Methyl 4-oxotetrahydrothiophene-3-carboxylate
- CAS No.
- 2689-68-1
- Chemical Name:
- Methyl 4-oxotetrahydrothiophene-3-carboxylate
- Synonyms
- AKOS 92615;methyl tetrahydro-4-oxo-3-thenoate;4-CARBOMETHOXYTETRAHYDRO-3-THIOPHENE;4-CARBOMETHOXYTETRAHYDRO-3-THIOPHENONE;3-Carbomethoxytetrahydrothiophene-4-one;METHYL 3-OXOTETRAHYDROTHIOPHENE4-CARBOXYLATE;METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE;Methyl-4-Oxo-Tetrahydro Thiphene-3-Carboxylate;Methyl 4-oxotetrahydrothiophene-3-carboxylate ,97%;Methyl 4-oxotetrahydrothiophene-3-carboxylate, 95+%
- CBNumber:
- CB3354748
- Molecular Formula:
- C6H8O3S
- Molecular Weight:
- 160.19
- MDL Number:
- MFCD00052381
- MOL File:
- 2689-68-1.mol
- MSDS File:
- SDS
| Melting point | 37-38 °C |
|---|---|
| Boiling point | 95 °C |
| Density | 1.309±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Chloroform |
| form | Solid |
| pka | 10.52±0.20(Predicted) |
| color | Light Yellow |
| InChI | InChI=1S/C6H8O3S/c1-9-6(8)4-2-10-3-5(4)7/h4H,2-3H2,1H3 |
| InChIKey | LEAKUJFYXNILRB-UHFFFAOYSA-N |
| SMILES | C1SCC(=O)C1C(OC)=O |
| EPA Substance Registry System | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester (2689-68-1) |
Methyl 4-oxotetrahydrothiophene-3-carboxylate price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 289843 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester Asreported | 2689-68-1 | 5g | $814 | 2026-06-03 | Buy |
| Usbiological | 289843 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester Asreported | 2689-68-1 | 10g | $1238 | 2026-06-03 | Buy |
| Usbiological | 289843 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester Asreported | 2689-68-1 | 25g | $2159 | 2026-06-03 | Buy |
| Usbiological | 289843 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester Asreported | 2689-68-1 | 50g | $3292 | 2026-06-03 | Buy |
| Usbiological | 289843 | 3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester Asreported | 2689-68-1 | 100g | $3787 | 2026-06-03 | Buy |
Methyl 4-oxotetrahydrothiophene-3-carboxylate Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
Methyl 4-oxotetrahydrothiophene-3-carboxylate is used in the preparation of a new class of neuroleptic agents.
Synthesis
2,3,4,5-Tetrahydro-4-oxo-3-thiophene carboxylic acid, methyl ester (L75a): 25.3 g (1.1 mol) of sodium were implemented in 190 mL abs. methanol to methylate. To methylate solution 70 g (0.360 mol) (L74) was added dropwise at the boiling point and the reaction mixture was heated for 45 min under reflux. The cooling mixture was poured onto a mixture of 500 mL ice and 300 mL water, acidified with 100 mL conc. HCl and the oily precipitating product was brought to crystallize under cooling with ice/sodium chloride bath. The crystals were sucked off, resumed in 100 mL methylene chloride and dried over sodium sulfate and evaporated. There were obtained 16.7 g of pale beige crystals. The aqueous phase was extracted three times with 100 mL of methylene chloride, the organic phase dried over sodium sulfate and evaporated. 30 g of crystalline product Methyl 4-oxotetrahydrothiophene-3-carboxylate was obtained. Yield: 46.7 g of light beige crystals (81 % of theory). mp 29-31 degC. TLC: Bz:MeOH:AcOH = 45:8:4, Rf = 0.75.
References
[1] Patent: US2016/204348, 2016, A1. Location in patent: Paragraph 0084; 0089
[2] Patent: WO2010/29577, 2010, A2. Location in patent: Page/Page column 41
[3] Patent: US2010/68178, 2010, A1. Location in patent: Page/Page column 17
[4] Patent: WO2006/102191, 2006, A1. Location in patent: Page/Page column 56; 87-88
[5] Journal of the American Chemical Society, 1946, vol. 68, p. 2229,2233
Methyl 4-oxotetrahydrothiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Youfu Pharmaceutical Technology Co., Ltd. | +86-0536-8226195 +86-13953676784 | lee@unipharm-sd.com | China | 493 | 58 |
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 4981 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Tianjin Yao Technology Development Co., Ltd. | 022-18902014291 18902014291 | byswxsb01@163.com | China | 98 | 58 |
View Latest Price from Methyl 4-oxotetrahydrothiophene-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
2689-68-1
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | Methyl 4-oxotetrahydrothiophene-3-carboxylate
2689-68-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-12-23 | METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
2689-68-1
|
$1.00 | 1KG | 85.0-99.8% | 20ton | Career Henan Chemical Co |
-
- METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
2689-68-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 4-oxotetrahydrothiophene-3-carboxylate
2689-68-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- METHYL 4-OXOTETRAHYDROTHIOPHENE-3-CARBOXYLATE
2689-68-1
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
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