NUARIMOL
- CAS No.
- 63284-71-9
- Chemical Name:
- NUARIMOL
- Synonyms
- murox;el228;C11185;el2289;Trimiol;TRIMIDAL;NUARIMOL;triminol;guantlet;trimifruitsc
- CBNumber:
- CB3375554
- Molecular Formula:
- C17H12ClFN2O
- Molecular Weight:
- 314.74
- MDL Number:
- MFCD00078677
- MOL File:
- 63284-71-9.mol
- MSDS File:
- SDS
| Melting point | 126°C |
|---|---|
| Boiling point | 475.2±40.0 °C(Predicted) |
| Density | 1.3255 (estimate) |
| vapor pressure | 1 x 10-5 Pa at 23 °C |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 11.37±0.29(Predicted) |
| Water Solubility | 26 mg l-1 (pH 7) at 25 °C |
| color | White to Pale Yellow |
| BRN | 6223667 |
| Henry's Law Constant | 1.5×107 mol/(m3Pa) at 25℃, MacBean (2012) |
| Major Application |
agriculture environmental |
| InChI | InChI=1S/C17H12ClFN2O/c18-16-4-2-1-3-15(16)17(22,13-9-20-11-21-10-13)12-5-7-14(19)8-6-12/h1-11,22H |
| InChIKey | SAPGTCDSBGMXCD-UHFFFAOYSA-N |
| SMILES | C(O)(C1C=NC=NC=1)(C1C=CC(F)=CC=1)C1=CC=CC=C1Cl |
| FDA UNII | ZU7K80U0CY |
| Pesticides Freedom of Information Act (FOIA) | Nuarimol |
| EPA Substance Registry System | Nuarimol (63284-71-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | UV9279700 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
NUARIMOL price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CRM31116 | Nuarimol certified reference material, TraceCERT?, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland | 63284-71-9 | 50MG | $69.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 31116 | Nuarimol PESTANAL | 63284-71-9 | 100mg | $51 | 2025-07-31 | Buy |
| TRC | TRC-N925320-5MG | Nuarimol | 63284-71-9 | 5mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-N925320-25MG | Nuarimol | 63284-71-9 | 25mg | $212 | 2026-06-03 | Buy |
| TRC | TRC-N925320-10MG | Nuarimol | 63284-71-9 | 10mg | $144 | 2026-06-03 | Buy |
NUARIMOL Chemical Properties,Uses,Production
Uses
Nuarimol is a systemic fungicide with both curative and protective activity. It controls a wide range of pathogenic fungi, e.g. Cercosporella spp., Septoria spp., Ustilago spp., powdery mildews, leaf spot, etc. in cereals (as a foliar spray and as a seed treatment), powdery mildews on pome fruits, stone fruits, vines, cucurbits and other crops and scab on apples.
Uses
Nuarimol is used in the preparation of difluoroethyl-containing heterocyclic compounds useful as antiviral agents and fungicides. Also used as a substance in the modelling inhibition of avian aromatase by azole pesticides.
Production Methods
The production of nuarimol involves a multi-step organic synthesis beginning with the preparation of its key intermediate, 2'-chloro-4-fluoro-benzophenone, through a Friedel–Crafts acylation reaction. This step typically uses aluminum chloride as a catalyst to facilitate the condensation of chloro- and fluoro-substituted benzene rings with a suitable acyl donor. Once the benzophenone intermediate is formed, it undergoes further functionalisation, including the introduction of a triazole ring and a hydroxyl group, which are essential for nuarimol’s fungicidal activity.
Mechanism of action
Systemic with curative and protective action. Sterol demethylation (ergosterol biosynthesis) inhibitor.
Metabolic pathway
Photolytic degradation is the primary dissipation mechanism of nuarimol in the environment. Major degradation reactions observed on plants/soil surfaces and water include hydroxylation of the phenyl groups, oxidation of the carbinol carbon atom, dehalogenation and carbinol dehydroxylation (Scheme 1). The primary metabolic pathway of nuarimol in rats involves mainly aryl hydroxylation (Scheme 2).
Degradation
Nuarimol is stable to hydrolytic degradation when maintained in sterile
buffered solutions (pH 3,6 and 9) in the dark at 52 °C (Saunders, 1977). It
was readily degraded in distilled water via photolysis. The photolytic
DT50 of nuarimol was approximately 1 hour. Numerous photoproducts
were observed; however, no structural characterisation information was
reported (Zornes and Donoho, 1978).
Nuarimol was extensively photodegraded on solid surfaces. More than
80 photodegradation products were observed when nuarimol was
exposed to sunlight on a stainless steel surface for up to 150 hours (Althaus, 1980a). All photoproducts were formed at very low levels (less
than 3% each). The structures of 23 photoproducts were identified. An
abbreviated photodegradation pathway of nuarimol (based on products
accounting for 1% or greater) is presented in Scheme 1. These products
were generated from the following reactions: aryl hydroxylation of the
chlorophenyl and fluorophenyl moieties (to yield 2, 3), cleavage of the
pyrimidine ring and the oxidation of the carbinol carbon atom (4,5) and
dehydroxylation of the carbinol moiety (6). Carboxylic acid fragments
from the phenyl(7,8,9) and pyrimidine moieties (10), resulting from the
cleavage of the parent phenyl and pyrimidine linkages, were also
observed.
Pesticide Type
Fungicide
NUARIMOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| Changzhou Extraordinary Pharmatech co., LTD. | 0519-82111935 15195055733 | info@feifanchem.com | China | 737 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Huainan Kedi Chemical Factory | 0554-2106669 | sales1@kedichem.com | China | 4914 | 55 |
| TianJin Alta Scientific Co., Ltd. | 022-65378550-8551 | contact@altascientific.com | China | 2772 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
