4-Phenylamino-6,7-dimethoxyquinazoline
- CAS No.
- 21561-09-1
- Chemical Name:
- 4-Phenylamino-6,7-dimethoxyquinazoline
- Synonyms
- WHI-P258;WHI-P258, 10 mM in DMSO;JAK3 INHIBITOR, NEGATIVE CONTROL;4-Phenylamino-6,7-dimethoxyquinazoline;6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE;6,7-dimethoxy-N-phenylquinazolin-4-amine;4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-PHENYLAMINE;JAK3 INHIBITOR NEGATIVE CONTROL;WHIP258;WHI P258;WHI P258,WHI-P258,inhibit,Inhibitor,JNK,WHI-P-258,WHIP258
- CBNumber:
- CB3348071
- Molecular Formula:
- C16H15N3O2
- Molecular Weight:
- 281.31
- MDL Number:
- MFCD01815294
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 441.2±40.0 °C(Predicted) |
|---|---|
| Density | 1+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml |
| form | A crystalline solid |
| pka | 6.19±0.70(Predicted) |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
4-Phenylamino-6,7-dimethoxyquinazoline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23453 | WHI-P258 ≥98% | 21561-09-1 | 5mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 23453 | WHI-P258 ≥98% | 21561-09-1 | 10mg | $130 | 2026-04-30 | Buy |
| Cayman Chemical | 23453 | WHI-P258 ≥98% | 21561-09-1 | 25mg | $223 | 2026-04-30 | Buy |
| Cayman Chemical | 23453 | WHI-P258 ≥98% | 21561-09-1 | 10 mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 23453 | WHI-P258 ≥98% | 21561-09-1 | 25 mg | $202 | 2024-03-01 | Buy |
4-Phenylamino-6,7-dimethoxyquinazoline Chemical Properties,Uses,Production
Description
WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 μM. However, it is inactive at JAK3 (IC50 = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.
Uses
4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).
References
[1] E A SUDBECK. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.[J]. Clinical Cancer Research, 1999, 5 6: 1569-1582.
[2] SHIN-ICHI YOKOTA . Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication[J]. Virology, 2005, 338 1: Pages 173-181. DOI: 10.1016/j.virol.2005.04.028
[3] H. TIBBLES. Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation*[J]. The Journal of Biological Chemistry, 2001, 25 1: 17815-17822. DOI: 10.1074/jbc.m011405200
4-Phenylamino-6,7-dimethoxyquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 470 | 55 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
