CP 154526
- CAS No.
- 157286-86-7
- Chemical Name:
- CP 154526
- Synonyms
- CP154;CP-154;CP 154;CP-154,526;N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-;N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride
- CBNumber:
- CB5675292
- Molecular Formula:
- C23H32N4
- Molecular Weight:
- 364.53
- MDL Number:
- MFCD00930935
- MOL File:
- 157286-86-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 423.5±45.0 °C(Predicted) |
|---|---|
| Density | 1.06 |
| storage temp. | Desiccate at +4°C |
| pka | 6.97±0.30(Predicted) |
| FDA UNII | 9A549FB00R |
CP 154526 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2779 | CP154526 ≥99%(HPLC) | 157286-86-7 | 10 | $216 | 2021-12-16 | Buy |
| Tocris | 2779 | CP154526 ≥99%(HPLC) | 157286-86-7 | 50 | $893 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000117 | CP-154,526 95.00% | 157286-86-7 | 10MG | $724.41 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000117 | CP-154,526 95.00% | 157286-86-7 | 50MG | $1269.09 | 2021-12-16 | Buy |
CP 154526 Chemical Properties, Uses, Production
Uses
A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
Biological Activity
Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.
in vivo
CP 154526 (1-10 mg/kg; i.p.; once) exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2].
| Animal Model: | Male Sprague Dawley rats[2] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | i.p.; once |
| Result: | Exhibited signs of anxiolytic-like activity. |
CP 154526 Preparation Products And Raw materials
Raw materials
Preparation Products
CP 154526 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Latest Price from CP 154526 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | CP 154,526
157286-86-7
|
$1820.00-3100.00 | 10g | TargetMol Chemicals Inc. |
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- CP 154,526
157286-86-7
- $1820.00-3100.00
- TargetMol Chemicals Inc.
