Maleimide
- CAS No.
- 541-59-3
- Chemical Name:
- Maleimide
- Synonyms
- 1h-pyrrole-2,5-dione;PYRROLE-2,5-DIONE;Maleinimide;Maleic imide;MALEIC ACID IMIDE;MaleiMide, 98% 10GR;NSC 13684;MALEIMIDE;maleicimide;Maleimide>
- CBNumber:
- CB6358686
- Molecular Formula:
- C4H3NO2
- Molecular Weight:
- 97.07
- MDL Number:
- MFCD00005494
- MOL File:
- 541-59-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 91-93 °C (lit.) |
|---|---|
| Boiling point | 97-103°C 5mm |
| Density | 1,2493 g/cm3 |
| refractive index | 1.4543 (estimate) |
| Flash point | 97-103°C/5mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | Fine Crystalline Powder |
| pka | 8.52±0.20(Predicted) |
| color | White to slightly yellow |
| Water Solubility | SOLUBLE |
| λmax | 280nm(EtOH)(lit.) |
| BRN | 106910 |
| InChI | 1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7) |
| InChIKey | PEEHTFAAVSWFBL-UHFFFAOYSA-N |
| SMILES | O=C1NC(=O)C=C1 |
| CAS DataBase Reference | 541-59-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2519R1UGP8 |
| NIST Chemistry Reference | 1H-pyrrole-2,5-dione(541-59-3) |
| EPA Substance Registry System | 1H-Pyrrole-2,5-dione (541-59-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H314-H317 | |||||||||
| Precautionary statements | P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,C | |||||||||
| Risk Statements | 25-34-43-36/37/38-36 | |||||||||
| Safety Statements | 26-36/37/39-45-37/39-28A-7/9 | |||||||||
| RIDADR | UN 2923 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ON4800000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29251995 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 2 Oral Eye Dam. 1 Skin Corr. 1B Skin Sens. 1 |
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| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Maleimide price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 129585 | Maleimide 99% | 541-59-3 | 2g | $33.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 129585 | Maleimide 99% | 541-59-3 | 10g | $97.8 | 2026-04-30 | Buy |
| TCI Chemical | M0018 | Maleimide >98.0%(T) | 541-59-3 | 5g | $54 | 2026-04-30 | Buy |
| TCI Chemical | M0018 | Maleimide >98.0%(T) | 541-59-3 | 25g | $190 | 2026-04-30 | Buy |
| Usbiological | 281640 | Maleimide ≥95% | 541-59-3 | 25g | $460 | 2026-06-03 | Buy |
Maleimide Chemical Properties,Uses,Production
Chemical Properties
slight yellow crystalline powder
Uses
Rhodium-catalyzed conjugate arylation with arylboronic acids.1
Uses
Reacts quantitatively with sulfhydryl groups.Maleimide is used to immobilize the bovine serum albumin-boronic acid conjugates in association with silica beads. Its nanoparticle surface favors the conjugation with cell penetration peptides. It is involved in Rhodium-catalyzed conjugate arylation with arylboronic acids. It is actively involved in Michael additions and Diels-Alder reactions by the addition across the double bond. It acts as crosslinking reagents in polymer chemistry.
Definition
ChEBI: A cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure.
General Description
Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.
Hazard
A poison.
Safety Profile
Poison by intraperitoneal and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Purify it by sublimation in a vacuum. The UV has max at 216 and 280nm in EtOH. [de Wolf & van de Straete Bull Soc Chim Belg 44 288 1935, UV: Rondestvedt et al. J Am Chem Soc 78 6115 1956, IR: Chiorboli & Mirone Ann Chim (Rome) 42 681 1952, Beilstein 21/10 V 3.]
Maleimide Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Ruifengyuan Chemical Co., Ltd. | 15069072278 | qd-ruifengyuan@qq.com | China | 184 | 58 |
| Shanghai RC Chemicals Co., Ltd. | 21-58661250 18217085189; | 3059772675@qq.com | China | 131 | 64 |
| SHANDONG XINGRUNDA CHEMICAL CO.,LTD | 0534-18615348689 18615348689 | hclt1978@163.com | China | 35 | 58 |
| Jinan Ruisi Pharmaceutical Technology Co., LTD | 0531-0531-69900633 19963472814 | changyuan20@163.com | China | 9937 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1459 | 58 |
| Beijing Leaderherb Bio-Tech. Co., LTD. | 51288246 13366708252 | 300abc@sina.com | China | 91 | 58 |
| Qingdao Gelisi Pharmaceutical Co. , Ltd | 189-4623-7973 13375559818 | cfy69@163.com | China | 131 | 58 |
| Qingdao Rongrong Chemical Technology Co., Ltd | 15224422002 | 2467602940@qq.com | China | 33 | 58 |
| Jinan New Coordinates Technology Development Co., Ltd, | 0531-88870058 13188878598 | wks_ok@163.com | China | 12 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
