4-vinyl-2，3-dihydrobenzofurane
- CAS No.
- 230642-84-9
- Chemical Name:
- 4-vinyl-2，3-dihydrobenzofurane
- Synonyms
- 4-Vinyl-2,3-dihydrobenzofuran;4-ethenyl-2,3-dihydro-1-benzofuran;4-Vinyl-2,4-dihydrobenzofuran;4-ethenyl-2,3-dihydrobenzofuran;4-Vinyl-2,3-dihydrobenzofuran(VBF);Benzofuran, 4-ethenyl-2,3-dihydro-;4-Ethenyl-2,3-dihydrobenzofuran,98% (stabilized with TBC);Imtermediate tasimelteon(4-ethenyl-2,3-dihydrobenzofuran)
- CBNumber:
- CB51235183
- Molecular Formula:
- C10H10O
- Molecular Weight:
- 146.19
- MDL Number:
- MFCD09030659
- MOL File:
- 230642-84-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2932990090 |
4-vinyl-2，3-dihydrobenzofurane price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA002M04 | 4-Vinyl-2,3-dihydrobenzofuran 97%(stabilizedwithTBC) | 230642-84-9 | 250mg | $18 | 2026-05-28 | Buy |
| aablocks | AA002M04 | 4-Vinyl-2,3-dihydrobenzofuran 97%(stabilizedwithTBC) | 230642-84-9 | 1g | $68 | 2026-05-28 | Buy |
| aablocks | AA002M04 | 4-Vinyl-2,3-dihydrobenzofuran 97%(stabilizedwithTBC) | 230642-84-9 | 5g | $238 | 2026-05-28 | Buy |
| aablocks | AA002M04 | 4-Vinyl-2,3-dihydrobenzofuran 98% | 230642-84-9 | 25g | $1074 | 2026-05-28 | Buy |
| ACHEMBLOCK | S76553 | 4-ethenyl-2,3-dihydro-1-benzofuran 97% | 230642-84-9 | 1G | $100 | 2026-05-27 | Buy |
4-vinyl-2，3-dihydrobenzofurane Chemical Properties, Uses, Production
Uses
4-Vinyl-2,3-dihydrobenzofuran is an intermediate in the synthesis of tasimelteon (T007740). Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.
Synthesis
230642-83-8
230642-84-9
General procedure for the synthesis of 4-vinyl-2,3-dihydrobenzofuran from the compound (CAS: 230642-83-8): dissolve toluene sulfonate of part C (100 g, 314 mmol) in THF (1200 mL) in a 2000 mL three-necked round-bottomed flask equipped with a mechanical stirrer, a digital thermometer, and a homogeneous-pressure charging funnel. Room temperature was maintained. The reaction mixture was cooled to 0 °C via an ice water bath. A THF solution of t-BuOK (1 M, 345.5 mL) was slowly added dropwise at 0 °C for 110 min. The reaction mixture was gradually warmed to ambient temperature and stirring was continued for 2 hours. Upon completion of the reaction, water (350 mL) and EtOAc (600 mL) were added to separate the organic and aqueous layers. The aqueous layer was further extracted with EtOAc (2 x 150 mL). All EtOAc layers were combined, washed with brine (2 × 150 mL), dried over MgSO4 and filtered. The solvent was removed by distillation under reduced pressure to give 46 g of the target product 4-vinyl-2,3-dihydrobenzofuran in 100% yield.
References
[1] Patent: EP1041980, 2005, B1. Location in patent: Page/Page column 33
[2] Journal of Chemical Research, 2016, vol. 40, # 11, p. 667 - 669
[3] Patent: CN106542973, 2017, A. Location in patent: Paragraph 0098-0101
4-vinyl-2，3-dihydrobenzofurane Preparation Products And Raw materials
4-vinyl-2，3-dihydrobenzofurane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824; | bjkaida@163.com | China | 1597 | 59 |
| Beijing Huikang Boyuan Chemical Tech Co., Ltd | 010-68862197 13810598707;13810598707 | sales@huikangchem.com | China | 97 | 61 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. | 21-33585366 13311639313 | sales@shyrchem.com | China | 807 | 55 |
| China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 762 | 50 | |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| Shanghai eliv pharmaceutical Co.,Ltd. | 021-50158063 | sales@elivpharma.com | China | 480 | 58 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Taizhou Jinghao Chemical Co., Ltd. | 86-576-88550069 13486888296 | sales@jinghaochem.com | China | 37 | 55 |
View Latest Price from 4-vinyl-2，3-dihydrobenzofurane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | 4-VINYL-2,3-DIHYDROBENZOFURAN
230642-84-9
|
25KG | 95% HPLC 98% | PNP Biotech Co. Ltd | |||
 |
2019-12-23 | 4-vinyl-2，3-dihydrobenzofurane
230642-84-9
|
$1.00 | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- 4-VINYL-2,3-DIHYDROBENZOFURAN
230642-84-9
- $0.00
- 95% HPLC 98%
- PNP Biotech Co. Ltd
-
- 4-vinyl-2，3-dihydrobenzofurane
230642-84-9
- $1.00
- 99.99%
- Career Henan Chemical Co
