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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester structure

CAS No.: 3392-12-9

Chemical Name:: tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

Synonyms: BOC-VAL-OSU;2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate;BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER;(S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate;￥545,287.00;Boc-Val-ONSu;BOC-VALINE-OSU;Boc-L-Val-ONSu;Boc-Val-succinimide;Boc-Val-OSu >=98.5% (N)

CBNumber:: CB3363294

Molecular Formula:: C14H22N2O6

Molecular Weight:: 314.33

MDL Number:: MFCD00037906

MOL File:: 3392-12-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:30:48

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tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Properties

Melting point	126-128 °C
Density	1.22±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	Powder
pka	10.72±0.46(Predicted)
color	White to off-white
optical activity	[α]20/D 38±1°, c = 2% in dioxane
Sensitive	Moisture Sensitive
BRN	1551859
Major Application	peptide synthesis
InChI	1S/C14H22N2O6/c1-8(2)11(15-13(20)21-14(3,4)5)12(19)22-16-9(17)6-7-10(16)18/h8,11H,6-7H2,1-5H3,(H,15,20)/t11-/m0/s1
InChIKey	POBDBYGSGKMZPH-NSHDSACASA-N
SMILES	CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)ON1C(=O)CCC1=O
CAS DataBase Reference	3392-12-9(CAS DataBase Reference)
FDA UNII	YZF2E7GBG6
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

WGK Germany

3-10-21

HS Code

2933998090

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15531	Boc-Val-OSu ≥98.5% (N)	3392-12-9	5g	$115	2026-04-30	Buy
Usbiological	264806	Boc-L-valine N-hydroxysuccinimide ester Asreported	3392-12-9	25g	$366	2026-06-03	Buy
Usbiological	264806	Boc-L-valine N-hydroxysuccinimide ester Asreported	3392-12-9	50g	$556	2026-06-03	Buy
Usbiological	264806	Boc-L-valine N-hydroxysuccinimide ester Asreported	3392-12-9	100g	$771	2026-06-03	Buy
Usbiological	264806	Boc-L-valine N-hydroxysuccinimide ester Asreported	3392-12-9	250g	$1068	2026-06-03	Buy

Product number	Packaging	Price	Buy
15531	5g	$115	Buy
264806	25g	$366	Buy
264806	50g	$556	Buy
264806	100g	$771	Buy
264806	250g	$1068	Buy

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

6066-82-6

13734-41-3

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester

3392-12-9

Step A: Boc-L-valine (1.03 g, 4.74 mmol), N-hydroxysuccinimide (1.22 g, 10.6 mmol), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 1.60 g, 8.35 mmol) were sequentially added to a dry round-bottom flask. The above reagents were dissolved in anhydrous dichloromethane (30 mL), and the reaction system was sealed through a rubber septum and displaced three times with argon to exclude oxygen. Subsequently, the reaction mixture was stirred at room temperature.After 3 days, thin layer chromatography (TLC) detection (ninhydrin color development) confirmed that the Boc-L-valine was fully reacted. The reaction solution was washed sequentially with water, saturated aqueous sodium bicarbonate, and the aqueous phase was back-extracted with dichloromethane. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and dried under vacuum to obtain white solid Boc-L-valine hydroxysuccinimide ester (1.52 g, 100% yield). The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 4.98 (broad peak, 1H), 4.58 (double peak, 1H), 2.82 (multiple peaks, 4H), 2.27 (multiple peaks, 1H), 1.44 (single peak, 9H), 1.03 (double peaks, 6H).

References

[1] Patent: WO2016/160615, 2016, A1. Location in patent: Paragraph 0444; 0445
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 14, p. 2461 - 2480
[3] Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2852 - 2857
[4] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984, p. 2305 - 2308
[5] Journal of Organic Chemistry, 1986, vol. 51, # 24, p. 4580 - 4585

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide N-Boc-L-valine n-(3-dimethylaminopropyl)-n'-ethylcarbodiimide hydrochloride Dichloromethane

Preparation Products

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Suppliers

Global Suppliers ( 143)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Beijing Ouhe Technology Co., Ltd	60
Jia Xing Isenchem Co.,Ltd	66
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
China DongFan Chemical Co.,LTD	66
Shandong Xiya Chemical Co., Ltd	57

View Latest Price from tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-07-20	tert-Butoxycarbonyl-L-valine 3392-12-9	$1.00	1Kg	98%	20T	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9	$1.00	1KG	99%	20kg	Career Henan Chemical Co
2019-07-06	tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester 3392-12-9	$7.00	1KG	99%	100KG	Career Henan Chemical Co

tert-Butoxycarbonyl-L-valine
3392-12-9
$1.00
98%
Shaanxi Dideu Medichem Co. Ltd

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
3392-12-9
$1.00
99%
Career Henan Chemical Co

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester
3392-12-9
$7.00
99%
Career Henan Chemical Co

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester Spectrum

tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester(3392-12-9)¹HNMR

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1of4

BOC-L-VALINE HYDROXYSUCCINIMIDE ESTER BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER BOC-VALINE-OSU N-ALPHA-T-BOC-L-VALINE N-HYDROXYSUCCINIMIDE ESTER N-BOC-L-VAL-N-HYDROXYSUCCINIMIDE N-TERT-BUTOXYCARBONYL-L-VALINE-N-HYDROXYSUCCINIMIDE ESTER tert-butyl (S)-[1-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]-2-methylpropyl]carbamate BOC-L-VALINE HYDROXYSUCCINIMIDESTER N-(tert-butoxycarbonyl)-L-valine hydroxysuccinimide ester tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester [(S)-1-[[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester Boc-L-Val-ONSu N-(tert-Butoxycarbonyl)-L-valine succinimidyl ester (S)-2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)-3-methylbutanoate L-Valine, N-[(1,1-diMethylethoxy)carbonyl]-, 2,5-dioxo-1-pyrrolidinyl ester Boc-Val-OSu >=98.5% (N) ￥545,287.00 Boc-Val-ONSu Boc-Val-succinimide Boc-L-valineN-hydroxysuccinimide ester≥ 99% (HPLC) N-Boc-L-valine N-succinimidyl ester (Tert-Butoxy)Carbonyl Val-Osu (2,5-Dioxopyrrolidin-1-yl) (2S)-2-(tert-butoxycarbonylamino)-3-methyl-butanoate (2,5-dioxopyrrolidin-1-yl)(2S)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate tert-Butoxycarbonyl-L-valine N-hydroxysuccinimide ester USP/EP/BP tert-Butoxycarbonyl-L-valine 2,5-Dioxopyrrolidin-1-yl (tert-butoxycarbonyl)-L-valinate BOC-VAL-OSU 3392-12-9 545-28-7 545287 C14H22N2O6 Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Valine Amino Acid Derivatives Amino Acid