BAY 58-2667 hydrochloride
- CAS No.
- 646995-35-9
- Chemical Name:
- BAY 58-2667 hydrochloride
- Synonyms
- Cinaciguat HCl;Cinaciguat (hydrochloride);Cinaciguat hydrochloride >=98% (HPLC);BAY 58-2667 hydrochloride - Cinaciguat hydrochloride;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
- CBNumber:
- CB33146261
- Molecular Formula:
- C36H40ClNO5
- Molecular Weight:
- 602.17
- MDL Number:
- MFCD28127267
- MOL File:
- 646995-35-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility |
DMSO:66.74(Max Conc. mg/mL);110.83(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);49.82(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);8.3(Max Conc. mM) |
| form | powder |
| color | white to beige |
| InChIKey | LLHMBJOVHATVSP-UHFFFAOYSA-N |
| SMILES | OC(C(C=C1)=CC=C1CN(CCCCC(O)=O)CCC2=CC=CC=C2OCC3=CC=C(CCC4=CC=CC=C4)C=C3)=O.[H]Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BAY 58-2667 hydrochloride price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1532 | Cinaciguat hydrochloride ≥98% (HPLC) | 646995-35-9 | 5MG | $269 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1532 | Cinaciguat hydrochloride ≥98% (HPLC) | 646995-35-9 | 25MG | $1070 | 2026-04-30 | Buy |
| Cayman Chemical | 17468 | Cinaciguat (hydrochloride) ≥98% | 646995-35-9 | 500μg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 17468 | Cinaciguat (hydrochloride) ≥98% | 646995-35-9 | 1mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 17468 | Cinaciguat (hydrochloride) ≥98% | 646995-35-9 | 5mg | $423 | 2026-04-30 | Buy |
BAY 58-2667 hydrochloride Chemical Properties, Uses, Production
Uses
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
Biochem/physiol Actions
Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.
in vivo
Administration of Cinaciguat decreased BP and increased HR in both apo-sGC mice and WT mice. In fact, the BP-lowering effect of Cinaciguat in apo-sGC mice is significantly greater and longer lasting than in WT mice. In addition, Cinaciguat decreased BP in apo-sGC mice at concentrations that did not affect BP in WT mice. Furthermore, the IC50 values for Cinaciguat-induced ex vivorelaxation of precontracted aortas are threefold lower in apo-sGC mice than in WT mice (IC50=0.2 nM and 0.7 nM, respectively). Together, our results suggest that sGC activators like Cinaciguat but not sGC stimulators like BAY 41-2272 activate apo-sGC. In addition, the observation that Cinaciguat can modulate vasorelaxation and BP in WT mice suggests that even in healthy mice, a subset of the available sGC pool is haem-free and responsive to sGC activators[2].
storage
Store at -20°C
References
[1] Roy B, et al. Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br J Pharmacol. 2008 Apr;153(7):1495-504. DOI:10.1038/sj.bjp.0707687
[2] Thoonen R, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015 Oct 7;6:8482. DOI:10.1038/ncomms9482
BAY 58-2667 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
BAY 58-2667 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1358 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1976 | 58 |
View Latest Price from BAY 58-2667 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Cinaciguat hydrochloride
646995-35-9
|
$112.00-986.00 | 10g | TargetMol Chemicals Inc. |
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- Cinaciguat hydrochloride
646995-35-9
- $112.00-986.00
- TargetMol Chemicals Inc.
