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Antalarmin hydrochloride

Antalarmin hydrochloride Structure
Antalarmin hydrochloride structure
CAS No.
220953-69-5
Chemical Name:
Antalarmin hydrochloride
Synonyms
Antalarmin hydrochlo;Antalarmin hydrochloride;N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride;N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1)
CBNumber:
CB3352845
Molecular Formula:
C24H35ClN4
Molecular Weight:
415.02
MDL Number:
MFCD05664721
MOL File:
220953-69-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:00
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Antalarmin hydrochloride Properties

storage temp. 2-8°C
solubility DMSO: ~24 mg/mL, soluble
form solid
color off-white
InChI InChI=1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChIKey CGDGXEDXEXACKQ-UHFFFAOYSA-N
SMILES CC1=C(C2C(=NC(C)=NC=2N1C1C(=CC(C)=CC=1C)C)N(CC)CCCC)C.Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
Storage Class 11 - Combustible Solids

Antalarmin hydrochloride price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8727 Antalarmin hydrochloride ≥98% (HPLC), solid 220953-69-5 10mg $313 2026-04-30 Buy
Sigma-Aldrich A8727 Antalarmin hydrochloride ≥98% (HPLC), solid 220953-69-5 50mg $1020 2026-04-30 Buy
Cayman Chemical 15147 Antalarmin (hydrochloride) ≥98% 220953-69-5 5mg $121 2026-04-30 Buy
Cayman Chemical 15147 Antalarmin (hydrochloride) ≥98% 220953-69-5 10mg $169 2026-04-30 Buy
Cayman Chemical 15147 Antalarmin (hydrochloride) ≥98% 220953-69-5 25mg $359 2026-04-30 Buy
Product number Packaging Price Buy
A8727 10mg $313 Buy
A8727 50mg $1020 Buy
15147 5mg $121 Buy
15147 10mg $169 Buy
15147 25mg $359 Buy

Antalarmin hydrochloride Chemical Properties,Uses,Production

Description

Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (Ki = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.

Uses

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

storage

Desiccate at +4°C

References

[1] E L WEBSTER. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.[J]. Endocrinology, 1996, 137 12: 5747-5750. DOI: 10.1210/endo.137.12.8940412
[2] T DEAK. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.[J]. Endocrinology, 1999, 140 1: 79-86. DOI: 10.1210/endo.140.1.6415
[3] HESHAM FAHMY. The “homeostasis hormone” and its CRF receptor. From structure to function.[J]. Hormones-International Journal of Endocrinology and Metabolism, 2012, 11 3: 254-271. DOI: 10.14310/horm.2002.1355

Antalarmin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Antalarmin hydrochloride Suppliers

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
Nantong Hi-Future Biotechnology Co., Ltd +86-0513; 18051384581 sales@chemhifuture.com China 3074 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2971 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai Han-Xiang Chemical Co., Ltd. 17754423994 candy@biochempartner.com China 3057 58
Supplier Advantage
Nantong Hi-Future Biotechnology Co., Ltd 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Sigma-Aldrich 80
Shanghai Lollane Biological Technology Co.,Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Han-Xiang Chemical Co., Ltd. 58

View Lastest Price from Antalarmin hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Antalarmin hydrochloride pictures 2026-08-07 Antalarmin hydrochloride
220953-69-5
 $48.00-153.00 99.63% 10g TargetMol Chemicals Inc.
ANTALARMIN HYDROCHLORIDE pictures 2026-07-27 ANTALARMIN HYDROCHLORIDE
220953-69-5
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

Antalarmin hydrochloride Spectrum

ANTALARMIN HYDROCHLORIDE(220953-69-5)1HNMR

220953-69-5(Antalarmin hydrochloride)Related Search:

JNJ-19567470 4-Piperidineacetic acid, 1-[7-(4-broMo-2,6-diMethylphenyl)-2,5,6-triMethyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl]- 4-(N-ETHYL-N-4-HYDROXYBUTYL)AMINO-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)PYRROLO[2,3-D]PYRIMIDINE HYDROCHLORIDE ANTALARMIN HYDROCHLORIDE 4-Piperidineacetonitrile, 1-[7-(4-broMo-2,6-diMethylphenyl)-2,5,6-triMethyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl]-
CP 154526

1of2

N-BUTYL-N-ETHYL-2,5,6-TRIMETHYL-7-(2,4,6-TRIMETHYLPHENYL)-7H-PYRROLOL[2,3-D]PYRIMIDIN-4-AMINE HYDROCHLORIDE N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-,hydrochloride Antalarmin hydrochlo 7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-, hydrochloride (1:1) N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride Antalarmin hydrochloride 220953-69-5 C24H34N4HCl