1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
- CAS No.
- 6683-46-1
- Chemical Name:
- 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
- Synonyms
- 1,1,4,4-Tetramethyltetralin;1,1,4,4-TETRAMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENE;NSC 17400;1,1,4,4-tetramethyl-2,3-dihydronaphthalene;1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-naphthalen;1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE;1,1,4,4-Tetramethyl-1,2,3,4-tetrahydro-naphthalen;naphthalene,1,2,3,4-tetrahydro-1,1,4,4-tetramethyl-;41,1,4,4-Tetramethyl-1,2,3,4-tetrahydro-naphthalene;1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthaline, tech
- CBNumber:
- CB4396352
- Molecular Formula:
- C14H20
- Molecular Weight:
- 188.31
- MDL Number:
- MFCD00052728
- MOL File:
- 6683-46-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | OR30099 | 1g | $21 |
| 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | OR30099 | 5g | $67 |
| 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | OR30099 | 25g | $286 |
| 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | OR30099 | 100g | $905 |
| 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | OR30099 | 500g | $3161 |
| More product size | |||
| Melting point | 115-120℃ |
|---|---|
| Boiling point | 63 °C |
| Density | 0.9482 g/cm3(Temp: 27 °C) |
| refractive index | 1.5278 (589.3 nm 27℃) |
| storage temp. | 2-8°C |
| form | liquid |
| color | Clear, pale yellow |
| InChI | InChI=1S/C14H20/c1-13(2)9-10-14(3,4)12-8-6-5-7-11(12)13/h5-8H,9-10H2,1-4H3 |
| InChIKey | CCQKWSZYTOCEIB-UHFFFAOYSA-N |
| SMILES | C1(C)(C)C2=C(C=CC=C2)C(C)(C)CC1 |
| FDA UNII | YKU41EDL5Y |
| EPA Substance Registry System | Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl- (6683-46-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21-36/37/38 | |||||||||
| Safety Statements | 23-26-36/37/39 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2902900000 | |||||||||
| NFPA 704 |
|
1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR30099 | 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | 6683-46-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR30099 | 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | 6683-46-1 | 5g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR30099 | 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | 6683-46-1 | 25g | $286 | 2026-06-04 | Buy |
| Apolloscientific | OR30099 | 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | 6683-46-1 | 100g | $905 | 2026-06-04 | Buy |
| Apolloscientific | OR30099 | 1,2,3,4-Tetrahydro-1,1,4,4-tetramethylnaphthalene 97% | 6683-46-1 | 500g | $3161 | 2026-06-04 | Buy |
1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene Chemical Properties,Uses,Production
Uses
1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene can be used as an intermediate to participate in a variety of chemical reactions and is used in the synthesis of a variety of compounds and drugs. For example, 6-lodo-1,1,4,4-tetramethyl-l,2,3,4-tetrahydronaphthalene, 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene and 1,1,4,4-tetramethyl-6-nitro-1,2,3,4- tetrahydronaphthalene and others.
Preparation
2,5-dichloro-2,5- dimethylhexane (300 mg, 1.64 mmol, 1 eq) was dissolved in dry benzene (25 mL). Then added AlCl3 (22.0 mg, 0.164 mmol, 0.1 eq) to the solution, which was stirred at reflux for 16 hours. The reaction was stopped with 3M HCl (5 mL) and extracted with hexanes (10 mL x 3). The combined organic layer was washed with brine, dried with Na2S04, filtered, and concentrated in vacuo. Finally, the crude was purified by flash chromatography (100% hexanes) to obtained the colourless oil (1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene).Yield=91%
Synthesis
6223-78-5
71-43-2
6683-46-1
General procedure for the synthesis of 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene from 2,5-dichloro-2,5-dimethylhexane and benzene: 2,5-dichloro-2,5-dimethylhexane (300 mg, 1.64 mmol, 1 eq.) was dissolved in dry benzene (25 mL). To this solution was added anhydrous aluminum trichloride (AlCl3, 22.0 mg, 0.164 mmol, 0.1 eq.) and the reaction mixture was stirred under reflux conditions for 16 hours. Upon completion of the reaction, the reaction was quenched with 3M hydrochloric acid (5 mL) and extracted with hexane (10 mL × 3). The organic layers were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated in vacuum. The crude product was purified by fast column chromatography (100% hexane as eluent) to afford 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene (309 mg, 91% yield) as a colorless oil. The product was characterized as follows: 1H NMR (500 MHz, CDCl3) δ 1.33 (s, 12H), 1.74 (s, 4H), 7.16-7.19 (m, 2H), 7.34-7.36 (m, 2H, J = 2 Hz and 8.4 Hz); 13C NMR (500 MHz, CDCl3) δ 31.9, 34.2, 35.1, 125.5, 13C NMR (500 MHz, CDCl3) δ 31.9, 34.2 35.1, 125.5, 126.5, 144.8.
References
[1] Patent: WO2015/188015, 2015, A1. Location in patent: Page/Page column 31
[2] Patent: WO2018/107289, 2018, A1. Location in patent: Page/Page column 17
[3] Journal of the Brazilian Chemical Society, 2018, vol. 29, # 1, p. 109 - 124
[4] Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2182 - 2192
[5] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 6, p. 1948 - 1959
1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou uniringchem Co., Ltd. | 13585446801 | sales@uniringchem.com | China | 69 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9666 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29094 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
View Lastest Price from 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-26 | 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
6683-46-1
|
$1.00-101.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2020-03-24 | 1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE
6683-46-1
|
$3.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
6683-46-1
- $1.00-101.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE
6683-46-1
- $3.00
- 98%
- Career Henan Chemical Co
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