GSK9311
- CAS No.
- 1923851-49-3
- Chemical Name:
- GSK9311
- Synonyms
- GSK9311;GSK 9311;GSK-9311;GSK9311 >=98% (HPLC);GSK 9311 hydrochloride;BRPF1 bromodomain inhibitor GS9311;Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxy-
- CBNumber:
- CB33309536
- Molecular Formula:
- C24H31N5O3
- Molecular Weight:
- 437.53
- MDL Number:
- MOL File:
- 1923851-49-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 625.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.204±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 30 mg/mL (68.57 mM) |
| pka | 8.82±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| optical activity | [α]/D 90 to 100°, c =0.3 in methanol |
| InChIKey | WFXIHQFRQPGCCR-MRXNPFEDSA-N |
| SMILES | O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
GSK9311 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1984 | GSK9311 ≥98% (HPLC) | 1923851-49-3 | 5MG | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1984 | GSK9311 ≥98% (HPLC) | 1923851-49-3 | 25MG | $423 | 2022-05-15 | Buy |
| Biosynth | YBD85149 | GSK9311 | 1923851-49-3 | 25mg | $879.5 | 2026-06-05 | Buy |
| Biosynth | YBD85149 | GSK9311 | 1923851-49-3 | 50mg | $1407 | 2026-06-05 | Buy |
| Biosynth | YBD85149 | GSK9311 | 1923851-49-3 | 100mg | $1958 | 2026-06-05 | Buy |
GSK9311 Chemical Properties, Uses, Production
Uses
GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].
Biological Activity
GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.
GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
IC 50
BRPF1: 6.0 (pIC50); BRPF2: 4.3 (pIC50)
References
[1] Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7. DOI:10.1021/acsmedchemlett.6b00092
GSK9311 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK9311 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
