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4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:WHI-P258
CAS:21561-09-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: BOC Sciences
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Products Intro: Product Name:WHI-P258
CAS:21561-09-1
Package:25 mg Remarks:Reach out to us for more information about custom solutions.
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Products Intro: Product Name:WHI-P258
CAS:21561-09-1
Purity:99.59% Package:10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:WHI-P258
CAS:21561-09-1
Purity:0.99, AD68 Package:1g;1USD
Company Name: Zhejiang J&C Biological Technology Co.,Limited
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Products Intro: Product Name:WHI-P258
CAS:21561-09-1
Purity:99% Package:5KG;1KG Remarks:WHI-P258
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Basic information
Product Name:4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE
Synonyms:WHI-P258;JAK3 INHIBITOR NEGATIVE CONTROL;WHIP258;WHI P258;4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-PHENYLAMINE;6,7-dimethoxy-N-phenylquinazolin-4-amine;JAK3 INHIBITOR, NEGATIVE CONTROL;4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE;6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE
CAS:21561-09-1
MF:C16H15N3O2
MW:281.31
EINECS:
Product Categories:Inhibitors
Mol File:Mol File
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Structure
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Chemical Properties
Boiling point 441.2±40.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml
form A crystalline solid
pka6.19±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Usage And Synthesis
DescriptionWHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 μM. However, it is inactive at JAK3 (IC50 = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.
Uses4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).
References[1] E A SUDBECK. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.[J]. Clinical Cancer Research, 1999, 5 6: 1569-1582.
[2] SHIN-ICHI YOKOTA . Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication[J]. Virology, 2005, 338 1: Pages 173-181. DOI: 10.1016/j.virol.2005.04.028
[3] H. TIBBLES. Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation*[J]. The Journal of Biological Chemistry, 2001, 25 1: 17815-17822. DOI: 10.1074/jbc.m011405200
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Preparation Products And Raw materials
Tag:4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE(21561-09-1) Related Product Information
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