2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
- CAS No.
- 209256-42-8
- Chemical Name:
- 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
- Synonyms
- Tasimelteon INT;Tasimelteon intermediate;2,3-DIHYDRO-BENZOFURAN-4-CARBALDEHYDE;2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE;2,3-dihydro-1-benzofuran-4-carbaldehyde;4-Benzofurancarboxaldehyde, 2,3-dihydro-;4-Benzofurancarboxaldehyde, 2,3-dihydro- (9CI)
- CBNumber:
- CB3368204
- Molecular Formula:
- C9H8O2
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD03426203
- MOL File:
- 209256-42-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D446965 | 2,3-Dihydrobenzofuran-4-carbaldehyde | 209256-42-8 | 250mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 0701AB | 2,3-Dihydrobenzofuran-4-carbaldehyde | 209256-42-8 | 250mg | $143 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139110 | 2,3-Dihydro-4-benzofurancarboxaldehyde | 209256-42-8 | 500mg | $150 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD139110 | 2,3-Dihydro-4-benzofurancarboxaldehyde | 209256-42-8 | 250mg | $100 | 2021-12-16 | Buy |
| AK Scientific | 0701AB | 2,3-Dihydrobenzofuran-4-carbaldehyde | 209256-42-8 | 100mg | $126 | 2021-12-16 | Buy |
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Chemical Properties,Uses,Production
Uses
2,3-Dihydrobenzofuran-4-carbaldehyde is used in the synthesis of macroline derivatives as inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B.
Synthesis
209256-41-7
209256-42-8
The general procedure for the synthesis of 2,3-dihydrobenzofuran-4-carbaldehyde from 4-hydroxymethyl-benzodihydrofuran was as follows: a dichloromethane solution (40 mL, 2 M) of oxalyl chloride was stirred at -78 °C and DMSO (8.10 mL, 114 mmol) was slowly added. Subsequently, a dichloromethane solution (35 mL) of 4-hydroxymethyl-benzodihydrofuran (8.53 g, 56.9 mmol) was added dropwise and stirring was continued for 30 min at -78 °C. Upon completion of the reaction, triethylamine (33 mL, 228 mmol) was carefully added to quench the reaction. The resulting suspension was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). The organic layer was washed three times with water and twice with brine sequentially, and finally concentrated by vacuum to give 2,3-dihydrobenzofuran-4-carbaldehyde as an oil (8.42 g, 100%), which could be used for subsequent reactions without further purification.
References
[1] Patent: EP1041980, 2005, B1. Location in patent: Page 17
[2] Patent: EP1027043, 2004, B1. Location in patent: Page/Page column 17
2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 281 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
View Lastest Price from 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | Tasimelteon INT
209256-42-8
|
US $0.00 / KG | 25KG | 95% | Inquiry | PNP Biotech Co. Ltd | |
 |
2020-01-03 | 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
209256-42-8
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- Tasimelteon INT
209256-42-8
- US $0.00 / KG
- 95%
- PNP Biotech Co. Ltd
-
- 2,3-DIHYDRO-4-BENZOFURANCARBOXALDEHYDE
209256-42-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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