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ChemicalBook >> CAS DataBase List >>N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Structure
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine structure
CAS No.
1422500-60-4
Chemical Name:
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine
Synonyms
AK0529;RO-0529;Ziresovir;RO-0529(AK0529) Ziresovir;Sialyllactose Impurity 22;N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine;4-Quinazolinamine, N-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5H)-yl)-6-methyl-;4-(4-(((3-Aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide
CBNumber:
CB33147253
Molecular Formula:
C22H25N5O3S
Molecular Weight:
439.53
MDL Number:
MOL File:
1422500-60-4.mol
Last updated:2026-01-05 11:31:08
Product description Number Pack Size Price
Ziresovir 99.86% CS-0086934 5mg $350
Ziresovir 99.86% CS-0086934 10mg $550
Ziresovir 99.86% CS-0086934 25mg $990
Ziresovir 99.86% CS-0086934 50mg $1650
Ziresovir 99.86% CS-0086934 100mg $2250
Request For Quotation

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Properties

Boiling point 745.4±70.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (284.39 mM)
form Solid
pka 7.70±0.20(Predicted)
color White to off-white
FDA UNII XCF42D7AG4

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0086934 Ziresovir 99.86% 1422500-60-4 5mg $350 2021-12-16 Buy
ChemScene CS-0086934 Ziresovir 99.86% 1422500-60-4 10mg $550 2021-12-16 Buy
ChemScene CS-0086934 Ziresovir 99.86% 1422500-60-4 25mg $990 2021-12-16 Buy
ChemScene CS-0086934 Ziresovir 99.86% 1422500-60-4 50mg $1650 2021-12-16 Buy
ChemScene CS-0086934 Ziresovir 99.86% 1422500-60-4 100mg $2250 2021-12-16 Buy
Product number Packaging Price Buy
CS-0086934 5mg $350 Buy
CS-0086934 10mg $550 Buy
CS-0086934 25mg $990 Buy
CS-0086934 50mg $1650 Buy
CS-0086934 100mg $2250 Buy

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Chemical Properties,Uses,Production

Uses

Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species[1].

in vivo

Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) results reduction of RSV titer in mouse lung[1].
Ziresovir (10 mg/kg; p.o.; single dose) exhibits good oral exposure and bioavailability?with F(%) of 32% in male Wistar-Han rats[1].
Ziresovir (150 mg/kg; p.o.; single dose) demonstrates a high tissue distribution to lung than plasma in CD-1 Mice[1].
Pharmacokinetics of Ziresovir in male Wistar-Han rats[1]

Dose (mg/kg)AUC0-24h(p.o.) (ng·h/mL)CL (mL/min/kg)T1/2(i.v.) (h)Vss (L/kg)F (%)
2 mg/kg (iv) or 10 mg/kg (po)906581.23.932
Pharmacokinetics of Ziresovir in CD-1 Mice[1]
Dose (mg/kg)AUC0-24h(p.o.) (μg·h/L)tissue/lasma AUC0-24h ratio (μg·h/L)T1/2 (h)Tmax (h)Cmax (μg/L)
plasma8,38011.020.255090
lung72,4008.63.31122700
Animal Model:Female BALB/c mice infected by RSV[1]
Dosage:12.5 mg/kg, 50 mg/kg
Administration:Oral gavage; twice daily; 4 days
Result:Resulted >1 log unit of viral titer reduction in the lung of infected mice at the dose level as low as 12.5 mg/kg.?
Reduced viral titer to 1.9 log units compared to vehicle at 50 mg/kg dose.

References

[1] Zheng X, et al. Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor. J Med Chem. 2019 Jul 11;62(13):6003-6014. DOI:10.1021/acs.jmedchem.9b00654

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine synthesis

39576-82-4
1422500-60-4
Synthesis of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine from 2,4-DICHLORO-6-METHYLQUINAZOLINE

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

N-(2-(phenylthio)ethyl)acetamide 1-(1,1-dioxido-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)ethan-1-one 2,4-DICHLORO-6-METHYLQUINAZOLINE phenyl-2-aminoethyl sulfide SODIUM THIOPHENOXIDE

Preparation Products

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39042 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Henan Rane Chemical Co., Ltd. 		+8618738066252 info@ranechem.com China 2999 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6886 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1429 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1959 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Henan Rane Chemical Co., Ltd. 		58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Moss Medicine Technology Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58

View Lastest Price from N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ziresovir pictures 2026-01-05 Ziresovir
1422500-60-4
 US $289.00-818.00 / mg 99.92% 10g TargetMol Chemicals Inc.
Ziresovir pictures 2026-01-05 Ziresovir
1422500-60-4
 US $289.00-818.00 / mg 99.92% 10g TargetMol Chemicals Inc.
  • Ziresovir pictures
  • Ziresovir
    1422500-60-4
  • US $289.00-818.00 / mg
  • 99.92%
  • TargetMol Chemicals Inc.
  • Ziresovir pictures
  • Ziresovir
    1422500-60-4
  • US $289.00-818.00 / mg
  • 99.92%
  • TargetMol Chemicals Inc.

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Spectrum

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine(1422500-60-4)1HNMR
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Ziresovir 4-(4-(((3-Aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide AK0529 RO-0529 4-Quinazolinamine, N-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5H)-yl)-6-methyl- Sialyllactose Impurity 22 RO-0529(AK0529) Ziresovir 1422500-60-4