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2,5-Dimethyl-2,5-hexanediol

2,5-Dimethyl-2,5-hexanediol Structure
2,5-Dimethyl-2,5-hexanediol structure
CAS No.
110-03-2
Chemical Name:
2,5-Dimethyl-2,5-hexanediol
Synonyms
2,5-DIMETHYLHEXANE-2,5-DIOL;2,5-Hexanediol, 2,5-dimethyl-;1,1,4,4-Tetramethyl-1,4-butanediol;nsc5595;ai3-20685;5-hexanediol;-2,5-hexanedioL;DiMethyl-2,5-hexan;dimethylhexanediol;2,5-Dimethyl-2,5-hex
CBNumber:
CB3335426
Molecular Formula:
C8H18O2
Molecular Weight:
146.23
MDL Number:
MFCD00004473
MOL File:
110-03-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:44:46
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2,5-Dimethyl-2,5-hexanediol Properties

Melting point 86-90 °C (lit.)
Boiling point 214-215 °C (lit.)
Density 0,898 g/cm3
vapor pressure 0.18Pa at 20℃
refractive index 1.4429 (estimate)
Flash point 126 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Flakes
pka 15.07±0.29(Predicted)
color White
Odor mild camphor
Water Solubility SOLUBLE
BRN 1361437
Henry's Law Constant 1.4×101 mol/(m3Pa) at 25℃, Zhang et al. (2010)
InChI 1S/C8H18O2/c1-7(2,9)5-6-8(3,4)10/h9-10H,5-6H2,1-4H3
InChIKey ZWNMRZQYWRLGMM-UHFFFAOYSA-N
SMILES CC(C)(O)CCC(C)(C)O
LogP 0.21 at 23℃
CAS DataBase Reference 110-03-2(CAS DataBase Reference)
FDA UNII 3PNB2S8721
NIST Chemistry Reference 2,5-Hexanediol, 2,5-dimethyl-(110-03-2)
EPA Substance Registry System 2,5-Hexanediol, 2,5-dimethyl- (110-03-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
TSCA  TSCA listed
HS Code  29053980
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Hazardous Substances Data 110-03-2(Hazardous Substances Data)
REACH Registrations Active
NFPA 704
1
3 0

2,5-Dimethyl-2,5-hexanediol price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 143618 2,5-Dimethyl-2,5-hexanediol 97% 110-03-2 100g $53.5 2026-04-30 Buy
Sigma-Aldrich 143618 2,5-Dimethyl-2,5-hexanediol 97% 110-03-2 500g $111 2026-04-30 Buy
TCI Chemical D1167 2,5-Dimethyl-2,5-hexanediol >99.0%(GC) 110-03-2 25g $25 2026-04-30 Buy
TCI Chemical D1167 2,5-Dimethyl-2,5-hexanediol >99.0%(GC) 110-03-2 500g $78 2026-04-30 Buy
Biosynth FD04241 2,5-Dimethyl-2,5-hexanediol 110-03-2 2000g $340 2026-06-04 Buy
Product number Packaging Price Buy
143618 100g $53.5 Buy
143618 500g $111 Buy
D1167 25g $25 Buy
D1167 500g $78 Buy
FD04241 2000g $340 Buy

2,5-Dimethyl-2,5-hexanediol Chemical Properties, Uses, Production

Chemical Properties

Colorless or white crystalline flakes. M.P. 93°C. B.P. 213°C. Soluble in water (20°C 140g/L), miscible with alcohol and most oils. Faint, camphorlike odor.

Uses

2,5-Dimethyl-2,5-hexanediol was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.

Uses

2,5-Dimethyl-2,5-hexanediol is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane to produce polyethylene copolymers and polyethylene rubbers. It is also could be used to prepared nickel-containing Complex Reducing Agents (termed NiCRA)[1].

Preparation

The raw materials 2,5-Dimethyl-3-hexyne-2,5-diol (37.4 g, 263 mmol), ethyl acetate (60 mL), and Pd/C catalyst (0.285 g, 2.63 mmol, 1 mol %) were added to an autoclave. The hydrogen gas was slowly added to 10 bar. When the hydrogenation reaction was performed for 12 hours and then removed the hydrogen gas. Finally, 2,5-Dimethyl-2,5-hexanediol is obtained by purification.
2,5-Dimethyl-2,5-hexanediol

Synthesis Reference(s)

Synthesis, p. 165, 1981 DOI: 10.1055/s-1981-29377

General Description

2,5-Dimethyl-2,5-hexanediol on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.

Purification Methods

Purify the diol by fractional crystallisation. Then the diol is dissolved in hot acetone, treated with activated charcoal, and filtered while hot. The solution is cooled and the diol is filtered off and washed well with cold acetone. The crystallisation process ia repeated several times, and the crystals are dried under a vacuum in a freeze-drying apparatus [Goates et al. J Chem Soc, Faraday Trans 1 78 3045 1982]. [Beilstein 1 IV 2600.]

References

[1] Feghouli G, et al. Activation of reducing agents. Sodium hydride containing complex reducing agents 29. Epimerization of alcohols by nickel-containing complex reducing agents (NiCRA). Tetrahedron Letters, 1988; 9: 285–290.

2,5-Dimethyl-2,5-hexanediol synthesis

142-30-3
110-03-2
Synthesis of 2,5-Dimethyl-2,5-hexanediol from 2,5-Dimethyl-3-hexyne-2,5-diol

2,5-Dimethyl-2,5-hexanediol Preparation Products And Raw materials

Raw materials

2,5-Hexanediol Nickel 3-Hexyne 3-Methyl butynol 2,5-Dimethyl-2-hexanol
2,5-Dimethyl-3-hexyne-2,5-diol 2,5-Dimethylhexane

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Preparation Products

Bexarotene 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene 2,5-Dichloro-2,5-dimethylhexane 1,1,4,4,6-Pentamethyl-1,2,3,4-tetrahydronaphthalene Naphthalene,6-chloro-1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-

2,5-Dimethyl-2,5-hexanediol Suppliers

Global Suppliers ( 443)
Supplier Tel Email Country ProdList Advantage
Sichuan Zhongbang Pharma CO.，LTD 0830-0830-2585019 13679670161 sales2@zhongbangst.com China 105 69
Shandong Kanghong New Material Technology Co., Ltd 17686625089; 17686625089 shandongkanghong@qq.com China 102 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Sichuan Zhongbang Pharma CO.，LTD 69
Shandong Kanghong New Material Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56
Energy Chemical 61

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View Latest Price from 2,5-Dimethyl-2,5-hexanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Dimethyl-2,5-hexanediol pictures 2026-09-17 2,5-Dimethyl-2,5-hexanediol
110-03-2
 1KG 99% 500mt Jinan Finer Chemical Co., Ltd
2,5-Dimethyl-2,5-hexanediol pictures 2026-08-20 2,5-Dimethyl-2,5-hexanediol
110-03-2
 $1.10 1g 99.0% Min 100 Tons Min Dideu Industries Group Limited
2,5-Dimethyl-2,5-hexanediol pictures 2026-05-28 2,5-Dimethyl-2,5-hexanediol
110-03-2
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

2,5-Dimethyl-2,5-hexanediol Spectrum

2,5-Dimethyl-2,5-hexanediol(110-03-2)MS2,5-Dimethyl-2,5-hexanediol(110-03-2)1HNMR2,5-Dimethyl-2,5-hexanediol(110-03-2)13CNMR2,5-Dimethyl-2,5-hexanediol(110-03-2)IR12,5-Dimethyl-2,5-hexanediol(110-03-2)IR22,5-Dimethyl-2,5-hexanediol(110-03-2)IR32,5-Dimethyl-2,5-hexanediol(110-03-2)Raman

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1,1,4,4-Tetramethyl-1,4-butanediol 2,5-dimethyl-5-hexanediol 5-Hexanediol,2,5-dimethyl-2 DiMethyl-2,5-hexan 2,5-Dimethyl-2,5-hex 2,5-DiMethyl-2,5-hexanediol, 99% 250GR 2,5-Dimethyl-2,5-hexanediol,99% 2,5-DiMethyl-2,5-hexanediol, 99.5% 5-hexanediol 2, 5 - diMethyl - 2, 5 - diol 2,5-Dimethyl-2,5-hexanediol 97% ai3-20685 dimethylhexanediol nsc5595 2,5-DIHYDROXY-2,5-DIMETHYLHEXANE 2,5-DIMETHYLHEXAN-2,5-DIOL 2,5-DIMETHYL-2,5-HEXANDIOL 2,5-DIMETHYL-2,5-HEXANEDIOL 2,5-DIMETHYLHEXANEDIOL 2,5-DIMETHYLOHEXANEDIOL 2，5-dimethyl-2，5-hexadiol 7,12-dimethylbenzo[a]anthracene-5,6-dione 2,5-Dimethyl-2,5-hexanediol > 2,5-Dimethyl-2,5-hexanediol Basic information -2,5-hexanedioL 2,5-Dimethyl-2,5-hexanediol, ≥ 99.0% 2,5-DIMETHYLHEXANE-2,5-DIOL 2,5-Hexanediol, 2,5-dimethyl- 110-03-2 1864-01-0 CH3CCH3OHCH2CH2CCH3OHCH3 CH32COHCH2CH2COHCH32 Building Blocks Organic Building Blocks Polyols Oxygen Compounds Organic Building Blocks Oxygen Compounds Polyols Building Blocks Chemical Synthesis Organic Building Blocks Oxygen Compounds bc0001