PCNA-I1
- CAS No.
- 444930-42-1
- Chemical Name:
- PCNA-I1
- Synonyms
- PCNA-I1, 10 mM in DMSO;PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;N'-[(1-hydroxynaphthalen-2-yl) methylidene]-3-methylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
- CBNumber:
- CB33067568
- Molecular Formula:
- C17H14N2O2S
- Molecular Weight:
- 310.37
- MDL Number:
- MOL File:
- 444930-42-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
PCNA-I1 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 444930-42-1 | 5mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 444930-42-1 | 10mg | $143 | 2026-04-30 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 444930-42-1 | 25mg | $333 | 2026-04-30 | Buy |
| Cayman Chemical | 20454 | PCNA-I1 ≥98% | 444930-42-1 | 50mg | $589 | 2026-04-30 | Buy |
| Biosynth | USA93042 | PCNA I1 | 444930-42-1 | 50mg | $1034.5 | 2026-06-05 | Buy |
PCNA-I1 Chemical Properties, Uses, Production
Description
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.
Uses
PCNA-I1 is a potent PCNA (proliferating cell nuclear antigen) inhibitor. PCNA-I1 directly binds PCNA trimers with a Kd of 0.41 μM and exhibits antitumor activity both in vitro and in vivo[1].
References
[1] Tan Z, et al. Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth. Mol Pharmacol. 2012 Jun;81(6):811-9. DOI:10.1124/mol.112.077735
PCNA-I1 Preparation Products And Raw materials
Raw materials
Preparation Products
PCNA-I1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9777 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
