Propargyl-PEG12-amine
- CAS No.
- 2264091-73-6
- Chemical Name:
- Propargyl-PEG12-amine
- Synonyms
- Propyne-PEG12-NH2;Propargyl-PEG12-amine;Propargyl-PEG13- Amine;3,6,9,12,15,18,21,24,27,30,33,36-Dodecaoxanonatriacont-38-yn-1-amine
- CBNumber:
- CB33373757
- Molecular Formula:
- C27H53NO12
- Molecular Weight:
- 583.71
- MDL Number:
- MOL File:
- 2264091-73-6.mol
Propargyl-PEG12-amine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0115220 | Propargyl-PEG12-amine ≥98% | 2264091-73-6 | 100mg | $192 | 2026-06-04 | Buy |
| ChemScene | CS-0115220 | Propargyl-PEG12-amine ≥98% | 2264091-73-6 | 250mg | $396 | 2026-06-04 | Buy |
| ChemScene | CS-0115220 | Propargyl-PEG12-amine ≥98% | 2264091-73-6 | 1g | $964 | 2026-06-04 | Buy |
| BroadPharm | bp-23543 | Propargyl-PEG12-amine 98% | 2264091-73-6 | 250MG | $340 | 2026-05-24 | Buy |
| BroadPharm | bp-23543 | Propargyl-PEG12-amine 98% | 2264091-73-6 | 500MG | $580 | 2026-05-24 | Buy |
Propargyl-PEG12-amine Chemical Properties, Uses, Production
Chemical Properties
Alkynyl-PEG12-amines are heterobifunctional reagents that form amides with carboxylic acids, activated NHS esters, and carbonyls (ketones, aldehydes). The propargyl group can react with azides via copper-catalyzed azide-alkyne click chemistry to produce stable triazole chain structures.
Uses
Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG12-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
Propargyl-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Propargyl-PEG12-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG12-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alabiochem Tech.Co., Ltd. | 512-58900862 400-0707518 | sales@alabiochem.com | China | 988 | 59 |
| Adachibio Inc. | +81-8027837258; | sales@adachibio.com | Japan | 938 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4229 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Xiamen Sinopeg Biotech Co., Ltd. | 400-9189898 17359873007 | sales@sinopeg.com | China | 1003 | 58 |
| Zhengzhou Converging Chemical Co. LTD | 0371-53399770 18037166334 | 3857571523@qq.com | China | 7219 | 58 |
| shanghai Yanfeng biochemical technology Co.,LTD | 17721070236 13611955358 | yanfen2023@126.com | China | 2995 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9992 | 58 |
| Nanjing Bairuikang Biotechnology Co., Ltd. | 18168036974 | wangweicss@126.com | China | 1379 | 58 |
| Shandong fen Boyu Biotechnology Co.,LTD | 13356310019 13356310019; | boyu2024@163.com | China | 3947 | 58 |
View Latest Price from Propargyl-PEG12-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | Propargyl-PEG12-NH2
2264091-73-6
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2025-06-07 | Propargyl-PEG12-amine
2264091-73-6
|
1g | >95.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG12-NH2
2264091-73-6
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Propargyl-PEG12-amine
2264091-73-6
- $0.00
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
