GSK2245035
- CAS No.
- 1207629-49-9
- Chemical Name:
- GSK2245035
- Synonyms
- AYK003 NO;GSK2245035;GSK2245035 (GSK 2245035;6-Amino-2-((1-methylbutyl)oxy)-9-(5-(1-piperidinyl)pentyl)-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-7,9-dihydro-2-[(1S)-1-methylbutoxy]-9-[5-(1-piperidinyl)pentyl]-
- CBNumber:
- CB33310334
- Molecular Formula:
- C20H34N6O2
- Molecular Weight:
- 390.52
- MDL Number:
- MFCD32008232
- MOL File:
- 1207629-49-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207.4 °C |
|---|---|
| Density | 1.142±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 125 mg/mL (320.09 mM) |
| form | A solid |
| pka | 10.28±0.20(Predicted) |
| color | Off-white to light yellow |
| FDA UNII | 5L3SX16QBQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H361-H302-H335 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
GSK2245035 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33171 | GSK2245035 ≥98% | 1207629-49-9 | 1mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 33171 | GSK2245035 ≥98% | 1207629-49-9 | 5mg | $598 | 2026-04-30 | Buy |
| Cayman Chemical | 33171 | GSK2245035 ≥98% | 1207629-49-9 | 10mg | $1058 | 2026-04-30 | Buy |
| Biosynth | HYB62949 | 6-Amino-2-((1-methylbutyl)oxy)-9-(5-(1-piperidinyl)pentyl)-7,9-dihydro-8H-purin-8-one | 1207629-49-9 | 10mg | $1009 | 2026-06-04 | Buy |
| Biosynth | HYB62949 | 6-Amino-2-((1-methylbutyl)oxy)-9-(5-(1-piperidinyl)pentyl)-7,9-dihydro-8H-purin-8-one | 1207629-49-9 | 25mg | $1645.25 | 2026-06-04 | Buy |
GSK2245035 Chemical Properties, Uses, Production
Uses
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma[1].
in vivo
GSK2245035 (i.n.; 0.03-1 mg/kg; 6 hours) makes dose-related increasing in IFNα levels in serum at doses of 0.3 mg/kg and above at the 2 h time point which had subsided at 6 h[1].
GSK2245035 (3, 30, 300, 3000 ng/kg; 6 hours) treatment can make plasma IP-10 provided the most sensitive biomarker of target engagement with raised levels of this chemokine detected at doses of 30 ng/kg and above in the cynomolgus monkey[1].
| Animal Model: | Female BALB/c mice[1] |
| Dosage: | 0.03, 0.1, 0.3, 1 mg/kg |
| Administration: | Intranasally (i.n.); 6 hours |
| Result: | Dose-related increases in IFNα levels in serum were detected at doses of 0.3 mg/kg and above at the 2 h time point which had subsided at 6 h. |
IC 50
TLR7; IFNα: 9.3 (pEC50); CD40: 6.5 (pEC50)
References
[1] Biggadike K, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016 M DOI:10.1021/acs.jmedchem.5b01647
GSK2245035 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2245035 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29089 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1934 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from GSK2245035 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | GSK2245035
1207629-49-9
|
$272.00-1230.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-27 | GSK2245035
1207629-49-9
|
$272.00-1230.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | GSK2245035
1207629-49-9
|
$272.00-1230.00 | 10g | TargetMol Chemicals Inc. |
-
- GSK2245035
1207629-49-9
- $272.00-1230.00
- TargetMol Chemicals Inc.
-
- GSK2245035
1207629-49-9
- $272.00-1230.00
- TargetMol Chemicals Inc.
-
- GSK2245035
1207629-49-9
- $272.00-1230.00
- TargetMol Chemicals Inc.
1207629-49-9 (GSK2245035) Related Search:
1of2
