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| | 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Basic information |
| Product Name: | 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE | | Synonyms: | JAK3 INHIBITOR NEGATIVE CONTROL;WHIP258;WHI P258;4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-PHENYLAMINE;6,7-dimethoxy-N-phenylquinazolin-4-amine;JAK3 INHIBITOR, NEGATIVE CONTROL;4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE;6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE;WHI P258,WHI-P258,inhibit,Inhibitor,JNK,WHI-P-258,WHIP258 | | CAS: | 21561-09-1 | | MF: | C16H15N3O2 | | MW: | 281.31 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | Mol File |  |
| | 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Chemical Properties |
| Boiling point | 441.2±40.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml | | form | A crystalline solid | | pka | 6.19±0.70(Predicted) | | color | White to off-white |
| | 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Usage And Synthesis |
| Description | WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated Ki value of 72 μM. However, it is inactive at JAK3 (IC50 = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication. | | Uses | 4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3). | | References | [1] E A SUDBECK. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.[J]. Clinical Cancer Research, 1999, 5 6: 1569-1582.
[2] SHIN-ICHI YOKOTA . Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication[J]. Virology, 2005, 338 1: Pages 173-181. DOI: 10.1016/j.virol.2005.04.028
[3] H. TIBBLES. Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation*[J]. The Journal of Biological Chemistry, 2001, 25 1: 17815-17822. DOI: 10.1074/jbc.m011405200 |
| | 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Preparation Products And Raw materials |
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