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3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE structure

CAS No.: 23165-29-9

Chemical Name:: 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE

Synonyms: 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene;3,5-Bis(trifuoromethyl)phenyl isothiocyanate;3,5-Di(trifluor;3,5-Trifluoromethylphenyl isothiocyanate;3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYATE;3,5-DI(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE;3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE;3,5-Bis(trifluoromethyl)phenylisothiocyanate97%;3,5-Di(trifluoromethyl)phenyl isothiocyate, 99%;3,5-Bis(trifluoromethyl)phenylIsothiocyanate>

CBNumber:: CB3305740

Molecular Formula:: C9H3F6NS

Molecular Weight:: 271.18

MDL Number:: MFCD00040838

MOL File:: 23165-29-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:56:33

Product description	Number	Pack Size	Price
3,5-Bis(trifluoromethyl)phenyl isothiocyanate 98%	468517	1g	$42.2
3,5-Bis(trifluoromethyl)phenyl isothiocyanate 98%	468517	5g	$112
3,5-Bis(trifluoromethyl)phenyl Isothiocyanate >98.0%(GC)	I0569	5g	$58
3,5-Bis(trifluoromethyl)phenyl Isothiocyanate >98.0%(GC)	I0569	25g	$206
3,5-Bis(trifluoromethyl)phenyl isothiocyanate 97%	PC3115B	5g	$21
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3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE Properties

Melting point	160℃
Boiling point	63 °C1.5 mm Hg(lit.)
Density	1.485 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5(lit.)
Flash point	228 °F
storage temp.	Storage temp. 2-8°C
form	Liquid
color	Clear yellow
Specific Gravity	1.485
Water Solubility	Hydrolyzes in water.
Sensitive	Moisture Sensitive
BRN	2990816
InChI	InChI=1S/C9H3F6NS/c10-8(11,12)5-1-6(9(13,14)15)3-7(2-5)16-4-17/h1-3H
InChIKey	FXOSSGVJGGNASE-UHFFFAOYSA-N
SMILES	C1(N=C=S)=CC(C(F)(F)F)=CC(C(F)(F)F)=C1
CAS DataBase Reference	23165-29-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P301+P310+P330-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

C,T,Xi

Risk Statements

Safety Statements

22-26-27-36/37/39-45

RIDADR

2810

WGK Germany

Hazard Note

Toxic

HazardClass

6.1

PackingGroup

III

HS Code

29309090

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	468517	3,5-Bis(trifluoromethyl)phenyl isothiocyanate 98%	23165-29-9	1g	$42.2	2026-04-30	Buy
Sigma-Aldrich	468517	3,5-Bis(trifluoromethyl)phenyl isothiocyanate 98%	23165-29-9	5g	$112	2026-04-30	Buy
TCI Chemical	I0569	3,5-Bis(trifluoromethyl)phenyl Isothiocyanate >98.0%(GC)	23165-29-9	5g	$58	2026-04-30	Buy
TCI Chemical	I0569	3,5-Bis(trifluoromethyl)phenyl Isothiocyanate >98.0%(GC)	23165-29-9	25g	$206	2026-04-30	Buy
Apolloscientific	PC3115B	3,5-Bis(trifluoromethyl)phenyl isothiocyanate 97%	23165-29-9	5g	$21	2026-06-04	Buy

Product number	Packaging	Price	Buy
468517	1g	$42.2	Buy
468517	5g	$112	Buy
I0569	5g	$58	Buy
I0569	25g	$206	Buy
PC3115B	5g	$21	Buy

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE Chemical Properties,Uses,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

3,5-Bis(trifluoromethyl)phenyl isothiocyanate has been employed for the following studies:

Chemical derivatization of amino-functionalized model surfaces, amino thiolate on Au, amino siloxane on Si, and polyethylene (PE) foils and films.
Chemical derivatization of self assembled monolayers of ω-amino-4,4′-terphenyl substituted alkanethiols.
Synthesis of ethylene-linked sulfonimidoyl-containing thioureas.
Preparation of pyrrolidine-2-carboxylic acid-{2-[3-(3,5-bistrifluoromethylphenyl)thioureido]phenyl}-amide.

Synthesis

Synthesis of 3,5-bis(trifluoromethyl)phenyl isothiocyanate: 3,5-bis(trifluoromethyl)-4-chloroaniline (25.8g, 132.3mmol), triethylenediamine (44.46g, 396.9mmol) and 135mL toluene were added to a 250mL three-necked flask, and dissolved by stirring at room temperature. Then carbon disulfide (30.06 g, 396.9 mmol) was added dropwise within 2.0 h. After dropping, the reaction was held at 15-25C for 8-10 h. After the reaction was finished, filtration was carried out, and the filter cake was drenched with 20 mL of toluene once and dried, to obtain the yellowish powdery 3,5-bis(trifluoromethyl)-4-chloroaniline dithiocarbonate. The resulting 3-(trifluoromethyl)-4-chloroaniline dithiocarbonate was suspended in 200 mL of chloroform and cooled to -5-0 C with open stirring. Slowly add 60 mL of chloroform dissolved in solid phosgene [bis(trichloromethyl)carbonate, BTC] (12.43 g, 42.0 mmol) dropwise, after dropping, the reaction was carried out in an ice bath for 1 h, and then at room temperature for 1 h. Finally, the reaction was heated to reflux and kept warm for 1.5-2 h. After the reaction, the reaction was cooled down to room temperature, and insoluble material was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 3,5-bis(trifluoromethyl)phenyl 3,5-Bis(trifluoromethyl)phenyl isothiocyanate crude product. After column chromatography (silica gel G, pure petroleum ether elution, concentrated under reduced pressure to obtain light yellow oily liquid 23.5g, purity: 99.6% (GC), bp: 248-251 , yield: 80.5%.

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE Preparation Products And Raw materials

Raw materials

Preparation Products

N-[(1S,2S)-2-aMino-1,2-diphenylethyl]-N'-[3,5-bis(trifluoroMethyl)phenyl]-Thiourea N-[3,5-bis(trifluoromethyl)phenyl]-N’cyclohexylthiourea

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE Suppliers

Global( 210)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1444	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14301	58
Henan Alfa Chemical Co., Ltd	+8618339805032	sale03@alfachem.cn	China	9857	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9628	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +8619957148339	market18@leapchem.com	China	24569	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Henan Alfa Chemical Co., Ltd	58
changzhou huayang technology co., ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-08	3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 23165-29-9	$1.00	1KG	98%	100KG	Career Henan Chemical Co

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE
23165-29-9
$1.00
98%
Career Henan Chemical Co

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE Spectrum

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE(23165-29-9)MS 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE(23165-29-9)¹HNMR 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE(23165-29-9)IR1

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ISOTHIOCYANIC ACID 3,5-BIS(TRIFLUOROMETHYL)PHENYL ESTER 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 3,5-DI(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 3,5-Bis(trifuoromethyl)phenyl isothiocyanate 3,5-Bis(trifluoromethyl)phenyl isothiocyanate, 99+% 3,5-Bis(trifluoromethyl)phenyl isothiocyanate 97% 3,5-Bis(trifluoromethyl)phenylisothiocyanate97% 3,5-Trifluoromethylphenyl isothiocyanate 3,5-Di(trifluoromethyl)phenyl isothiocyanate, 97+% 1,3-Bis(trifluoromethyl)-5-isothiocyanatobenzene 3,5-Bis(trifluoroMethyl)phenyl isothiocyanate, 99+% 1GR 3,5-Di(trifluoromethyl)phenyl isothiocyate, 99% 3,5-Di(trifluor 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYATE 3,5-Bis(trifluoromethyl)phenylIsothiocyanate> 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene,>98% Benzene, 1-isothiocyanato-3,5-bis(trifluoromethyl)- 1-Isothiocyanato-3,5-bis(trifluoromethyl)benzene 23165-29-9 CF32C6H3NCS C9H3F6NS Building Blocks Organic Building Blocks Thiocyanates/Isothiocyanates Sulfur Compounds Building Blocks Chemical Synthesis Organic Building Blocks Sulfur Compounds Fluorine series Organic Building Blocks Sulfur Compounds Thiocyanates/Isothiocyanates Phenyl isocyanate&Phenyl isothiocyanate