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3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)aniline structure

CAS No.: 328-74-5

Chemical Name:: 3,5-Bis(trifluoromethyl)aniline

Synonyms: 3,5-DI(TRIFLUOROMETHYL)ANILINE;MBT-NH2;3,5-Bis(Trifluoro;AKOS BBS-00003710;TIMTEC-BB SBB000690;3,5-Di(trifluorometh;3,5-difluoromethylaniline;3,5-Bis(trifluormethyl)aniline;3,5-BIS(TRIFLUOROMETHYL)AMILINE;3,5-bis(trifluoromethyl)-anilin

CBNumber:: CB3134320

Molecular Formula:: C8H5F6N

Molecular Weight:: 229.12

MDL Number:: MFCD00000394

MOL File:: 328-74-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:57:45

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3,5-Bis(trifluoromethyl)aniline Properties

Melting point	168.2-169.2 °C
Boiling point	85 °C15 mm Hg(lit.)
Density	1.467 g/mL at 25 °C(lit.)
refractive index	n20/D 1.434(lit.)
Flash point	182 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
pka	2.15±0.10(Predicted)
Specific Gravity	1.473
color	Clear light yellow to yellow-brown
Water Solubility	Not miscible in water.
BRN	654318
InChI	1S/C8H5F6N/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H,15H2
InChIKey	CDIDGWDGQGVCIB-UHFFFAOYSA-N
SMILES	Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
CAS DataBase Reference	328-74-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	LLV6H6898J
NIST Chemistry Reference	Benzenamine, 3,5-bis(trifluoromethyl)-(328-74-5)
EPA Substance Registry System	Benzenamine, 3,5-bis(trifluoromethyl)- (328-74-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,Xn

Risk Statements

33-36/37/38-20/21/22

Safety Statements

26-36/37/39-36

RIDADR

2810

WGK Germany

RTECS

ZE9800000

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29214910

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
1		0

3,5-Bis(trifluoromethyl)aniline price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	193135	3,5-Bis(trifluoromethyl)aniline 97%	328-74-5	10g	$57.6	2026-04-30	Buy
Sigma-Aldrich	193135	3,5-Bis(trifluoromethyl)aniline 97%	328-74-5	50g	$121	2026-04-30	Buy
TCI Chemical	B1324	3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	328-74-5	10g	$17	2026-04-30	Buy
TCI Chemical	B1324	3,5-Bis(trifluoromethyl)aniline >97.0%(GC)	328-74-5	25g	$40	2026-04-30	Buy
ChemScene	CS-W009500	3,5-Di(trifluoromethyl)aniline ≥98%	328-74-5	10g	$12	2026-06-04	Buy

Product number	Packaging	Price	Buy
193135	10g	$57.6	Buy
193135	50g	$121	Buy
B1324	10g	$17	Buy
B1324	25g	$40	Buy
CS-W009500	10g	$12	Buy

3,5-Bis(trifluoromethyl)aniline Chemical Properties, Uses, Production

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

3,5-Bis(trifluoromethyl)aniline was found to be a highly efficient monodentate transient directing group (MonoTDG) for the palladium-catalyzed direct dehydrogenative cross-coupling of benzaldehydes with arenes.

Synthesis

The synthesis of 3,5-Bis(trifluoromethyl)aniline is as follows is as follows：Put 259g (1mol) 3,5-Bis(trifluoromethyl)nitrobenzeneand 500g ethyl acetate into a 1L autoclave, add 5g palladium-carbon as a catalyst, raise the temperature to 60℃, then pass the hydrogen pressure to 2MPa, keep the temperature and react for 20 hours, then cooling, filtration, concentration, and distillation to obtain 3,5-Bis(trifluoromethyl)aniline with a purity of 98.5% and a yield of 87%.

3,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Toluene Nitric acid

Preparation Products

5,7-Bis(trifluoromethyl)-4-hydroxyquinoline 5,7-Bis(trifluoromethyl)-4-chloroquinoline IMD-0354 4-Hydroxy-5,7-bis-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 5,7-Bis(trifluoromethyl)-4-hydroxyquinoline-3-carboxylic acid

3,5-Bis(trifluoromethyl)phenol 3,5-bis(trifluoromethyl)benzenediazonium 3,5-Bis(trifluoromethyl)-N-(bromoacetyl)aniline tert-butyl 3,5-bis(trifluoromethyl)phenylcarbamate 2-(2-[3,5-Bis(trifluoromethyl)phenyl]hydrazono)malononitrile

1-[3,5-Bis(trifluoromethyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea, 97% N1-methyl-3,5-di(trifluoromethyl)aniline

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3,5-Bis(trifluoromethyl)aniline Suppliers

Global Suppliers ( 452)

Supplier	Tel	Email	Country	ProdList	Advantage
Dongyang Qiusuo Medical Technology Co., LTD	17502510579	2785299132@qq.com	China	1557	58
Nanjing Dilu Pharmaceutical Co., Ltd	18014482516 18014482516	977144864@qq.com	China	424	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55

Supplier	Advantage
Dongyang Qiusuo Medical Technology Co., LTD	58
Nanjing Dilu Pharmaceutical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Liaoning Tianhua Chemical Co., Ltd.	69
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Beijing HwrkChemical Technology Co., Ltd	55

View Latest Price from 3,5-Bis(trifluoromethyl)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	3,5-Bis(trifluoromethyl)aniline 328-74-5		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	3,5-Bis(trifluoromethyl)aniline 328-74-5	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	3,5-Bis(trifluoromethyl)aniline 328-74-5		1KG	99.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

3,5-Bis(trifluoromethyl)aniline
328-74-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3,5-Bis(trifluoromethyl)aniline
328-74-5
$5.00
99%
Henan Fengda Chemical Co., Ltd

3,5-Bis(trifluoromethyl)aniline
328-74-5
99.0%
Shaanxi Dideu New Materials Co. Ltd

3,5-Bis(trifluoromethyl)aniline Spectrum

3,5-Bis(trifluoromethyl)aniline(328-74-5)MS 3,5-Bis(trifluoromethyl)aniline(328-74-5)¹HNMR 3,5-Bis(trifluoromethyl)aniline(328-74-5)¹⁹FNMR 3,5-Bis(trifluoromethyl)aniline(328-74-5)IR1 3,5-Bis(trifluoromethyl)aniline(328-74-5)Raman

328-74-5 (3,5-Bis(trifluoromethyl)aniline) Related Search:

3,5-Bis(trifluoromethyl)acetanilide 2,5-Bis(trifluoromethyl)aniline Aniline 2,5-Bis(trifluoromethyl)nitrobenzene 3,5-Bis(trifluoromethyl)aniline

3,5-Bis(trifluoromethyl)phenyl isocyanate 1-[3,5-Bis(trifluoromethyl)phenyl]-2,5-dimethyl-1H-pyrrole 3,5-Bis(trifluoromethyl)phenylhydrazine 3,5-Bis(trifluoromethyl)phenyl isothiocyanate 4-[3,5-Bis(trifluoromethyl)phenyl]-3-thiosemicarbazide

1-[3,5-Bis(trifluoromethyl)phenyl]-2-thiourea 1-[3,5-Bis(trifluoromethyl)phenyl]pyrrole N1-methyl-3,5-di(trifluoromethyl)aniline 2-Bromo-4,5-di(trifluoromethyl)aniline 2-Chloro(bis-3',5'-trifluoromethylacetanilide)

2,6-Bis(trifluoromethyl)aniline N1-[2-(2-Piperidyl)ethyl]-3,5-di(trifluoromethyl)aniline 3,5-Bis(trifluoromethyl)-N-ethylaniline

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,,,’,’,’-Hexafluoro-3,5-xylidine ,5-Bis-trifluoromethyl-phenylamine ,5-Xylidine, a,a,a,a',a',a'-hexafluoro- ,a,a,a',a',a'-Hexafluoro-3,5-xylidine 3,5-bis(trifluoromethyl)-anilin 3,5-bis(trifluoromethyl)-benzenamin 3,5-Bis(trifluoromethyl)benzenamine 3,5-Di(trifluorometh 5-AMINO-ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-M-XYLENE 3,5-BIS(TRIFLUOROMETHYL)AMILINE 3,5-Bis(trifluoromethyl)aniline, 98+% 3,5-Bis(Trifluoro 5-amino-α,α,α,α',α',α'-hexafluoro-m-xylene 5-Amino-α,α,α,αμ,αμ,αμ-hexafluoro-m-xylene, α,α,α,αμ,αμ,αμ-Hexafluoro-3,5-xylidine 3,5-Bis(trifluoromethyl)benzeneamine 3,5-Bis(trifluoroMethyl)aniline, 98+% 10ML 3,5- two(three fluoroMethyl)aniline 3, 5 - double three fluorine Methylaniline 3,5-Xylidine, alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro- 3,5-Xylidine, alpha,alpha,alpha,alpha,alpha,alpha-hexafluro- alpha,alpha,alpha,alpha’,alpha’,alpha’-hexafluoro-5-xylidine Aniline, 3,5-bis(trifluoromethyl)- TIMTEC-BB SBB000690 MBT-NH2 ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-3,5-XYLIDINE AKOS BBS-00003710 A,A,A,A',A',A'-HEXAFLUORO-3,5-XYLIDINE 3,5-BIS(TRIFLUOROMETHYL)ANILINE 3,5-Bis(trifluoromethyl)aniline > Benzenamine, 3,5-bis(trifluoromethyl)- α,α,α,α',α',α'-Hexafluor-3,5-xylidin 3,5-Di(trifluoromethyl)aniline CAS NO.328-74-5 3,5-Bis(trifluormethyl)aniline 3,5-difluoromethylaniline 3,5-DI(TRIFLUOROMETHYL)ANILINE 328-74-5 C8H5NF6 Organic Building Blocks Nitrogen Compounds Amines Building Blocks C8 Aniline series Fluorobenzene Anilines, Aromatic Amines and Nitro Compounds Miscellaneous Trifluoromethylbenzene serise