N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

Request For Quotation
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Suppliers list
Company Name: Shanghai Balmxy Pharmaceutical Co., Ltd  
Tel: 021-24206007 13764915196
Email: sales@balmxy.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Dezhou LonWel Pharmaceutical Technology Co., Ltd.  
Tel: 13761310616
Email: 39324283@qq.com
Company Name: Shanghai Moss Medicine Technology Co., Ltd.  
Tel: +86-188369842 +86-15618151133
Email: 188369842@qq.com

N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine manufacturers

  • Ziresovir
  • Ziresovir pictures
  • $162.00
  • 2026-07-27
  • CAS:1422500-60-4
  • Purity: 99.98%
  • Supply Ability: 10g
  • Ziresovir
  • Ziresovir pictures
  • $162.00
  • 2026-07-27
  • CAS:1422500-60-4
  • Purity: 99.98%
  • Supply Ability: 10g
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Basic information
Product Name:N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine
Synonyms:N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine;4-(4-(((3-Aminooxetan-3-yl)methyl)amino)-6-methylquinazolin-2-yl)-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine 1,1-dioxide;RO-0529;4-Quinazolinamine, N-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5H)-yl)-6-methyl-;Sialyllactose Impurity 22;RO-0529(AK0529) Ziresovir;AK0529;Ziresovir
CAS:1422500-60-4
MF:C22H25N5O3S
MW:439.53
EINECS:
Product Categories:
Mol File:1422500-60-4.mol
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Structure
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Chemical Properties
Boiling point 745.4±70.0 °C(Predicted)
density 1.390±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (284.39 mM)
form Solid
pka7.70±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Usage And Synthesis
UsesZiresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species[1].
in vivo

Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) results reduction of RSV titer in mouse lung[1].
Ziresovir (10 mg/kg; p.o.; single dose) exhibits good oral exposure and bioavailabilitywith F(%) of 32% in male Wistar-Han rats[1].
Ziresovir (150 mg/kg; p.o.; single dose) demonstrates a high tissue distribution to lung than plasma in CD-1 Mice[1].
Pharmacokinetics of Ziresovir in male Wistar-Han rats[1]

Dose (mg/kg)AUC0-24h(p.o.) (ng·h/mL)CL (mL/min/kg)T1/2(i.v.) (h)Vss (L/kg)F (%)
2 mg/kg (iv) or 10 mg/kg (po)906581.23.932
Pharmacokinetics of Ziresovir in CD-1 Mice[1]
Dose (mg/kg)AUC0-24h(p.o.) (μg·h/L)tissue/lasma AUC0-24h ratio (μg·h/L)T1/2 (h)Tmax (h)Cmax (μg/L)
plasma8,38011.020.255090
lung72,4008.63.31122700
Animal Model:Female BALB/c mice infected by RSV[1]
Dosage:12.5 mg/kg, 50 mg/kg
Administration:Oral gavage; twice daily; 4 days
Result:Resulted >1 log unit of viral titer reduction in the lung of infected mice at the dose level as low as 12.5 mg/kg.
Reduced viral titer to 1.9 log units compared to vehicle at 50 mg/kg dose.
References[1] Zheng X, et al. Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor. J Med Chem. 2019 Jul 11;62(13):6003-6014. DOI:10.1021/acs.jmedchem.9b00654
N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine Preparation Products And Raw materials
Raw materialsN-(2-(phenylthio)ethyl)acetamide-->1-(1,1-dioxido-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)ethan-1-one-->2,4-DICHLORO-6-METHYLQUINAZOLINE-->phenyl-2-aminoethyl sulfide-->SODIUM THIOPHENOXIDE
Tag:N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine(1422500-60-4) Related Product Information
Syncytial Virus Inhibitor-1 N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine FUSION GLYCOPROTEIN F0/F protein, HRSV (AFX60213, SF9, HIS) GLYCOPROTEIN/G protein, HRSV (258A.A, HEK293, HIS) Motavizumab Verdinexor (KPT-335)