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ChemicalBook >> CAS DataBase List >>Caulophylline

Caulophylline

Caulophylline Structure
Caulophylline structure
CAS No.
486-86-2
Chemical Name:
Caulophylline
Synonyms
N-METHYLCYTISINE;Methylcytisine;(1r)-l;Caulophyllin;Caulophylline;12-Methylcytisine;12-methyl-cytisin;N-Methylcytisine-RM;Cytisine, 12-methyl-;(-)-N-Methylcytisine
CBNumber:
CB3366194
Molecular Formula:
C12H16N2O
Molecular Weight:
204.27
MDL Number:
MFCD00211091
MOL File:
486-86-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Caulophylline Properties

Melting point 137-139oC
alpha 30D -224° (c = 1.05 in water)
Boiling point 342.77°C (rough estimate)
Density 1.0565 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form powder
pka 9.61±0.20(Predicted)
color White to Off-White
InChI InChI=1S/C12H16N2O/c1-13-6-9-5-10(8-13)11-3-2-4-12(15)14(11)7-9/h2-4,9-10H,5-8H2,1H3/t9-,10+/m0/s1
InChIKey CULUKMPMGVXCEI-VHSXEESVSA-N
SMILES N12C(=O)C=CC=C1[C@]1([H])C[C@]([H])(C2)CN(C)C1
EWG's Food Scores 1
FDA UNII TT0MW69NCI
NIST Chemistry Reference Caulophylline(486-86-2)
UNSPSC Code 12352205
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P271-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  HA4400000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Toxicity LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)
NFPA 704
0
1 0

Caulophylline price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB00353 N-Methylcytisine ≥98% (HPLC) 486-86-2 5mg $216 2026-04-30 Buy
Sigma-Aldrich PHL83219 N-Methylcytisine phyproof? Reference Substance 486-86-2 10mg $543 2026-04-30 Buy
Sigma-Aldrich CDS010442 N-Methylcytisine AldrichCPR 486-86-2 25mg $308 2023-06-20 Buy
Cayman Chemical 34752 N-Methylcytisine ≥95% 486-86-2 10mg $81 2026-04-30 Buy
Cayman Chemical 34752 N-Methylcytisine ≥95% 486-86-2 25mg $181 2026-04-30 Buy
Product number Packaging Price Buy
SMB00353 5mg $216 Buy
PHL83219 10mg $543 Buy
CDS010442 25mg $308 Buy
34752 10mg $81 Buy
34752 25mg $181 Buy

Caulophylline Chemical Properties, Uses, Production

Description

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]20D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemical Properties

Colourless Needles

Uses

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

General Description

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

Biochem/physiol Actions

N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.

References

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

Caulophylline Preparation Products And Raw materials

Raw materials

Preparation Products

Caulophylline Suppliers

Global Suppliers ( 244)
Supplier Tel Email Country ProdList Advantage
ChengDu Yijierui Biotechnology CO., Ltd 18224018291 18224018291 yirui307@163.com China 996 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Shenzhen Sungening Bio-Tech Co., Ltd +86-0755-89668383 sales@sungening.com China 1319 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Supplier Advantage
ChengDu Yijierui Biotechnology CO., Ltd 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Sichuan Kulinan Technology Co., Ltd 57
Shenzhen Sungening Bio-Tech Co., Ltd 65
Dalian Meilun Biotech Co., Ltd. 58
BioBioPha Co., Ltd. 65

View Latest Price from Caulophylline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Methylcytisine pictures 2026-08-08 N-Methylcytisine
486-86-2
 $30.00-88.00 99.89% 10g TargetMol Chemicals Inc.
N-Methylcytisine pictures 2023-02-24 N-Methylcytisine
486-86-2
 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
Caulophylline pictures 2019-07-06 Caulophylline
486-86-2
 $1.00 1g 99% 100KG Career Henan Chemical Co
  • N-Methylcytisine pictures
  • N-Methylcytisine
    486-86-2
  • $0.00
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.

Caulophylline Spectrum

Caulophylline(486-86-2)1HNMR

486-86-2 (Caulophylline) Related Search:

N,N-Dimethylformamide (-)-SPARTEINE 1-Methylpyrrolidine 2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI) N-Methyl-2-pyrrolidone
Sodium carboxymethyl cellulose 1-Methylimidazole CYTISINE ANAGYRINE (-)-N-Methylephedrine
(-)-2-[Methylamino]-1-phenylpropane Caulophylline hydriodide L-N-Methylephedrine hydrochloride Caulophylline 3-(2-Amino-4-methylsulfanyl-butyryl)-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one
3-(2-Amino-3-methyl-butyryl)-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one 3-(2-Amino-acetyl)-1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one AKOS 213-126

1of4

(1r)-l 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)- 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)- 12-methyl-cytisin 12-Methylcytisine Caulophyllin Caulophylline Cytisine, 12-methyl- (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one [1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one METHYLCYTISINE, N-(P) N-Methylcytisine AldrichCPR N-Methylcytisine hydrobromide N-Methylcytisine, 98%, from Sophora flavescens Aiton 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)- Caulophylline USP/EP/BP (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]... (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one Caulophylline (N-Methylcytisine) N-Methylcytisine-RM N-Methylcytisine, 10 mM in DMSO N-Methylcytisine (-)-N-Methylcytisine Methylcytisine N-METHYLCYTISINE 486-86-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). Miscellaneous Reagents standardized herbal extract