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3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline structure

CAS No.: 328-74-5

Chemical Name:: 3,5-Bis(trifluoromethyl)aniline

Synonyms: 3,5-DI(TRIFLUOROMETHYL)ANILINE;MBT-NH2;3,5-Bis(Trifluoro;AKOS BBS-00003710;TIMTEC-BB SBB000690;3,5-Di(trifluorometh;3,5-difluoromethylaniline;3,5-Bis(trifluormethyl)aniline;3,5-BIS(TRIFLUOROMETHYL)AMILINE;3,5-bis(trifluoromethyl)-anilin

CBNumber:: CB3134320

Molecular Formula:: C8H5F6N

Molecular Weight:: 229.12

MDL Number:: MFCD00000394

MOL File:: 328-74-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-20 15:44:50

Product description	Number	Pack Size	Price
3,5-Bis(trifluoromethyl)aniline 97%	193135	10g	$57.6
3,5-Bis(trifluoromethyl)aniline 97%	193135	50g	$121
3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	B1324	10g	$17
3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	B1324	25g	$40
3,5-Bis(trifluoromethyl)aniline 98%	3830-3-13	500g	$155
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3,5-Bis(trifluoromethyl)aniline Properties

Melting point	168.2-169.2 °C
Boiling point	85 °C15 mm Hg(lit.)
Density	1.467 g/mL at 25 °C(lit.)
refractive index	n20/D 1.434(lit.)
Flash point	182 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.15±0.10(Predicted)
form	Liquid
color	Clear light yellow to yellow-brown
Specific Gravity	1.473
Water Solubility	Not miscible in water.
BRN	654318
InChI	1S/C8H5F6N/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H,15H2
InChIKey	CDIDGWDGQGVCIB-UHFFFAOYSA-N
SMILES	Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
CAS DataBase Reference	328-74-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	LLV6H6898J
NIST Chemistry Reference	Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry System	Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,Xn

Risk Statements

33-36/37/38-20/21/22

Safety Statements

26-36/37/39-36

RIDADR

2810

WGK Germany

RTECS

ZE9800000

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29214910

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
1		0

3,5-Bis(trifluoromethyl)aniline price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	193135	3,5-Bis(trifluoromethyl)aniline 97%	328-74-5	10g	$57.6	2026-04-30	Buy
Sigma-Aldrich	193135	3,5-Bis(trifluoromethyl)aniline 97%	328-74-5	50g	$121	2026-04-30	Buy
TCI Chemical	B1324	3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	328-74-5	10g	$17	2026-04-30	Buy
TCI Chemical	B1324	3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	328-74-5	25g	$40	2026-04-30	Buy
SynQuest Laboratories	3830-3-13	3,5-Bis(trifluoromethyl)aniline 98%	328-74-5	500g	$155	2026-05-22	Buy

Product number	Packaging	Price	Buy
193135	10g	$57.6	Buy
193135	50g	$121	Buy
B1324	10g	$17	Buy
B1324	25g	$40	Buy
3830-3-13	500g	$155	Buy

3,5-Bis(trifluoromethyl)aniline Chemical Properties,Uses,Production

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Toluene Nitric acid

Preparation Products

5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE 5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE IMD-0354 4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 5,7-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID

3,5-Bis(trifluoromethyl)phenol 3,5-bis(trifluoromethyl)benzenediazonium 3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE tert-butyl 3,5-bis(trifluoromethyl)phenylcarbamate 2-(2-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]HYDRAZONO)MALONONITRILE

1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea, 97% N1-methyl-3,5-di(trifluoromethyl)aniline

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3,5-Bis(trifluoromethyl)aniline Suppliers

Global( 441)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 3,5-Bis(trifluoromethyl)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-22	3,5-Bis(trifluoromethyl)aniline 328-74-5	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	3,5-Bis(trifluoromethyl)aniline 328-74-5	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	3,5-Bis(trifluoromethyl)aniline 328-74-5	US $0.00-0.00 / KG	1KG	99.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

3,5-Bis(trifluoromethyl)aniline
328-74-5
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3,5-Bis(trifluoromethyl)aniline
328-74-5
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3,5-Bis(trifluoromethyl)aniline
328-74-5
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu New Materials Co. Ltd

3,5-Bis(trifluoromethyl)aniline Spectrum

3,5-Bis(trifluoromethyl)aniline(328-74-5)MS 3,5-Bis(trifluoromethyl)aniline(328-74-5)¹HNMR 3,5-Bis(trifluoromethyl)aniline(328-74-5)¹⁹FNMR 3,5-Bis(trifluoromethyl)aniline(328-74-5)IR1 3,5-Bis(trifluoromethyl)aniline(328-74-5)Raman

328-74-5(3,5-Bis(trifluoromethyl)aniline)Related Search:

3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOTHIOCYANATE 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2,5-DIMETHYL-1H-PYRROLE 3,5-Bis(trifluoromethyl)aniline 1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2-THIOUREA 3,5-BIS(TRIFLUOROMETHYL)ACETANILIDE

1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]PYRROLE 3,5-BIS(TRIFLUOROMETHYL)PHENYL ISOCYANATE 3,5-BIS(TRIFLUOROMETHYL)PHENYLHYDRAZINE 2,5-Bis(trifluoromethyl)nitrobenzene 4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-3-THIOSEMICARBAZIDE

Aniline 2,5-Bis(trifluoromethyl)aniline 2-CHLORO(BIS-3',5'-TRIFLUOROMETHYLACETANILIDE) N1-[2-(2-PIPERIDYL)ETHYL]-3,5-DI(TRIFLUOROMETHYL)ANILINE 2-AMINO-4-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO-1,3,5-TRIAZINE

2-BROMO-4,5-DI(TRIFLUOROMETHYL)ANILINE 2-METHYL-3,5-DI(TRIFLUOROMETHYL)ANILINE N1-methyl-3,5-di(trifluoromethyl)aniline

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,,,’,’,’-Hexafluoro-3,5-xylidine ,5-Bis-trifluoromethyl-phenylamine ,5-Xylidine, a,a,a,a',a',a'-hexafluoro- ,a,a,a',a',a'-Hexafluoro-3,5-xylidine 3,5-bis(trifluoromethyl)-anilin 3,5-bis(trifluoromethyl)-benzenamin 3,5-Bis(trifluoromethyl)benzenamine 3,5-Di(trifluorometh 3,5-DI(TRIFLUOROMETHYL)ANILINE 5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE 3,5-BIS(TRIFLUOROMETHYL)AMILINE 3,5-Bis(trifluoromethyl)aniline, 98+% 3,5-Bis(Trifluoro 5-amino-α,α,α,α',α',α'-hexafluoro-m-xylene 5-Amino-α,α,α,αμ,αμ,αμ-hexafluoro-m-xylene, α,α,α,αμ,αμ,αμ-Hexafluoro-3,5-xylidine 3,5-Bis(trifluoromethyl)benzeneamine 3,5-Bis(trifluoroMethyl)aniline, 98+% 10ML 3,5- two(three fluoroMethyl)aniline 3, 5 - double three fluorine Methylaniline 3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro- 3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro- alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine Aniline, 3,5-bis(trifluoromethyl)- TIMTEC-BB SBB000690 MBT-NH2 ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE AKOS BBS-00003710 A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE 3,5-BIS(TRIFLUOROMETHYL)ANILINE 3,5-Bis(trifluoromethyl)aniline > Benzenamine, 3,5-bis(trifluoromethyl)- α,α,α,α',α',α'-Hexafluor-3,5-xylidin 3,5-Di(trifluoromethyl)aniline CAS NO.328-74-5 3,5-Bis(trifluormethyl)aniline 3,5-difluoromethylaniline 328-74-5 C8H5NF6 Organic Building Blocks Nitrogen Compounds Amines Building Blocks C8 Aniline series Fluorobenzene Anilines, Aromatic Amines and Nitro Compounds Miscellaneous Trifluoromethylbenzene serise