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ChemicalBook >> CAS DataBase List >>17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Structure
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA structure
CAS No.
221246-34-0
Chemical Name:
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA
Synonyms
CMLNDCUXASGBMQ-NQUQXYBYSA-N;17-trifluoromethylphenyl trinor Prostaglandin F2α;17-Trifluoromethylphenyl trinor prostaglandin f2alpha;9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)-
CBNumber:
CB3320675
Molecular Formula:
C24H31F3O5
Molecular Weight:
456.5
MDL Number:
MFCD05863954
MOL File:
221246-34-0.mol
MSDS File:
SDS
Last updated:2026-05-28 03:26:22
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17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Properties

Boiling point 593.0±50.0 °C(Predicted)
Density 1.296±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml
pka 4.76±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
NFPA 704
3
2 0

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16890 17-trifluoromethylphenyl trinor Prostaglandin F2α ≥98% 221246-34-0 1mg $69 2026-04-30 Buy
Cayman Chemical 16890 17-trifluoromethylphenyl trinor Prostaglandin F2α ≥98% 221246-34-0 5mg $297 2026-04-30 Buy
Cayman Chemical 16890 17-trifluoromethylphenyl trinor Prostaglandin F2α ≥98% 221246-34-0 10mg $525 2026-04-30 Buy
ChemScene CS-0066260 17-trifluoromethylphenyl trinor Prostaglandin F2α 221246-34-0 1mg $258 2026-06-04 Buy
ChemScene CS-0066260 17-trifluoromethylphenyl trinor Prostaglandin F2α 221246-34-0 5mg $643 2026-06-04 Buy
Product number Packaging Price Buy
16890 1mg $69 Buy
16890 5mg $297 Buy
16890 10mg $525 Buy
CS-0066260 1mg $258 Buy
CS-0066260 5mg $643 Buy

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Chemical Properties,Uses,Production

Description

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.

Uses

A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.

References

[1] Sorbera, et al. Travoprost. Drugs Future 25(1), 41-45 (2000).

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Preparation Products And Raw materials

Raw materials

Preparation Products

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Chengdu Saiousi Pharmaceutical Co., Ltd 028-64971018 18108168130 China 1780 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Beijing xinyanhui pharmaceutical research and development co., LTD 13969155946 1461866103@qq.com China 16103 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11706 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Easy CDMO Co.,Ltd Info@easycdmo.com 13564957716 Info@easycdmo.com China 9999 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
BOC Sciences 65
Chengdu Saiousi Pharmaceutical Co., Ltd 55
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Beijing xinyanhui pharmaceutical research and development co., LTD 58
JinOu Biomedical (Nanjing) Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Easy CDMO Co.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
17-trifluoromethylphenyl trinor Prostaglandin F2α pictures 2026-05-11 17-trifluoromethylphenyl trinor Prostaglandin F2α
221246-34-0
 $223.00-1720.00 10g TargetMol Chemicals Inc.

221246-34-0(17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA)Related Search:

17-Trifluoromethylphenyl trinor prostaglandin f2alpha 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA 17-trifluoromethylphenyl trinor Prostaglandin F2α isopropyl ester 17-phenoxy trinor Prostaglandin F2α 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

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9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID 17-trifluoromethylphenyl trinor Prostaglandin F2α CMLNDCUXASGBMQ-NQUQXYBYSA-N 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)- (Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid 17-Trifluoromethylphenyl trinor prostaglandin f2alpha 221246-34-0