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ChemicalBook >> CAS DataBase List >>N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Structure
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine structure
CAS No.
1422500-60-4
Chemical Name:
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine
Synonyms
Ziresovir;AK0529;RO-0529;RO-0529(AK0529) Ziresovir;Sialyllactose Impurity 22;N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine;4-Quinazolinamine, N-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5H)-yl)-6-methyl-;4-(4-(((3-Aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide
CBNumber:
CB33147253
Molecular Formula:
C22H25N5O3S
Molecular Weight:
439.53
MDL Number:
MOL File:
1422500-60-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Properties

Boiling point 745.4±70.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (284.39 mM)
form Solid
pka 7.70±0.20(Predicted)
color White to off-white
FDA UNII XCF42D7AG4

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth AZ171068 Ziresovir 1422500-60-4 10mg $481.3 2026-06-04 Buy
Biosynth AZ171068 Ziresovir 1422500-60-4 25mg $825 2026-06-04 Buy
Biosynth AZ171068 Ziresovir 1422500-60-4 50mg $1169 2026-06-04 Buy
ChemScene CS-0086934 Ziresovir 95.33% 1422500-60-4 5mg $213 2026-06-04 Buy
ChemScene CS-0086934 Ziresovir 95.33% 1422500-60-4 10mg $325 2026-06-04 Buy
Product number Packaging Price Buy
AZ171068 10mg $481.3 Buy
AZ171068 25mg $825 Buy
AZ171068 50mg $1169 Buy
CS-0086934 5mg $213 Buy
CS-0086934 10mg $325 Buy

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Chemical Properties,Uses,Production

Uses

Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species[1].

in vivo

Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) results reduction of RSV titer in mouse lung[1].
Ziresovir (10 mg/kg; p.o.; single dose) exhibits good oral exposure and bioavailabilitywith F(%) of 32% in male Wistar-Han rats[1].
Ziresovir (150 mg/kg; p.o.; single dose) demonstrates a high tissue distribution to lung than plasma in CD-1 Mice[1].
Pharmacokinetics of Ziresovir in male Wistar-Han rats[1]

Dose (mg/kg)AUC0-24h(p.o.) (ng·h/mL)CL (mL/min/kg)T1/2(i.v.) (h)Vss (L/kg)F (%)
2 mg/kg (iv) or 10 mg/kg (po)906581.23.932
Pharmacokinetics of Ziresovir in CD-1 Mice[1]
Dose (mg/kg)AUC0-24h(p.o.) (μg·h/L)tissue/lasma AUC0-24h ratio (μg·h/L)T1/2 (h)Tmax (h)Cmax (μg/L)
plasma8,38011.020.255090
lung72,4008.63.31122700
Animal Model:Female BALB/c mice infected by RSV[1]
Dosage:12.5 mg/kg, 50 mg/kg
Administration:Oral gavage; twice daily; 4 days
Result:Resulted >1 log unit of viral titer reduction in the lung of infected mice at the dose level as low as 12.5 mg/kg.
Reduced viral titer to 1.9 log units compared to vehicle at 50 mg/kg dose.

References

[1] Zheng X, et al. Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor. J Med Chem. 2019 Jul 11;62(13):6003-6014. DOI:10.1021/acs.jmedchem.9b00654

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine synthesis

39576-82-4
1422500-60-4
Synthesis of N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine from 2,4-Dichloro-6-methylquinazoline

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

N-(2-(phenylthio)ethyl)acetamide 1-(1,1-dioxido-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)ethan-1-one 2,4-Dichloro-6-methylquinazoline phenyl-2-aminoethyl sulfide Sodium thiophenoxide

Preparation Products

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1360 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1965 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9718 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5123 58
Supplier Advantage
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Moss Medicine Technology Co., Ltd. 58
Fan De(Beijing) Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58

View Lastest Price from N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ziresovir pictures 2026-07-27 Ziresovir
1422500-60-4
 $162.00 99.98% 10g TargetMol Chemicals Inc.
Ziresovir pictures 2026-07-27 Ziresovir
1422500-60-4
 $162.00 99.98% 10g TargetMol Chemicals Inc.
  • Ziresovir pictures
  • Ziresovir
    1422500-60-4
  • $162.00
  • 99.98%
  • TargetMol Chemicals Inc.
  • Ziresovir pictures
  • Ziresovir
    1422500-60-4
  • $162.00
  • 99.98%
  • TargetMol Chemicals Inc.

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Spectrum

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine(1422500-60-4)1HNMR

1422500-60-4(N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine)Related Search:

Syncytial Virus Inhibitor-1 N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine FUSION GLYCOPROTEIN F0/F protein, HRSV (AFX60213, SF9, HIS) GLYCOPROTEIN/G protein, HRSV (258A.A, HEK293, HIS) Motavizumab
Verdinexor (KPT-335)

1of2

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine 4-(4-(((3-Aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide RO-0529 4-Quinazolinamine, N-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5H)-yl)-6-methyl- Sialyllactose Impurity 22 RO-0529(AK0529) Ziresovir AK0529 Ziresovir 1422500-60-4