5-(4-Bromophenyl)-5-oxovaleric acid
- CAS No.
- 35333-26-7
- Chemical Name:
- 5-(4-Bromophenyl)-5-oxovaleric acid
- Synonyms
- OTAVA-BB 1043539;UKRORGSYN-BB BBV-213517;4-Bromo-δ-oxobenzenepentanoic acid;5-(4-Bromophenyl)-5-oxovaleric acid;Benzenepentanoic acid, 4-bromo-δ-oxo-
- CBNumber:
- CB3308574
- Molecular Formula:
- C11H11BrO3
- Molecular Weight:
- 271.11
- MDL Number:
- MFCD00672057
- MOL File:
- 35333-26-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
5-(4-Bromophenyl)-5-oxovaleric acid price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | KBA33326 | 5-(4-Bromophenyl)-5-oxovaleric acid | 35333-26-7 | 0.5g | $377.6 | 2026-06-04 | Buy |
| Biosynth | KBA33326 | 5-(4-Bromophenyl)-5-oxovaleric acid | 35333-26-7 | 5g | $1298 | 2026-06-04 | Buy |
| Activate Scientific | AS110543 | 5-(4-Bromophenyl)-5-oxopentanoic acid 97% | 35333-26-7 | 250mg | $133 | 2026-06-04 | Buy |
| Activate Scientific | AS110543 | 5-(4-Bromophenyl)-5-oxopentanoic acid 97% | 35333-26-7 | 1g | $298 | 2026-06-04 | Buy |
| Activate Scientific | AS110543 | 5-(4-Bromophenyl)-5-oxopentanoic acid 97% | 35333-26-7 | 5g | $884 | 2026-06-04 | Buy |
5-(4-Bromophenyl)-5-oxovaleric acid Chemical Properties,Uses,Production
Synthesis
108-55-4
108-86-1
35333-26-7
Anhydrous aluminum trichloride (78.8 mmol, 10.5 g, 2.3 eq.) and anhydrous dichloromethane (25 mL) were added to the flask under a protective tube of calcium chloride and the resulting suspension was stirred in an ice bath. Subsequently, a solution of anhydrous dichloromethane (15 mL) with glutaric anhydride (34.3 mmol, 3.91 g) was added slowly dropwise, keeping the reaction temperature below 7 °C. The reaction was carried out in an ice bath. After the dropwise addition was completed, stirring was continued in an ice bath for 30 min, and then bromobenzene (34.3 mmol, 5.39 g, 1.0 eq.) was carefully added. The ice bath was removed and the reaction mixture was stirred at room temperature for 19 hours. Upon completion of the reaction, the mixture was poured into ice water (15 mL) and acidified with concentrated hydrochloric acid. The aqueous layer was washed with sodium sulfate (10 mL) and the organic phase was extracted with ethyl acetate (1 × 100 mL, 2 × 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was dissolved in ethyl acetate and this solution was added slowly dropwise to cold hexane (1 L) with vigorous stirring. The precipitate was collected by filtration and dried to give 5-(4-bromophenyl)-5-oxovaleric acid (7.93 g, 85%) as a yellow powder with a melting point of 125-127 °C.1H NMR (300 MHz, CDCl3): δ= 2.07 (m, 2H), 2.50 (t, J = 7.2 Hz, 2H), 3.04 (t, J = 7.2 Hz, 2H), 7.60 (m, 2H). 7.60 (m, 2H), 7.82 (m, 2H). 5-(4-Bromophenyl)-5-oxovaleric acid (25.0 mmol, 6.78 g), paraformaldehyde (86.3 mmol, 2.59 g, 3.4 eq.), and piperidine (0.57 mL, 0.24 eq.) were dissolved/suspended in pyridine (42 mL) and stirred for 21 hr. at 70 °C. Upon completion of the reaction, the mixture was poured into a mixture of 1 M sulfuric acid (200 mL) and concentrated hydrochloric acid. The aqueous layer was washed with sodium sulfate (15 mL) and the organic phase was extracted with ethyl acetate (1 × 150 mL, 2 × 100 mL). The organic phases were combined, washed with half-saturated brine (300 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was crystallized with ethyl acetate to give 4-(4-bromobenzoyl)pent-4-enoic acid (3.93 g, 56%) as an orange-yellow solid with a melting point of 127-128 °C. 1H NMR (300 MHz, CDCl3): δ= 2.63 (t, J = 6.9 Hz, 2H), 2.80 (t, J = 6.9 Hz, 2H), 5.67 (s, 1H) , 5.95 (s, 1H), 7.60 (m, 4H); 13C NMR (75 MHz, CDCl3): δ= 27.2, 32.6, 127.3, 127.4, 131.0, 131.6, 136.3, 145.8, 178.9, 196.6.
References
[1] Russian Journal of General Chemistry, 2014, vol. 84, # 9, p. 1825 - 1829
[2] Zhurnal Obshchei Khimii, 2014, vol. 84, # 9, p. 1825 - 1829,5
[3] Tetrahedron Letters, 2016, vol. 57, # 10, p. 1079 - 1082
[4] Heterocycles, 2005, vol. 65, # 3, p. 649 - 656
5-(4-Bromophenyl)-5-oxovaleric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Suzhou Ryan Pharmachem Technology Co.,Ltd | 0512-66585217 13962137180 | sales@ryanchem.com | China | 380 | 55 |
| Shanghai KaiYuLin pharmaceutical technology co., LTD | 021-18721936-595 18721936595 | shkylpharma@126.com | China | 757 | 55 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4991 | 50 |
| Nanjing Huang Tai Pharmaceutical Technology Co. Ltd. | 025-58803135 18551845925 | 3569572487@qq.com | China | 391 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-0371-55629727 13323845623 | 2885676761@qq.com | China | 9948 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| 9ding chemical ( Shanghai) Limited | 021-021-52271985 17721149837 | sales@9dingchem.com | China | 19780 | 60 |
View Lastest Price from 5-(4-Bromophenyl)-5-oxovaleric acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-17 | 5-(4-BROMOPHENYL)-5-OXOVALERIC ACID
35333-26-7
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-(4-BROMOPHENYL)-5-OXOVALERIC ACID
35333-26-7
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
35333-26-7(5-(4-Bromophenyl)-5-oxovaleric acid)Related Search:
1of4
