4±20.0℃ (760 Torr) |
| Density | 1.610±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystals |
| color | White |
| Sensitive | Moisture Sensitive |
| InChI | 1S/C6H3Cl2FO2S/c7-4-1-2-6(5(9)3-4)12(8,10)11/h1-3H |
| InChIKey | ZFZRENUEJCOCRE-UHFFFAOYSA-N |
| SMILES | Fc1cc(Cl)ccc1S(Cl)(=O)=O |
| CAS DataBase Reference | 141337-26-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H318 | |||||||||
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2904990090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| NFPA 704 |
|
4-Chloro-2-fluorobenzenesulfonyl chloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 555983 | 4-Chloro-2-fluorobenzenesulfonyl chloride 97% | 141337-26-0 | 1g | $30 | 2023-06-20 | Buy |
| Usbiological | 267571 | 4-Chloro-2-fluorobenzenesulfonyl chloride Asreported | 141337-26-0 | 2g | $388 | 2026-06-03 | Buy |
| Usbiological | 267571 | 4-Chloro-2-fluorobenzenesulfonyl chloride Asreported | 141337-26-0 | 5g | $603 | 2026-06-03 | Buy |
| Usbiological | 267571 | 4-Chloro-2-fluorobenzenesulfonyl chloride Asreported | 141337-26-0 | 10g | $864 | 2026-06-03 | Buy |
| Activate Scientific | AS48672 | 4-Chloro-2-fluorobenzene-1-sulfonyl chloride 98% | 141337-26-0 | 1g | $44 | 2026-06-04 | Buy |
4-Chloro-2-fluorobenzenesulfonyl chloride Chemical Properties, Uses, Production
Uses
4-Chloro-2-fluorobenzenesulfonyl chloride (4-chloro-2-fluorobenzene-1-sulfonyl chloride) may be used to synthesize [1-(4-chloro-2-fluorophenylsulfonyl) piperidin-4-yl] diphenylmethanol.
Synthesis
57946-56-2
141337-26-0
General procedure for the synthesis of 4-chloro-2-fluorobenzenesulfonyl chloride from 4-chloro-2-fluoroaniline: 1. 4-Chloro-2-fluoroaniline (22.90 g, 151 mmol) was dissolved in 120 mL of acetic acid and 80 mL of concentrated hydrochloric acid was added with stirring. 2. the reaction mixture was cooled to 0 °C and a solution of sodium nitrite (27.2 g, 0.4 mol) dissolved in 40 mL of water was added over 10 minutes. 3. The reaction mixture was stirred at 0 °C for 30 min. 4. in another flask, cuprous chloride (500 mg) was dissolved in 200 mL of acetic acid. 5. The flask was cooled to 0 °C and sulfur dioxide gas was passed into the solution for 40 min. 6. The diazonium salt solution prepared in step 3 was slowly added to the solution containing cuprous chloride and sulfur dioxide over a period of 20 minutes, at which time vigorous gas escape was observed. 7. After the addition, the ice bath is removed and the reaction mixture is allowed to gradually warm to room temperature. 8. The reaction mixture was poured into 500 g of crushed ice and the precipitated solid product was collected, washed and dried to give 26.1 g (73% yield) of 4-chloro-2-fluorobenzenesulfonyl chloride.
References
[1] Patent: US2003/232859, 2003, A1. Location in patent: Page 56
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 22, p. 9539 - 9553
4-Chloro-2-fluorobenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
View Latest Price from 4-Chloro-2-fluorobenzenesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-01 | 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
141337-26-0
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
141337-26-0
- $3.00
- 98%
- Career Henan Chemical Co
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