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17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA manufacturers
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| | 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Basic information |
| Product Name: | 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA | | Synonyms: | 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;17-trifluoromethylphenyl trinor Prostaglandin F2α;CMLNDCUXASGBMQ-NQUQXYBYSA-N;17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, (5Z)-;(Z)-7-((1R,2R,3R,5S)-3,5-Dihydroxy-2-((S,E)-3-hydroxy-5-(3-(trifluoromethyl)phenyl)pent-1-en-1-yl)cyclopentyl)hept-5-enoic acid | | CAS: | 221246-34-0 | | MF: | C24H31F3O5 | | MW: | 456.5 | | EINECS: | | | Product Categories: | | | Mol File: | 221246-34-0.mol |  |
| | 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Chemical Properties |
| Boiling point | 593.0±50.0 °C(Predicted) | | density | 1.296±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | | pka | 4.76±0.10(Predicted) |
| | 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Usage And Synthesis |
| Description | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol. | | Uses | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2α would act very much like the free acid of travoprost. 17-phenyl trinor PGF2α is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol. | | References | [1] Sorbera, et al. Travoprost. Drugs Future 25(1), 41-45 (2000). |
| | 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA Preparation Products And Raw materials |
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