PF 956980
- CAS No.
- 1262832-74-5
- Chemical Name:
- PF 956980
- Synonyms
- PF 956980;PF-00956980;[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-pyrrolidin-1-ylmethanone;Methanone, [(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinyl-
- CBNumber:
- CB33146357
- Molecular Formula:
- C18H26N6O
- Molecular Weight:
- 342.44
- MDL Number:
- MOL File:
- 1262832-74-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
PF 956980 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 019328 | PF-956980 Hydrate | 1262832-74-5 | 10mg | $552 | 2026-06-03 | Buy |
| Biosynth | MAC83274 | Pf-956980 hydrate | 1262832-74-5 | 25mg | $1355 | 2026-06-04 | Buy |
| Biosynth | MAC83274 | Pf-956980 hydrate | 1262832-74-5 | 50mg | $1884.5 | 2026-06-04 | Buy |
| Biosynth | MAC83274 | Pf-956980 hydrate | 1262832-74-5 | 100mg | $3015 | 2026-06-04 | Buy |
| Axon Medchem | Axon2217 | PF 956980 98% | 5mg | $99 | 2026-05-19 | Buy |
PF 956980 Chemical Properties, Uses, Production
Uses
PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent.
Definition
ChEBI: PF-956980 is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 by a methyl[(3R,4R)-4-methyl-1-(pyrrolidin-1-ylcarbonyl)piperidin-3-yl]nitrilo group. It is a potent JAK3-selective chemical probe. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a pyrrolopyrimidine, a tertiary amino compound, a N-acylpiperidine and a N-acylpyrrolidine.
in vivo
The pharmacokinetic parameters of PF-00956980(compound 2) in rat or dog
| Spesies | Dose (mg/kg) | Cl (mL/min/Kg) | Clunbound (mL/min/Kg) | Vss (L/Kg) | Terminal T1/2 (h) | Oral Bioavailability |
| Rat i.v. | 0.5 | 48 | >48,000 | 0.8 | 2.1 | - |
| Rat p.o. | 1 | - | - | - | - | <5% |
| Dog i.v. | 0.1 | 18 | >18,000 | 1.0 | 2.0 | - |
IC 50
JAK1: 2.2 μM (IC50); JAK2: 23.1 μM (IC50); JAK3: 59.9 μM (IC50)
PF 956980 Preparation Products And Raw materials
Raw materials
Preparation Products
PF 956980 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3057 | 58 | |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19087 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
View Latest Price from PF 956980 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | PF-00956980
1262832-74-5
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- PF-00956980
1262832-74-5
- $1520.00-2500.00
- TargetMol Chemicals Inc.
